Results 91 to 100 of about 583,778 (211)

P2Y2 receptor knock-out mice display normal NaCl absorption in medullary thick ascending limb

Frontiers in Physiology, 2013
Local purinergic signals modulate renal tubular transport. Acute activation of renal epithelial P2 receptors causes inhibition of epithelial transport and thus, should favor increased water and salt excretion by the kidney. So far only a few studies have
Rita Delgado Marques, Helle A. Praetorius, Jens eLeipziger   +2 more
doaj   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, Volume 13, Issue 38, 9 July 2026.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

Purinergic signalling: past, present and future [PDF]

, 2009
The discovery of non-adrenergic, non-cholinergic neurotransmission in the gut and bladder in the early 1960's is described as well as the identification of adenosine 5'-triphosphate (ATP) as a transmitter in these nerves in the early 1970's.
G. Burnstock, Burnstock, G
core  

ADP receptor P2Y(13) induce apoptosis in pancreatic beta-cells.

, 2010
Pancreatic beta-cell loss represents a key factor in the pathogenesis of diabetes. Since the influence of purinergic signaling in beta-cell apoptosis has not been much investigated, we examined the role of the ADP receptor P2Y(13) using the pancreatic ...
Erlinge, David,, Svensson, Siv, Tan, Chanyuan, Salehi, S Albert, Erlinge, David, Svensson, Siv,, Olde, Björn,, Olde, Björn, Lund University., Tan, Chanyuan,   +9 more
core   +1 more source

Purinergic GPCR transmembrane residues involved in ligand recognition and dimerization

, 2021
We compare the GPCR-ligand interactions and highlight important residues for recognition in purinergic receptors—from both X-ray crystallographic and cryo-EM structures.
Shanu Jain, Veronica Salmaso, Jacobson, Kenneth A., Jain, Shanu, Jain S., Salmaso, Veronica, Kenneth A. Jacobson, Jacobson K. A., Salmaso V.   +8 more
core   +1 more source

Editorial: Purinergic Pharmacology [PDF]

, 2019
The purine nucleotides and nucleosides constitute important extracellular signaling molecules acting as neurotransmitters and neuromodulators. Indeed, extracellular adenosine 5′-triphosphate (ATP) and adenosine, tightly controlled by nucleotidases ...
Jacobson, Kenneth A., Ciruela Alférez, Francisco, Francisco Ciruela, Kenneth A. Jacobson   +3 more
core   +1 more source

Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia

Journal of Neuroinflammation, 2009
Microglia are implicated in multiple neurodegenerative disorders, many of which display sexual dimorphisms and have symptom onsets at different ages. P2 purinergic receptors are critical for regulating various microglial functions, but little is known ...
Nikodemova Maria, Crain Jessica M, Watters Jyoti J   +2 more
doaj   +1 more source

P2X and P2Y receptor signaling in red blood cells

Frontiers in Molecular Biosciences, 2015
Purinergic signaling involves the activation of cell surface P1 and P2 receptors by extracellular nucleosides and nucleotides such as adenosine and adenosine triphosphate (ATP), respectively.
Ronald eSluyter, Ronald eSluyter, Ronald eSluyter   +2 more
doaj   +1 more source

P2 purinergic receptors of human eosinophils: characterization and coupling to oxygen radical production

, 2000
Extracellular nucleotides elicit multiple responses in eosinophils but no information on expression of purinergic receptors in these cells is available so far. In the present study we show that human eosinophils express the following P2Y and P2X subtypes:
PURLIS D., VIRCHOW C. J.r., LUTTMANN W., DICHMANN S., NORGAUER J., IDZKO M., Idzko, Marco, Paola Chiozzi, Marco Idzko, Dichmann, Stefan, Francesco Di Virgilio, Davide Ferrari, Luttmann, Werner, Christian Virchow, Virchow, Johann Christian, Daniela Purlis, Werner Luttmann, Stefan Dichmann, Johannes Norgauer, Di Virgilio, F., Norgauer, Johannes, Purlis, Daniela, FERRARI, Davide, DI VIRGILIO, Francesco, CHIOZZI, Paola   +24 more
core   +1 more source

New insights into purinergic receptor signaling in neuronal differentiation, neuroprotection, and brain disorders [PDF]

, 2007
Ionotropic P2X and metabotropic P2Y purinergic receptors are expressed in the central nervous system and participate in the synaptic process particularly associated with acetylcholine, GABA, and glutamate neurotransmission. As a result of activation, the
Trujillo, Cleber Augusto, Gomes, Katia das Neves, Katia N. Gomes, Cleber A. Trujillo, Henning Ulrich, Resende, Rodrigo Ribeiro, Lopes, Camila Galvão, Katia K. Yuahasi, Ulrich, Henning, Rodrigo R. Resende, Paromita Majumder, Luiz R. G. Britto, Majumder, Paromita, Camila G. Lopes, Britto, Luiz Roberto Giorgetti de, Yuahasi, Katia Kioko [UNIFESP]   +15 more
core   +1 more source