Results 101 to 110 of about 583,778 (211)
BMC Research Notes, 2010 Background Purines such as adenosine and ATP are now generally recognized as the regulators of many physiological functions, such as neurotransmission, pain, cardiac function, and immune responses.
Suzuki Tokiko +2 more
doaj +1 more source
Autocrine purinergic receptor signaling is essential for macrophage chemotaxis.
, 2010 Chemotaxis, the movement of cells along chemical gradients, is critical for the recruitment of immune cells to sites of inflammation; however, how cells navigate in chemotactic gradients is poorly understood.
Sargin, Sarah +25 more
core +1 more source
Virulence, 2018 Epsilon-toxin (ETX) is produced by types B and D strains of Clostridium perfringens, which cause fatal enterotoxaemia in sheep, goats and cattle. Previous studies showed that only a restricted number of cell lines are sensitive to ETX and ETX-induced ...
Jie Gao +10 more
doaj +1 more source
Characteristics of the P2Y 11 nucleotide receptor : ligand binding characteristics and P2Y 11-P2Y 1 receptor [PDF]
, 2007 Purinergic receptors, nucleotides, P2Y, diastereoselectivity, potency, mutagenesis, ligand recognition, heterooligomerization, endocytosis, co-pulldownMagdeburg, Univ., Fak.
Ecke, Denise
core
Purinergic receptor expression in neuronal, bladder smooth muscle and urothelial cells: characterization and inhibition by low molecular weight antagonists [PDF]
, 2009 P2 purinoceptors comprise ionotropic (P2X) and metabotropic (P2Y) receptor families, responsive to nucleotide ligands and diversely distributed on virtually every mammalian cell. Most cells and tissues co-express multiple subtypes of purinoceptor; thus,
Gever, J.L.
core
Purinergic receptors and the inflammatory response mediated by lipids.
, 2019 The inflammatory response is regulated by the production of different extracellular mediators, including lipids and extracellular nucleotides. In the extracellular environment, intermediate lipids activate specific G-protein-coupled receptors (GPCRs) in ...
Pelegrín, Pablo +2 more
core +1 more source
The Purinergic P2Y Receptor Family as Novel Drug Target in Epilepsy
, 2018 Epilepsy is one of the most common chronic neurological diseases and is characterized by recurrent seizures. Despite the existence of numerous anti-epileptic drugs, 30-40% of patients remain drug-refractory. Consequently, we must identify novel target genes with new mechanisms of action.
openaire +1 more source
Expression of purinergic P2 receptors and their role in intracellular calcium signaling of neonatal pituitary cells [PDF]
, 2014 This diploma thesis focuses on study of the expression of purinergic receptors P2X and P2Y in the cells of neonatal adenohypofysis. Purinergic receptors are activated by binding of extracellular ATP and their activation leads to an increase in ...
Šprláková, Katarína
core
, 2007 National audiencePurinergic P2Y-receptor agonists amplify glucose-induced insulin secretion from pancreatic beta-cells, thus offering new opportunities for the treatment of type 2 diabetes.
Gross, René +5 more
core +1 more source
, 2011 Copyright information:Taken from "GPR17: Molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors"http://www.biomedcentral.com/1471-2105/9/263BMC Bioinformatics 2008;9():263-263 ...
Chiara Parravicini (90367) +3 more
core +1 more source