Results 11 to 20 of about 577,314 (185)

Mechanisms underlying purinergic P2X3 receptor-mediated mechanical allodynia induced in diabetic rats [PDF]

Molecular Pain, 2011
Background Diabetic neuropathy is a common neuropathy associated with paresthaesia and pain. The mechanisms underlying the painful conditions are not well understood.
Xu Guang-Yin, Li Guangwen, Liu Ningang, Huang Li-Yen   +3 more
doaj   +5 more sources

The Role of Purinergic P2X3 Receptors and Endometriosis-Associated Hyperalgesia [PDF]

Purinergic Signalling
Endometriosis is a chronic gynecological condition characterized by endometrial tissue outside the uterine cavity. Recent research has focused on the relationship between the purinergic system and endometriosis. As a purinergic system component, extracellular adenosine triphosphate (ATP) has been involved as a crucial mediator of chronic pain ...
Yghor Augusto da Rocha Ricardo, Débora Tavares de Resende E Silva, Letícia de Souza Matias   +2 more
exaly   +4 more sources

Prenatal exposure to valproic acid induces alterations in the expression and activity of purinergic receptors in the embryonic rat brain

Folia Neuropathologica, 2022
Purinergic signalling is involved in the control of several processes related to brain development, such as neurogenesis and gliogenesis, migration and differentiation of neuronal precursors, synaptogenesis and synaptic elimination to achieve a fully ...
Lidia Babiec, Anna Wilkaniec, Agata Adamczyk   +2 more
doaj   +2 more sources

2′,3′-O-Substituted ATP derivatives as potent antagonists of purinergic P2X3 receptors and potential analgesic agents [PDF]

Purinergic Signalling, 2016
Blocking membrane currents evoked by the activation of purinergic P2X3 receptors localized on nociceptive neurons represents a promising strategy for the development of agents useful for the treatment of chronic pain conditions. Among compounds endowed with such antagonistic action, 2',3'-O-(2,4,6-trinitrophenyl)-ATP (TNP-ATP) is an ATP analogue, whose
DAL BEN, Diego, MARCHENKOVA, Anna, BUCCIONI, Michela, LAMBERTUCCI, Catia, SPINACI, Andrea, MARUCCI, Gabriella, NISTRI, Andrea, VOLPINI, Rosaria   +7 more
openaire   +5 more sources

Development of a reliable test system for purinergic P2X3 receptors [PDF]

, 2016
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Student: Šárka Tomanová Supervisors: Prof. PharmDr. Martin Doležal, Ph.D., Prof. Dr. Christa Elisabeth Müller Title of diploma thesis: Development of a reliable test system for purinergic P2X3 receptors Purinergic P2X3 receptor is ...
Tomanová, Šárka
openaire   +2 more sources

P2X(1) and P2X(3) purinergic receptors differentially modulate the inflammatory response in human osteoarthritic synovial fibroblasts.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2010
P2X receptors are membrane ion channels activated by extracellular adenosine 5'-triphosphate (ATP) which contribute to various physiological processes. The present study describes in synovial fibroblasts (SFs) obtained from osteoarthritis (OA) patients and in SW 982 cells derived from human synovial sarcoma a pharmacological characterization of P2X(1 ...
VARANI, Katia, DE MATTEI, Monica, VINCENZI, Fabrizio, TOSI, ALICE, TARGA, Martina, Masieri FF, PELLATI, Agnese, MASSARI, Leo, BOREA, Pier Andrea   +8 more
openaire   +3 more sources

Presence of Cleaved Synaptosomal-Associated Protein-25 and Decrease of Purinergic Receptors P2X3 in the Bladder Urothelium Influence Efficacy of Botulinum Toxin Treatment for Overactive Bladder Syndrome. [PDF]

PLoS ONE, 2015
To evaluate whether botulinum toxin A (BoNT-A) injection and Lipotoxin (liposomes with 200 U of BoNT-A) instillation target different proteins, including P2X3, synaptic vesicle glycoprotein 2A, and SNAP-25, in the bladder mucosa, leading to different ...
Hsin-Tzu Liu, Sung-Ho Chen, Michael B Chancellor, Hann-Chorng Kuo   +3 more
doaj   +4 more sources

PHARMACOLOGICAL CHARACTERIZATION OF P2X1 AND P2X3 PURINERGIC RECEPTORS IN BOVINE CHONDROCYTES AND FIBROBLAST-LIKE SYNOVIOCYTES

, 2009
Extracellular nucleotides, acting through purinergic receptors, play a central role in the regulation of bone and cartilage metabolism. Chondrocytes within articular cartilage are responsible for the synthesis and degradation of the extracellular matrix, which in healthy tissue provide to mechanical functionality.
VARANI, Katia, VINCENZI, Fabrizio, TOSI, ALICE, GESSI, Stefania, MERIGHI, Stefania, PELLATI, Agnese, DE MATTEI, Monica, BOREA, Pier Andrea   +7 more
openaire   +2 more sources

ATP Release and Purinergic Signaling Potentiate β-Adrenergic Effects on Brown Adipocytes. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Brown adipose tissue (BAT) specializes in energy consumption and thermogenesis in response to cold stress. Brown adipocytes (BA) express purinergic receptors, yet little is known about the source of extracellular ATP and the role of purinergic signaling, and the potential interaction with β‐adrenergic signaling.
Tozzi M, Berggreen EB, Zhang R, Gudiksen A, Li W, Matz MB, Pilegaard H, Hansen JB, Novak I.   +8 more
europepmc   +2 more sources

Electrical Activity of the Bladder Is Attenuated by Intravesical Inhibition of P2X2/3 Receptors During Micturition in Female Rats [PDF]

International Neurourology Journal, 2017
Purpose To simultaneously monitor electrical discharges in various bladder regions and the external urethral sphincter (EUS) during voiding contractions, and to assess the functional role of myogenic modulation of the lower urinary tract (LUT) by ...
Betsy H. Salazar, Kristopher A. Hoffman, Chuan Zhang, Alex Kavanagh, Yingchun Zhang, Timothy B. Boone, Alvaro Munoz   +6 more
doaj   +1 more source