Results 81 to 90 of about 577,314 (185)

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

Taste‐Active Peptides: Sensation Mechanisms and Structure–Taste Relationships

Sensory Neuroscience, Volume 2, Issue 3, September 2026.
Overview of taste‐active peptides, including taste bud cellular organization, peptide–receptor interactions and signaling pathways, structure–taste relationships, and integrated computational and experimental strategies for peptide discovery, mechanism elucidation, and flavor modulation.
Dengyi Pei, Jucai Xu, Weizu Yu, Quanyou Guo, Wenmeng He   +4 more
wiley   +1 more source

Electroacupuncture alleviates neuropathic pain in a rat model of CCD via suppressing P2X3 expression in dorsal root ganglia

Chinese Medicine
Background Sciatica and low back pain are prevalent clinical types of neuropathic pain that significantly impair patients' quality of life. Conventional therapies often lack effectiveness, making these conditions challenging to treat. Electroacupuncture (
Yu Zheng, Minjian Jiang, Zhouyuan Wei, Hengyu Chi, Yurong Kang, Siyi Li, Yinmu Zheng, Xiaofen He, Xiaomei Shao, Jianqiao Fang, Yongliang Jiang   +10 more
doaj   +1 more source

P2X₃ Knock-Out Mice Reveal a Major Sensory Role for Urothelially Released ATP [PDF]

, 2001
The present study explores the possible involvement of a purinergic mechanism in mechanosensory transduction in the bladder using P2X₃ receptor knock-out (P2X₃ ⁻⁄⁻) and wild-type control (P2X₃ ⁺⁄⁺) mice.
Bodin, P, Cockayne, DA, Kasakov, L, Burnstock, G, Rong, W, Bardini, M, Ford, APDW, Vlaskovska, M   +7 more
core  

Endogenous Purinergic Control of Bladder Activity via Presynaptic P2X₃and P2X_2/3Receptors in the Spinal Cord [PDF]

The Journal of Neuroscience, 2010
P2X3and P2X2/3receptors are localized on sensory afferents both peripherally and centrally and have been implicated in various sensory functions. However, the physiological role of these receptors expressed presynaptically in the spinal cord in regulating sensory transmission remains to be elucidated.
Kaan, Timothy K. Y., Yip, Ping K., Grist, John, Cefalu, Joseph S., Nunn, Philip A., Ford, Anthony P. D. W., Zhong, Yu, McMahon, Stephen B.   +7 more
openaire   +3 more sources

What Role Does the Central Nervous System Play in Refractory LUTS, and What Are the Therapeutic Implications? ICI‐RS 2025

Neurourology and Urodynamics, Volume 45, Issue 5, Page 929-936, June 2026.
ABSTRACT Aims While many patients with lower urinary tract symptoms (LUTS) improve by treating peripheral causes, a substantial proportion continue to experience symptoms despite apparently successful interventions. Central nervous system (CNS) mechanisms could potentially contribute to persisting symptoms after the initial peripheral cause has been ...
Mathijs M. de Rijk, Michel Wyndaele, Ana Charrua, Christopher Fry, Paul Abrams, Gommert A. van Koeveringe, Anthony J. Kanai, Marcus J. Drake   +7 more
wiley   +1 more source

Purinergic signalling: Sensitisation of recombinant P2X receptors [PDF]

, 1999
ATP acts as a fast neurotransmitter for a family of ligand-gated ion channels (P2X receptors) in the central and peripheral nervous systems. The potential for H+, Zn2+ and diadenosine polyphosphates to modify purinergic signalling was investigated on ATP-
Wildman, Scott Shaw
core   +1 more source

Post-translational regulation of P2X receptor channels: modulation by phospholipids

Frontiers in Cellular Neuroscience, 2013
P2X receptor channels mediate fast excitatory signaling by ATP and play major roles in sensory transduction, neuro-immune communication and inflammatory response.
Louis-Philippe eBernier, Ariel eAse, Philippe eSeguela   +2 more
doaj   +1 more source

Optochemical modulation of corneal cold nerve terminal impulse activity with a photochromic ion channel blocker

British Journal of Pharmacology, Volume 183, Issue 3, Page 545-559, February 2026.
Background and Purpose The functional organization of corneal cold nerve endings, critical structures in maintaining the ocular surface, remains poorly understood. Here, the photoisomerizable small‐molecule diethylamine‐azobenzene‐quaternary ammonium (DENAQ) was used to photomodulate activity of cold‐sensing nerve terminals in control and chronic tear ...
David Ares‐Suárez, Almudena Iñigo‐Portugués, Enrique Velasco, Susana Quirce, Fernando Aleixandre‐Carrera, Ariadna Díaz‐Tahoces, M. Carmen Acosta, Wan‐Chen Lin, Richard H. Kramer, Carlos Belmonte, Juana Gallar, Victor Meseguer   +11 more
wiley   +1 more source

Generalised Hodgkin–Huxley model captures human P2X and AMPA receptor currents

The Journal of Physiology, Volume 604, Issue 1, Page 214-246, 1 January 2026.
Abstract figure legend A universal, biophysically interpretable mathematical model for human ionotropic receptors. The generalised Hodgkin–Huxley (gHH) model unifies the mathematical description of all major ligand‐gated ionotropic receptors (P2X1–7, AMPA) across diverse cell types, capturing activation, inactivation, desensitisation and recovery ...
Alireza Poshtkohi, Brian D. Gulbransen
wiley   +1 more source