Results 71 to 80 of about 577,314 (185)

P2X3 receptor antagonism improves hindlimb blood flow during exercise in a conscious ovine model of hypertensive heart failure with preserved ejection fraction

The Journal of Physiology, EarlyView.
Abstract figure legend A preclinical large‐animal model of hypertensive heart failure with preserved ejection fraction (HFpEF) was used to examine the role of purinergic P2X3 receptor signalling during treadmill exercise. Animals were instrumented with either thoracic cardiac output and coronary flow probes or abdominal renal and hindlimb blood flow ...
Mridula Pachen, Siyi Chen, Joshua W.‐H. Chang, Audrys Pauza, Julia Shanks, Bindu George, Julian Paton, Rohit Ramchandra   +7 more
wiley   +1 more source

Non-peptidergic primary afferents are presynaptic to neurokinin-1 receptor immunoreactive lamina I projection neurons in rat spinal cord

Molecular Pain, 2012
Background Pain-related (nociceptive) information is carried from the periphery to the dorsal horn of the spinal cord mostly by two populations of small diameter primary afferents, the peptidergic and the non-peptidergic.
Saeed Abeer W, Ribeiro-da-Silva Alfredo
doaj   +1 more source

Neuropharmacology of purinergic receptors in human submucous plexus: Involvement of P2X1, P2X2, P2X3 channels, P2Y and A3 metabotropic receptors in neurotransmission [PDF]

Neuropharmacology, 2015
The role of purinergic signaling in human ENS is not well understood. We sought to further characterize the neuropharmacology of purinergic receptors in human ENS and test the hypothesis that endogenous purines are critical regulators of neurotransmission.LSCM-Fluo-4/(Ca(2+))-imaging of postsynaptic Ca(2+) transients (PSCaTs) was used as a reporter of ...
A, Liñán-Rico, J E, Wunderlich, J T, Enneking, D R, Tso, I, Grants, K C, Williams, A, Otey, K, Michel, M, Schemann, B, Needleman, A, Harzman, F L, Christofi   +11 more
openaire   +2 more sources

Pregabalin Efficacy in Treatment of Chronic Neurogenic Cough

The Laryngoscope, Volume 136, Issue 11, Page 4938-4944, November 2026.
The use of neuromodulators for chronic cough has increased; however, the choice of medication, dosing regimen, and duration are still unclear. This longitudinal study of 95 adults taking pregabalin, 75 mg twice daily, for CNC demonstrated 78% improvement or resolution of cough, 17% unchanged, 1% worse cough, with a mean of 6 weeks of therapy, and only ...
Jacqui Allen, Carmen Esna, Camille Prigent, Anna Miles   +3 more
wiley   +1 more source

Purinergic receptors in skeletal muscles in health and in muscular dystrophy [PDF]

, 2014
The P2 purinergic (nucleotide) receptor super-family comprises of two families of protein. The P2X, which are channel-forming ionotropic receptors and the P2Y metabotropic receptors activating G protein-mediated signalling pathways.
Young, Christopher, Zablocki, Krzysztof, Rog, Justyna, Young, Christopher N. J., Rog, J., Gorecki, Dariusz, Zablocki, K., Krasowska, Elzbieta, Sinadinos, Anthony, Gorecki, Darek, Krasowska, E.   +10 more
core  

Purinergic and muscarinic modulation of the cell cycle and calcium signaling in the chick retinal ventricular zone [PDF]

, 2002
Spontaneous calcium transients occur in the ventricular zone of the chick retina and result from the endogenous release of neurotransmitters in the absence of action potentials.
Catsicas, M., Peter Mobbs, Pearson, R., Pearson, Rachel; id_orcid, Becker, D., Pearson, R, Rachel Pearson, Becker, D, Mobbs, P, Becker, David, Marina Catsicas, Catsicas, Marina, Catsicas, M, Mobbs, Peter, David Becker, Mobbs, P.   +15 more
core   +1 more source

Neuropathic Pain: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Neuropathic pain arises from peripheral nerve injury, central sensitization, neurotransmitter imbalance, neuroimmune activation, and maladaptive circuit remodeling. Clinical phenotyping and multimodal imaging can identify dominant peripheral and central mechanisms.
Yaling Dai, Mengquan Tan, Man Yuan, Huixian Zhou, Qin Xie, Jiling Zeng, Yixin Yang, Xinran He, Siyuan Song   +8 more
wiley   +1 more source

Calcium/calmodulin-dependent serine protein kinase (CASK) is a new intracellular modulator of P2X3 receptors

, 2013
ATP-gated P2X3 receptors of sensory ganglion neurons are important transducers of painful stimuli and are modulated by extracellular algogenic substances, via changes in the receptor phosphorylation state.
Gnanasekaran, A, Hullugundi, S, Birsa, N, Hseuh, Y. P, Bianchini, G, Fabbretti, E., Nistri, Andrea, Sundukova, M   +7 more
core   +1 more source

Postnatal developmental changes in the laryngeal chemosensory cell clusters of rats

Journal of Anatomy, Volume 249, Issue 4, Page 769-786, October 2026.
Chemosensory cell clusters appeared in the rat larynx 2 days after birth and were already connected to afferent nerve fibers. Their number increased until 3 weeks of age, then stabilized while continuing to grow through the addition of new cells. Because their number reached a plateau around the time of weaning, their development may be linked to ...
Sayed Sharif Abdali, Kanna Miyazaki, Takuya Yokoyama, Nobuaki Nakamuta, Tomoyuki Saino, Yoshio Yamamoto   +5 more
wiley   +1 more source

Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies* [PDF]

, 2016
Purinergic homomeric P2X3 and heteromeric P2X2/3 receptors are ligand-gated cation channels activated by ATP. Both receptors are predominantly expressed in nociceptive sensory neurons, and an increase in extracellular ATP concentration under pathological
Hasa-Moreno, Adela, Strop, Pavel, Zhu, Guoyun, Stroud, Robert, Shelton, David, Melton Witt, Jody, Rajpal, Arvind, Shcherbatko, Anatoly, Pios, Ariel, Yu, Jessica, Loo, Carole, Poulsen, Kris, Brown, Colleen, Lee, John K, Krimm, Stellanie, Foletti, Davide   +15 more
core   +1 more source