Results 61 to 70 of about 56,954 (204)

Somatostatin Receptor 2–Targeting Compounds [PDF]

Journal of Nuclear Medicine, 2017
The molecular imaging and treatment of neuroendocrine tumors (NETs) with radiolabeled somatostatin analogs represent a milestone in the development of theranostic compounds. Whole-body scintigraphy with 111In-pentetreotide has revolutionized the diagnosis and staging of NETs and the evaluation of treatment outcomes. At present, diagnostic accuracy with
Smit Duijzentkunst, Daniël, Kwekkeboom, Dik, Bodei, L   +2 more
openaire   +3 more sources

Lutathera^®: The First FDA- and EMA-Approved Radiopharmaceutical for Peptide Receptor Radionuclide Therapy

Pharmaceuticals, 2019
As the first radiopharmaceutical for Peptide Receptor Radionuclide Therapy (PRRT), Lutathera® was approved by the EMA in 2017 and the FDA in 2018 for the treatment of somatostatin receptor (SSTR) positive gastroenteropancreatic neuroendocrine tumors.
Ute Hennrich, Klaus Kopka
doaj   +1 more source

Pulmonary large cell neuroendocrine carcinoma (LCNEC) with confirmed liver metastases negative on 18F-FDG and 68Ga-DOTATATE PET

Radiology Case Reports, 2020
Lung neuroendocrine neoplasms (NENs) encompass the low-, intermediate-, and high-grade entities. Differentiated NENs overexpress somatostatin receptors, which are targeted by 68Ga-DOTA-conjugated peptides in molecular imaging with positron emission ...
Gaia Ninatti, Heying Duan, MD, Valentina Ferri, MS, Brock A. Martin, MD, Carina Mari Aparici, MD   +4 more
doaj   +1 more source

Somatostatin and Somatostatin Receptors in Tumour Biology

International Journal of Molecular Sciences, 2023
Somatostatin (SST), a growth hormone inhibitory peptide, is expressed in endocrine and non-endocrine tissues, immune cells and the central nervous system (CNS). Post-release from secretory or immune cells, the first most appreciated role that SST exhibits is the antiproliferative effect in target tissue that served as a potential therapeutic ...
openaire   +2 more sources

Mirtazapine decreases stimulatory effects of reboxetine on cortisol, adrenocorticotropin and prolactin secretion in healthy male subjects [PDF]

, 2004
Reboxetine is a selective noradrenaline reuptake inhibitor, whereas mirtazapine acts as an antagonist at noradrenergic alpha(2), serotonin (5-HT2), 5-HT3 and histamine H-1 receptors.
Baghai, Thomas C., Laakmann, G., Schule, C.   +2 more
core   +1 more source

Somatostatin receptors in fibrotic myocardium.

PLoS ONE
A patient with a neuroendocrine tumor and history of coronary artery disease underwent PET with 68Ga-DOTATATE PET tracer for tumor visualization.
Estibaliz Castillero, Chiara Camillo, W Clinton Erwin, Sameer Singh, Nafisa Mohamoud, Isaac George, Elizabeth Eapen, Keith Dockery, Giovanni Ferrari, Himanshu Gupta   +9 more
doaj   +1 more source

Somatostatinergic systems: an update on brain functions in normal and pathological aging

Frontiers in Endocrinology, 2012
Somatostatin is highly expressed in mammalian brain and is involved in many brain functions such as motor activity, sleep, sensory and cognitive processes. Five somatostatin receptors have been described: sst1, sst2 (A and B), sst3 to 5, all belonging to
Guillaume eMartel, Guillaume eMartel, Patrick eDutar, Patrick eDutar, Jacques eEpelbaum, Jacques eEpelbaum, Cécile eViollet, Cécile eViollet   +7 more
doaj   +1 more source

Radioiodinated somatostatin analogue RC-160: preparation, biological activity, in vivo application in rats and comparison with [123I-Tyr3]octreotide [PDF]

, 1993
We have evaluated the potential usefulness of the radioiodinated octapeptide RC-160, a somatostatin analogue, which might serve as a radiopharmaceutical for the in vivo detection of somatostatin receptor-positive tumours. For this purpose, iodine-123 and
Bakker, W.H. (Willem), Breeman, W.A.P. (Wouter), Hofland, L.J. (Leo), Jong, M. (Marcel) de, Koetsveld, P.M. (Peter) van, Krenning, E.P. (Eric), Kwekkeboom, D.J. (Dirk Jan), Lamberts, S.W.J. (Steven), Pluij, M. (M.) van der, Setyono-Han, B. (Buddy), Visser, T.J. (Theo)   +10 more
core   +1 more source

Somatostatin receptor imaging. the presence of somatostatin receptors in rheumatoid arthritis [PDF]

Arthritis & Rheumatism, 1994
AbstractObjective. To investigate the in vivo and in vitro expression of somatostatin receptors (SS‐R) on synovial membranes of patients with rheumatoid arthritis (RA).Methods. The joints of 14 consecutive patients with active RA, 4 patients with severe osteoarthritis (OA), and 30 control patients were studied.
P M, Vanhagen, H M, Markusse, S W, Lamberts, D J, Kwekkeboom, J C, Reubi, E P, Krenning   +5 more
openaire   +2 more sources

Cholecystokinin and Somatostatin Negatively Affect Growth of the Somatostatin-RIN-14B Cells

International Journal of Endocrinology, 2009
With the exclusive presence of the pancreatic CCK-2 receptors on the pancreatic delta cells of six different species, this study was undertaken to determine the role of cholecystokinin and gastrin on growth of these somatostatin (SS) cells.
Karim El-Kouhen, Jean Morisset
doaj   +1 more source