Results 51 to 60 of about 577,314 (185)

Exacerbated ATP transmission in the carotid body is linked to glomus cell expansion in spontaneously hypertensive rats. [PDF]

J Physiol
Abstract figure legend Exacerbated ATP signalling in the carotid body (CB) of spontaneously hypertensive rats (SHRs) arises from expansion of the chemosensory glomus cell compartment and reduced extracellular ATP metabolism, leading to increased purinergic drive.
Felippe ISA, Pauza A, Gold OMS, Shen X, Brognara F, Nonu RR, Pen DK, Bose A, Bardsley EN, Ponnampalam AP, Moraes DJA, Paton JFR.   +11 more
europepmc   +2 more sources

Mechanosensory Signaling in Enterochromaffin Cells and 5-HT Release: Potential Implications for Gut Inflammation

Frontiers in Neuroscience, 2016
Enterochromaffin cells (EC) synthesize 95% of the body 5-HT and release 5-HT in response to mechanical or chemical stimulation. EC cell 5-HT has physiological effects on gut motility, secretion and visceral sensation.
Andromeda Linan Rico, Andromeda Linan Rico, Fernando Ochoa-Cortes, Arthur Beyder, Suren Soghomonyan, Alix Zuleta-Alarcon, Vincenzo Coppola, Fievos Leontiou Christofi   +7 more
doaj   +1 more source

Promoted Interaction of Nuclear Factor-κB With Demethylated Purinergic P2X3 Receptor Gene Contributes to Neuropathic Pain in Rats With Diabetes [PDF]

Diabetes, 2015
Painful diabetic neuropathy is a common complication of diabetes produced by mechanisms that as yet are incompletely defined. The aim of this study was to investigate the roles of nuclear factor-κB (NF-κB) in the regulation of purinergic receptor P2X ligand-gated ion channel 3 (P2X3R) plasticity in dorsal root ganglion (DRG) neurons of rats with ...
Hong-Hong, Zhang, Ji, Hu, You-Lang, Zhou, Xin, Qin, Zhen-Yuan, Song, Pan-Pan, Yang, Shufen, Hu, Xinghong, Jiang, Guang-Yin, Xu   +8 more
openaire   +2 more sources

P2X3 receptors contribute to transition from acute to chronic muscle pain

, 2020
This study aimed to evaluate whether the development and/or maintenance of chronic-latent muscle hyperalgesia is modulated by P2X3 receptors. We also evaluate the expression of P2X3 receptors and PKCε of dorsal root ganglions during these processes.
Jorge, Carolina Ocanha, Rodrigues, Hayla Lourenço, Luchessi, Augusto Ducati [UNESP], de Azambuja, Graciana, de Oliveira-Fusaro, Maria Cláudia Gonçalves, Gomes, Beatriz Botasso, Augusto Ducati Luchessi, Luchessi, Augusto Ducati, Graciana de Azambuja, Maria Cláudia Gonçalves de Oliveira-Fusaro, Hayla Lourenço Rodrigues, Carolina Ocanha Jorge, Beatriz Botasso Gomes   +12 more
core   +1 more source

Peripheral targets for neuropathic pain

British Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour, Cosmin I. Ciotu, Felix J. Resch, Michael J. M. Fischer   +3 more
wiley   +1 more source

Purinergic signalling: past, present and future [PDF]

, 2009
The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
G. Burnstock, Burnstock, G
core  

Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex [PDF]

, 2014
Communication between neuronal and glial cells is important for many brain functions. Astrocytes can modulate synaptic strength via Ca2+-stimulated release of various gliotransmitters, including glutamate and ATP. A physiological role of ATP release from
Lalo, Ulyana, Pankratov, Yuriy, Palygin, Oleg, Oleg Palygin (407627), Philip G Haydon, Ulyana Lalo (506296), Yuriy Pankratov, Seyed Rasooli-Nejad (506297), Rasooli-Nejad, Seyed, Yuriy Pankratov (407630), Oleg Palygin, Ulyana Lalo, Haydon, Philip G., Jemma Andrew, Jemma Andrew (506298), Philip G. Haydon (506299), Andrew, Jemma, Seyed Rasooli-Nejad, Pankratov Yuriy, Lalo Ulyana, Andrew Jemma, Palygin Oleg, Rasooli-Nejad Seyed, Haydon Philip G.   +23 more
core   +2 more sources

P2X3 purinergic receptor overexpression is associated with poor recurrence-free survival in hepatocellular carcinoma patients

Oncotarget, 2015
P2 purinergic receptors are overexpressed in certain cancer tissues, but the pathophysiologic relevance of purinergic signaling in hepatocellular carcinoma (HCC) remains unknown. To examine the role of P2 purinergic signaling in the pathogenesis of HCC and characterize extracellular nucleotide effects on HCC cell proliferation, two independent HCC ...
Janielle P, Maynard, Ju-Seog, Lee, Bo Hwa, Sohn, Xiaoying, Yu, Dolores, Lopez-Terrada, Milton J, Finegold, John A, Goss, Sundararajah, Thevananther   +7 more
openaire   +3 more sources

Purinergic receptor expression in neuronal, bladder smooth muscle and urothelial cells: characterization and inhibition by low molecular weight antagonists [PDF]

, 2009
P2 purinoceptors comprise ionotropic (P2X) and metabotropic (P2Y) receptor families, responsive to nucleotide ligands and diversely distributed on virtually every mammalian cell. Most cells and tissues co-express multiple subtypes of purinoceptor; thus,
Gever, J.L.
core  

Adipose stem-cell-derived microvesicles ameliorate long-term bladder ischemia-induced bladder underactivity

Journal of the Formosan Medical Association
Background/purpose: The mechanism for long-term hypoxia/ischemia induced bladder underactivity is uncertain. It requires an effectively therapeutic treatment.
Bing-Juin Chiang, Su-Han Mao, Tung-Sheng Chen, Shiu-Dong Chung, Chiang-Ting Chien   +4 more
doaj   +1 more source