Results 211 to 220 of about 57,506 (257)
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Retinoic acid receptors at 35 years
Journal of Molecular Endocrinology, 2022For almost a century, vitamin A has been known as a nutrient critical for normal development, differentiation, and homeostasis; accordingly, there has been much interest in understanding its mechanism of action. This review is about the discovery of specific receptors for the vitamin A derivative, retinoic acid (RA), which launched extensive molecular,
Martin Petkovich, Pierre Chambon
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RETINOIC ACID RECEPTORS AND CANCERS
Annual Review of Nutrition, 2004▪ Abstract Studies utilizing experimental animals, epidemiological approaches, cellular models, and clinical trials all provide evidence that retinoic acid and some of its synthetic derivatives (retinoids) are useful pharmacological agents in cancer therapy and prevention.
Dianne Robert, Soprano +2 more
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2010
Retinoids, a group of structural and functional derivatives of vitamin A are known to regulate a large number of essential biological processes such as cell growth, differentiation and death. The retinoic acid (RA) signalling pathway involves the precise regulation of retinoid levels and the control of RA-dependent gene expression in target cells.
Audrey Cras +2 more
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Retinoids, a group of structural and functional derivatives of vitamin A are known to regulate a large number of essential biological processes such as cell growth, differentiation and death. The retinoic acid (RA) signalling pathway involves the precise regulation of retinoid levels and the control of RA-dependent gene expression in target cells.
Audrey Cras +2 more
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History of Retinoic Acid Receptors
2014The discovery of retinoic acid receptors arose from research into how vitamins are essential for life. Early studies indicated that Vitamin A was metabolized into an active factor, retinoic acid (RA), which regulates RNA and protein expression in cells.
Doris M, Benbrook +3 more
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Retinoic Acid Receptors in Hematopoiesis
1996Retinoic acid receptors (RARs) are critical transcriptional regulators that are involved in the development and differentiation of a wide variety of different cells (Evans 1988). Several lines of evidence suggest that RARs may be involved in the regulation of hematopoiesis.
S J, Collins, S, Tsai, I, Bernstein
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1995
Retinoids, a class of hydrophobic compounds including retinol (vitamin A), retinoic acid (RA) and a series of natural and synthetic derivatives, exhibit a vast array of profound and diverse effects on vertebrate development from early embryogenesis to maturity.
Marie Keaveney, Hendrik G. Stunnenberg
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Retinoids, a class of hydrophobic compounds including retinol (vitamin A), retinoic acid (RA) and a series of natural and synthetic derivatives, exhibit a vast array of profound and diverse effects on vertebrate development from early embryogenesis to maturity.
Marie Keaveney, Hendrik G. Stunnenberg
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Transcriptional Activities of Retinoic Acid Receptors
2005Vitamin A derivatives plays a crucial role in embryonic development, as demonstrated by the teratogenic effect of either an excess or a deficiency in vitamin A. Retinoid effects extend however beyond embryonic development, and tissue homeostasis, lipid metabolism, cellular differentiation and proliferation are in part controlled through the retinoid ...
Lefebvre, P. +5 more
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Retinoic acid and its receptors
The American Journal of Surgery, 1993Retinoic acid (RA)--the active metabolite of vitamin A--and its analogues have pleiotropic effects on growth, differentiation, proliferation, and development. RA, and its analogues, determine embryonic pattern formation and inhibit tumor growth; however, they are also teratogens.
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Retinoids, Retinoic Acid Receptors, and Cancer
Annual Review of Pathology: Mechanisms of Disease, 2011Retinoids (i.e., vitamin A, all-trans retinoic acid, and related signaling molecules) induce the differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but not all of the effects of retinoids. Retinoid signaling is often compromised early in carcinogenesis, which suggests that a reduction in retinoid signaling may ...
Xiao-Han, Tang, Lorraine J, Gudas
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Dominant negative retinoic acid receptor β
Mechanisms of Development, 1993Induction of the retinoic acid receptor beta 2 (RAR beta 2) gene by retinoic acid (RA) is mediated by a RA response element (RARE), which represents a high affinity binding site for RAR/RXR heterodimers acting at this site as RA-inducible transcription activators.
S, Shen, P T, van der Saag, W, Kruijer
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