Pirt reduces bladder overactivity by inhibiting purinergic receptor P2X3 [PDF]
Nature Communications, 2015 Pirt is a transmembrane protein predominantly expressed in peripheral neurons. However, the physiological and pathological roles of Pirt in hollow viscus are largely unknown. Here we show that Pirt deficiency in mice causes bladder overactivity. The density of α,β-meATP-induced currents is significantly reinforced in Pirt-deficient dorsal root ganglion
Xiao-Fei, Gao +8 more
openaire +2 more sources
ATP enhances spontaneous calcium activity in cultured suburothelial myofibroblasts of the human bladder. [PDF]
PLoS ONE, 2011 BACKGROUND: Suburothelial myofibroblasts (sMF) are located underneath the urothelium in close proximity to afferent nerves. They express purinergic receptors and show calcium transients in response to ATP.
Sheng Cheng +5 more
doaj +1 more source
Physiological mechanisms and therapeutic targets in chronic cough. [PDF]
Physiol RepAbstract Cough is a vital defensive reflex that safeguards the airways; however, it can become maladaptive and pathological. Chronic cough (>8 weeks in duration) affects up to 10% of the global adult population and is associated with considerable health status impairment. The understanding of cough physiology remains limited.
Brown JC +3 more
europepmc +2 more sources
Journal of the Formosan Medical Association, 2021 Background/Purpose: To investigate the effects of simulated childbirth on the gene expression of parasympathetic muscarinic, purinergic (P2X), and neurokinin receptors of lower urinary tract in rats.
Cheng-Yu Long +5 more
doaj +1 more source
Voiding Dysfunction in Old Male Rats Associated With Enlarged Prostate and Irregular Afferent-Triggered Reflex Responses [PDF]
International Neurourology Journal, 2020 Purpose This study was conducted to evaluate the hypothesis that an enlarged prostate in old rats may lead to complications associated with voiding dysfunction involving ionotropic P2X2/3-type purinergic receptors Methods Intact animals were divided into
Chuan Zhang +5 more
doaj +1 more source
Prenatal expression of purinergic receptor P2X3 in human dorsal root ganglion [PDF]
Purinergic Signalling, 2011 The dorsal root ganglion (DRG) is consisted of neurons that relay multiple types of spinal sensory stimuli to the central nervous system. Several neuroactive molecules may be involved in sensory modulation especially pain processing at the DRG, including the purinergic receptor P2X3 and calcitonin-gene-related peptide (CGRP).
Aihua, Pan +7 more
openaire +2 more sources
Purinergic and Cholinergic Drugs Mediate Hyperventilation in Zebrafish: Evidence from a Novel Chemical Screen. [PDF]
PLoS ONE, 2016 A rapid test to identify drugs that affect autonomic responses to hypoxia holds therapeutic and ecologic value. The zebrafish (Danio rerio) is a convenient animal model for investigating peripheral O2 chemoreceptors and respiratory reflexes in ...
Saman Rahbar, Wen Pan, Michael G Jonz
doaj +1 more source
Correction to: The role of purinergic P2X3 receptors and endometriosis-associated hyperalgesia. [PDF]
Purinergic SignalPretto KP +7 more
europepmc +3 more sources
Deletion of P2X2 and P2X3 receptor subunits does not alter motility of the mouse colon
Frontiers in Neuroscience, 2010 Purinergic P2X receptors contribute to neurotransmission in the gut. P2X receptors are ligand-gated cation channels that mediate synaptic excitation in subsets of enteric neurons.
Matthew DeVries +3 more
doaj +1 more source
Dual Effect of Acid pH on Purinergic P2X3 Receptors Depends on the Histidine 206 Residue [PDF]
Journal of Biological Chemistry, 2007 Whole cell patch clamp investigations were carried out to clarify the pH sensitivity of native and recombinant P2X(3) receptors. In HEK293 cells permanently transfected with human (h) P2X(3) receptors (HEK293-hP2X(3) cells), an acidic pH shifted the concentration-response curve for alpha,beta-methylene ATP (alpha,beta-meATP) to the right and increased ...
Zoltan, Gerevich +7 more
openaire +2 more sources