Results 31 to 40 of about 28,974 (217)

Purinergic P2 and glutamate NMDA receptor coupling contributes to osmotically driven excitability in hypothalamic magnocellular neurosecretory neurons

Journal of Physiology, 2021
Purinergic and glutamatergic signalling pathways play a key role in regulating the activity of hypothalamic magnocellular neurosecretory neurons (MNNs).
H. Ferreira-Neto, V. Antunes, J. Stern
semanticscholar   +1 more source

The role of TRPC6 calcium channels and P2 purinergic receptors in podocyte mechanical and metabolic sensing.

Physiology International, 2021
Podocyte calcium (Ca2+) signaling plays important roles in the (patho)physiology of the glomerular filtration barrier. Overactivation of podocyte transient receptor potential canonical (TRPC) channels including TRPC6 and purinergic signaling via P2 ...
Georgina Gyarmati, Ildikó Toma, Audrey Izuhara, James L. Burford, U. Shroff, Stella Papadouri, Sachin K. Deepak, J. Peti-Peterdi   +7 more
semanticscholar   +1 more source

The adenosinergic machinery in cancer: In-tandem insights from basic mechanisms to therapy

Frontiers in Immunology, 2023
Extracellular adenosine (eADO) signaling has emerged as an increasingly important regulator of immune responses, including tumor immunity. eADO is mainly produced from extracellular ATP (eATP) hydrolysis.
Chifei Kang, Chifei Kang, Luyu Liu, Chengyu Wu, Lingyun Li, Xiao Jia, Wendi Xie, Siyu Chen, Xinying Wu, Huaxiao Zheng, Jingxin Liu, Rongsong Li, Bin Zeng   +12 more
doaj   +1 more source

The Role of Purinergic Signaling in Heart Transplantation

Frontiers in Immunology, 2022
Heart transplantation remains the optimal treatment option for patients with end-stage heart disease. Growing evidence demonstrates that purinergic signals mediated by purine nucleotides and nucleosides play vital roles in heart transplantation ...
Yanzhi Jiang, Jianxin Lin, Haiyun Zheng, Ping Zhu   +3 more
doaj   +1 more source

Extracellular ATP Mediates Cancer Cell Migration and Invasion Through Increased Expression of Cyclooxygenase 2

Frontiers in Pharmacology, 2021
The tumor microenvironment plays a major role in the ability of the tumor cells to undergo metastasis. A major player of tumors gaining metastatic property is the inflammatory protein, cyclooxygenase 2 (COX-2).
Shilpa Sharma, Harshit Kalra, Ravi Shankar Akundi   +2 more
doaj   +1 more source

P2X Receptors: Potential Therapeutic Targets for Symptoms Associated With Lung Cancer — A Mini Review

Frontiers in Oncology, 2021
Symptoms associated with lung cancer mainly consist of cancer-associated pain, cough, fatigue, and dyspnea. However, underlying mechanisms of lung cancer symptom clusters remain unclear.
Yonglin Mai, Zhihua Guo, Weiqiang Yin, Nanshan Zhong, Peter V. Dicpinigaitis, Ruchong Chen   +5 more
doaj   +1 more source

Traditional Chinese medicine alleviating neuropathic pain targeting purinergic receptor P2 in purinergic signaling: A review

Brain Research Bulletin, 2023
Past studies have suggested that Chinese herbal may alleviate neuropathic pain, and the mechanism might target the inhibition of purinergic receptor P2.
Bo Yang, Nengwei Yu
doaj  

Hemolysis in human erythrocytes by Clostridium perfringens epsilon toxin requires activation of P2 receptors

Virulence, 2018
Epsilon-toxin (ETX) is produced by types B and D strains of Clostridium perfringens, which cause fatal enterotoxaemia in sheep, goats and cattle. Previous studies showed that only a restricted number of cell lines are sensitive to ETX and ETX-induced ...
Jie Gao, Wenwen Xin, Jing Huang, Bin Ji, Shan Gao, Liang Chen, Lin Kang, Hao Yang, Xin Shen, Baohua Zhao, Jinglin Wang   +10 more
doaj   +1 more source

Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease

Frontiers in Neuroscience, 2021
Huntington’s disease (HD) is a devastating, progressive, and fatal neurodegenerative disorder inherited in an autosomal dominant manner. This condition is characterized by motor dysfunction (chorea in the early stage, followed by bradykinesia, dystonia ...
Melissa Talita Wiprich, Melissa Talita Wiprich, Carla Denise Bonan, Carla Denise Bonan, Carla Denise Bonan   +4 more
doaj   +1 more source

Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium.

AJP - Renal Physiology, 2013
In addition to its role as a physical barrier, the urothelium is considered to play an active role in mechanosensation. A key mechanism is the release of transient mediators that activate purinergic P2 receptors and transient receptor potential (TRP ...
Saqib Shabir, W. Cross, Lisa A. Kirkwood, Joanna F. Pearson, Peter A. Appleby, D. Walker, I. Eardley, J. Southgate   +7 more
semanticscholar   +1 more source