Results 61 to 70 of about 577,314 (185)

Action of Natural Products on P2 Receptors: A Reinvented Era for Drug Discovery

Molecules, 2012
Natural products contribute significantly to available drug therapies and have been a rich source for scientific investigation. In general, due to their low cost and traditional use in some cultures, they are an object of growing interest as alternatives
Luiz Alves, Valber Frutuoso, Leonardo Ferreira, Rômulo Bezerra, Robson Faria   +4 more
doaj   +1 more source

Contributions of purinergic P2X3 receptors within the midbrain periaqueductal gray to diabetes-induced neuropathic pain

The Journal of Physiological Sciences, 2015
Hyperalgesia and allodynia are commonly observed in patients with diabetic neuropathy. The mechanisms responsible for neuropathic pain are not well understood. Thus, in this study, we examined the role played by purinergic P2X3 receptors of the midbrain periaqueductal gray (PAG) in modulating diabetes-induced neuropathic pain because this brain region ...
Jianfei, Guo, Xudong, Fu, Xia, Cui, Minhua, Fan   +3 more
openaire   +2 more sources

Nutrient‐specific combinatorial secretion of GLP‐1 and neurotransmitters in the enteroendocrine L‐cell line GLUTag

The FEBS Journal, EarlyView.
Enteroendocrine L cells function as chemosensors in the intestine. Using the L‐cell line GLUTag, we show that distinct nutrients trigger different combinations of co‐secretion of GLP‐1 and neurotransmitters: D‐glucose evokes GLP‐1, glutamate, and ATP; L‐glutamine evokes GLP‐1 and glutamate; sucralose and butyrate evoke only GLP‐1.
Yo Ito, Kazuki Harada, Yuri Osuga‐Yoshiike, Masami Yokota Hirai, Tetsuya Kitaguchi, Takashi Tsuboi   +5 more
wiley   +1 more source

Topical ATP Application in the Peripheral Swallowing-Related Regions Facilitates Triggering of the Swallowing Reflex Involving P2X3 Receptors

Function
The swallowing reflex is a critical component of the digestive process, triggered when food or liquids pass from the oral cavity to the oesophagus. Although adenosine triphosphate (ATP) is involved in various physiological processes, its potential to ...
Mohammad Zakir Hossain, Hiroshi Ando, Rita Rani Roy, Junichi Kitagawa   +3 more
doaj   +1 more source

Synergistic Effects of Bacterial Mimetic and Mechanical Stimulation in Dental Pulp Cell Inflammatory Signalling: A Laboratory Investigation

International Endodontic Journal, EarlyView.
ABSTRACT Objectives Mechanical and/or microbial stimuli can prompt extracellular ATP release in many cell types, where it acts as an inflammatory mediator to amplify pain signals and inflammation. This study aimed to investigate the synergistic effects of microbial and/or mechanical stimulation on ATP and cytokine release from dental pulp cells (DPCs ...
Orla M. Dunne, Lorcan P. McGarvey, Imad About, Fionnuala T. Lundy, Ikhlas El‐Karim   +4 more
wiley   +1 more source

262 MODULATION OF BLADDER AFFERENT SIGNALS IN NORMAL AND SPINAL CORD INJURED RATS BY P2X3 AND P2X2/3 PURINERGIC RECEPTORS [PDF]

Journal of Urology, 2012
plete spinal cord transection (spinal cord injured: SCI) at the T8/T9 level or a sham procedure (nonlesion: NL) were performed. Four weeks later, rats were again anesthetized with isofluorane, a suprapubic and a vein catheter were implanted and tracheotomy was performed for artificial ventilation. Laminectomy was executed at the L2 spinal level.
Alvaro Munoz, George Somogyi, Timothy Boone, Anthony Ford, Christopher Smith   +4 more
openaire   +1 more source

Anatomical and functional mapping of vagal nociceptive sensory nerve subsets innervating the mouse lower airways by intersectional genetics

The Journal of Physiology, EarlyView.
Abstract figure legend We used an intersectional approach with recombinase‐expressing mice and adeno‐associated virus to map and modulate distinct nociceptive afferents in the vagal ganglia. TRPV1+P2X2+ neurons resided in the nodose ganglion (N), innervated the lungs (many projected into the alveoli) but not the trachea, and projected to the nucleus ...
Mayur J. Patil, Justin Shane Hooper, Seol‐Hee Kim, Parmvir K. Bahia, Nika Pavelkova, Sanjay S. Nair, Teresa S. Darcey, Karina V. Lurye, Meghana Madaram, Jailene Fiallo, Stephen H. Hadley, Thomas E. Taylor‐Clark   +11 more
wiley   +1 more source

High‐altitude headache: Insights into pathophysiology and potential treatment implications

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude headache occurs during prolonged exposure to low oxygen, such as during ascent to high altitude. Several risk factors increase its likelihood, with the degree of hypoxia, often driven by rapid ascent to greater altitudes, being the most prominent factor.
Marika Falla, Florian Frank, Giacomo Strapazzon, Justin Lawley   +3 more
wiley   +1 more source

Activation of Adenosine Triphosphate-Gated Purinergic 2 Receptor Channels by Transient Receptor Potential Vanilloid Subtype 4 in Cough Hypersensitivity

Biomolecules
Background: Transient receptor potential vanilloid subtype 4 (TRPV4) is a Ca2+-permeable non-selective cation channel that is involved in the development of cough hypersensitivity. Purinergic 2 receptors (P2X) belong to a class of adenosine triphosphate (
Wanzhen Li, Shengyuan Wang, Tongyangzi Zhang, Yiqing Zhu, Li Yu, Xianghuai Xu   +5 more
doaj   +1 more source

A taste for ATP: neurotransmission in taste buds

Frontiers in Cellular Neuroscience, 2013
Not only is ATP a ubiquitous source of energy but it is also used widely as an intercellular signal. For example, keratinocytes release ATP in response to numerous external stimuli including pressure, heat and chemical insult. The released ATP activates
Thomas E. Finger, Sue C Kinnamon
doaj   +1 more source