Results 101 to 110 of about 577,314 (185)
P2X2/3 and P2X3 receptors contribute to the metaboreceptor component of the exercise pressor reflex
, 2010 The exercise pressor reflex is due to activation of thin fiber afferents within contracting muscle. These afferents are in part stimulated by ATP activation of purinergic 2X (P2X) receptors during contraction.
Jennifer L. McCord +2 more
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Molecular Pain, 2019 Electroacupuncture has been shown to effectively reduce chronic pain in patients with nerve injury. The underlying mechanisms are not well understood. Accumulated evidence suggests that purinergic P2X3 receptors (P2X3Rs) in dorsal root ganglion neurons ...
Yi Liang +5 more
doaj +1 more source
Purinergic receptors activating rapid intracellular Ca 2+ increases in microglia [PDF]
, 2006 We provide both molecular and pharmacological evidence that the metabotropic, purinergic, P2Y6, P2Y12 and P2Y13 receptors and the ionotropic P2X4 receptor contribute strongly to the rapid calcium response caused by ATP and its analogues in mouse ...
Hughen, Ronald W. +3 more
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P2X3 receptors and peripheral pain mechanisms
, 2004 ATP released from damaged or inflamed tissues can act at P2X receptors expressed on primary afferent neurones. The resulting depolarization can initiate action potentials that are interpreted centrally as pain.
R. Alan North, North, R. Alan
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Neural regeneration research, 2013 Electroacupuncture at Shangjuxu (ST37) and Tianshu (ST25) can improve visceral hypersensitivity in rats. Colorectal distension was used to establish a rat model of chronic visceral hypersensitivity. Immunohistochemistry was used to detect P2X2 and P2X3 receptor expression in dorsal root ganglia from rats with chronic visceral hypersensitivity.
Weng, Zhijun +6 more
openaire +2 more sources
Role of P2Y receptors in trigeminal pain signalling
, 2008 Migraine is a chronic neurovascular disorder associated to activation and sensitization of the trigeminovascular system. Since little information is available on purinergic transmission in the generation of migraine pain, we aimed at studying the ...
M. Fumagalli +4 more
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Scientific ReportsPlant extracts have been useful for oral health or dentistry. However, only a few evidence-based justifications exist. This study evaluated Multidentia crassa (Hiern) Bridson & Verdc, one of the oral health-used plants in Malawi.
Ibrahim Chikowe +3 more
doaj +1 more source
P2X3 receptors and sensory transduction
, 2008 It has been known for many years that exogenously administered adenosine 5 -triphosphate (ATP) evokes acute pain, but the physiological and pathophysiological roles of endogenous ATP in nociceptive signalling are only now becoming clear. ATP produces its
Kennedy, Charles
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, 2020 Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics. Pain is the most unbearable symptom accompanying primary bone cancers and bone metastases.
Turhanen P. +8 more
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Selective Calcium-Dependent Inhibition of ATP-Gated P2X3 Receptors by Bisphosphonate-Induced Endogenous ATP Analog ApppI [PDF]
, 2017 Copyright © 2017 by The American Society for Pharmacology and Experimental Therapeutics. Pain is the most unbearable symptom accompanying primary bone cancers and bone metastases.
Turhanen P. +8 more
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