Results 31 to 40 of about 577,314 (185)

Purinergic signaling in the gastrointestinal tract [PDF]

, 2011
Geoffrey Burnstock completed a BSc at King's College London and a PhD at University College London. He held postdoctoral fellowships with Wilhelm Feldberg (National Institute for Medical Research), Edith Bülbring (University of Oxford) and C.
Geoffrey Burnstock, Burnstock, G
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Double P2X2/P2X3 Purinergic Receptor Knockout Mice Do Not Taste NaCl or the Artificial Sweetener SC45647 [PDF]

Chemical Senses, 2009
The P2X ionotropic purinergic receptors, P2X2 and P2X3, are essential for transmission of taste information from taste buds to the gustatory nerves. Mice lacking both P2X2 and P2X3 purinergic receptors (P2X2/P2X3(Dbl-/-)) exhibit no taste-evoked activity in the chorda tympani and glossopharyngeal nerves when stimulated with taste stimuli from any of ...
Meghan C, Eddy, Benjamin K, Eschle, Jennell, Barrows, Robert M, Hallock, Thomas E, Finger, Eugene R, Delay   +5 more
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The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]

, 2013
Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Unwin, RJ, Eilidh eCraigie, Scott S Wildman, Wildman, Scott S.P., Eilidh Craigie, Rebecca E. Birch, Robert John Unwin, Craigie, Eilidh, Craigie, E, Rebecca E Birch, Unwin, Robert J., Unwin, Robert J, Birch, Rebecca E., Birch, RE, Robert J. Unwin, Wildman, SS, Scott S. Wildman, Birch, Rebecca E, Wildman, Scott   +18 more
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Immunocytochemical analysis of P2X2 in rat circumvallate taste buds

BMC Neuroscience, 2012
Background Our laboratory has shown that classical synapses and synaptic proteins are associated with Type III cells. Yet it is generally accepted that Type II cells transduce bitter, sweet and umami stimuli.
Yang Ruibiao, Montoya Alana, Bond Amanda, Walton Jenna, Kinnamon John C   +4 more
doaj   +1 more source

A2BR adenosine receptor modulates sweet taste in circumvallate taste buds. [PDF]

PLoS ONE, 2012
In response to taste stimulation, taste buds release ATP, which activates ionotropic ATP receptors (P2X2/P2X3) on taste nerves as well as metabotropic (P2Y) purinergic receptors on taste bud cells.
Shinji Kataoka, Arian Baquero, Dan Yang, Nicole Shultz, Aurelie Vandenbeuch, Katya Ravid, Sue C Kinnamon, Thomas E Finger   +7 more
doaj   +1 more source

Protective Effects of Hydrogen Sulfide Against the ATP-Induced Meningeal Nociception

Frontiers in Cellular Neuroscience, 2020
We previously showed that extracellular ATP and hydrogen sulfide (H2S), a recently discovered gasotransmitter, are both triggering the nociceptive firing in trigeminal nociceptors implicated in migraine pain.
Kseniia Koroleva, Kseniia Koroleva, Elizaveta Ermakova, Alsu Mustafina, Raisa Giniatullina, Rashid Giniatullin, Rashid Giniatullin, Guzel Sitdikova   +7 more
doaj   +1 more source

Treatment with the soluble guanylate cyclase activator BAY 60-2770 restores in vitro bladder contractile responses in a rat model of chronic prostatitis

Continence, 2022
Aim:: Examine how innate bladder contractility and corresponding receptor expression was affected by chronic prostatitis (CP) and how treatment with the soluble guanylate cyclase (sGC) activator BAY 60-2770 influenced this.
Ozgu Aydogdu, Fernando Perez, Jan Rataj, Felicia Nilsson, Patrik Aronsson, Thomas Carlsson, Peter Sandner, Bhavik Patel, Gunnar Tobin, Michael Winder   +9 more
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Pathogenesis evidence from human and animal models of detrusor underactivity

Tzu Chi Medical Journal, 2022
Detrusor underactivity (DU) is a common urodynamic diagnosis in patients with lower urinary tract symptoms and large post-voiding residual volume. Animal and human studies showed the possible etiologies of DU include central or peripheral nerve injury ...
Jia-Fong Jhang, Yuan-Hong Jiang, Yung-Hsiang Hsu, Han-Chen Ho, Hann-Chorng Kuo   +4 more
doaj   +1 more source

Purinergic P2X3 receptors in the carotid body as new therapeutic targets for controlling heart failure

Purinergic Signalling, 2023
Abstract Heart failure is associated with multiple mechanisms, including sympatho-excitation, and is one of the leading causes of death worldwide. Enhanced carotid body chemoreflex function is strongly related to excessive sympathetic nerve activity and sleep-disordered breathing in heart failure.
Ximeng He, Zhichao Zhou
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P2X receptors: Insights from the study of the domestic dog [PDF]

, 2023
Fifty years ago, the late Geoffrey Burnstock described the concept of purinergic nerves and transmission bringing into existence the broader concepts of purinergic signaling including P2X receptors.
Reece A. Sophocleous, Ronald Sluyter, Sophocleous, Reece A., Stokes, Leanne, Sluyter, Ronald, Leanne Stokes   +5 more
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