Results 91 to 100 of about 577,314 (185)

Targeting ecto‐5′‐nucleotidase (CD73) and cAMP alleviates carotid body hyperactivity and reduces blood pressure in chronically hypoxic rats

The Journal of Physiology, Volume 604, Issue 1, Page 626-652, 1 January 2026.
Abstract figure legend CD73 promotes carotid body hyperactivity in chronically hypoxic animals. Exposure to chronic hypoxia (CH) (FiO2 of 12% for 10 days) increases the proportion of CD73+TH+ cells in the carotid body and induces basal chemoafferent hyperactivity.
Demitris Nathanael, Andrew M. Coney, Dhaifallah Alotaibi, Prem Kumar, Andrew P. Holmes   +4 more
wiley   +1 more source

A nociceptive-nociplastic spectrum of myofascial orofacial pain: insights from neuronal ion channel studies

Frontiers in Cellular Neuroscience
Myofascial orofacial pain, traditionally viewed as a nociceptive pain condition, also exhibits characteristics consistent with nociplastic pain—pain arising from altered nociception without clear evidence of tissue damage.
Nontawat Chuinsiri, Nontawat Chuinsiri, Watcharaphol Tiskratok, Watcharaphol Tiskratok, Teekayu Plangkoon Jorns   +4 more
doaj   +1 more source

Single onabotulinumtoxinA 200U dose improved clinical symptoms but not urothelial dysfunction in neurogenic detrusor overactivity due to spinal cord injury

Journal of the Formosan Medical Association, 2019
Objective: To evaluate the changes in urothelial dysfunction protein expressions in bladder after onabotulinumtoxin injection and correlate that with clinical outcomes in spinal cord injury (SCI) patients.
Sheng-Fu Chen, Yuan-Hong Jiang, Hann-Chorng Kuo   +2 more
doaj   +1 more source

A Narrative Review of Neuroimmune Mechanisms Linking Inflammation and Psychological Symptoms in IBS

Advanced Gut &Microbiome Research, Volume 2026, Issue 1, 2026.
Background Irritable bowel syndrome (IBS) is traditionally classified as a functional gastrointestinal disorder, yet it is frequently accompanied by anxiety and depressive symptoms that substantially worsen disease burden. Recent studies indicate that gastrointestinal and psychological manifestations of IBS arise from shared biological mechanisms ...
Vlada Stark, Autena Asefirad, Isabelle Kovaltchouk, Alexandrea Pitts, Amy E. L. Stone, Jiong Yu   +5 more
wiley   +1 more source

Relationship between the change of ATP level controlled by ectonucleotidases and endometriosis-associated infertility and pain

Gynecology and Obstetrics Clinical Medicine
Background The dysfunction of the immune system is one of the pathogeneses of endometriosis. Immune cells can not only affect the microenvironment of the endometrium by secreting cytokines and defensins but also promote angiogenesis, growth and invasion ...
Xiaohong Chang, Zhao Tian, Honglan Zhu, Yiling Wang, Qingjie Zhai   +4 more
doaj   +1 more source

Na ⁺ /K ⁺ -ATPase Modulates Purinergic P2X3 Receptor Function to Drive Bone Cancer Pain

Research
Bone cancer pain (BCP) is one of the most common types of chronic pain in cancer patients, with a prevalence of up to 75%. However, the pathological mechanism and therapeutic approaches are limited. Here, we demonstrated that Na + /K + -ATPase α1 (NKAα1) is a critical regulator of nociception
Songqiang Huang, Bo Peng, Wanting Dong, Jiapeng He, Hanbin Chen, Jin-Song Bian   +5 more
openaire   +3 more sources

The P2X receptor mediated regulation of inhibitory synaptic transmission [PDF]

In the central nervous system ATP can be released by neurons and glial cells through similar pathways as other neurotransmitters. Extracellular ATP targets P2X purinoreceptors, causing an influx of Ca2+ ions which transmit very important messages for ...
Andrew-Adiamah, Jemma
core  

A new role for P2 receptors: talking with calcium-activated potassium channels

, 2007
Purinergic fast synaptic transmission may play a very subtle role in regulating the excitability of enteric circuits. That is one of the important findings in a new paper by Ren and Galligan in the current issue of this Journal.
Bertrand, P. P
core   +1 more source

Radioligands Targeting the Purinergic P2X Receptors

Cells
Purinergic P2X receptors have a wide distribution within the body and modulate a number of physiological processes, being also involved in the development and progression of inflammation-, neuroinflammation-, neurodegeneration-, and cancer-related ...
Diego Dal Ben, Michela Buccioni, Catia Lambertucci, Beatrice Francucci, Aleksei Smirnov, Andrea Spinaci, Gabriella Marucci, Rosaria Volpini   +7 more
doaj   +1 more source

Sensitization of P2X3 receptors in insular cortex contributes to visceral pain of adult rats with neonatal maternal deprivation

Molecular Pain, 2018
Aims Insular cortex is a brain region critical for processing of the sensation. Purinergic receptors are involved in the formation of chronic pain. The aim of the present study was to explore the role and mechanism of P2X3 receptors (P2X3Rs) in insular ...
Ping-An Zhang, Hong-Yan Zhu, Qi-Ya Xu, Wan-Jie Du, Shufen Hu, Guang-Yin Xu   +5 more
doaj   +1 more source