Results 101 to 110 of about 563,890 (226)
FEBS Open Bio, Volume 16, Issue 9, Page 1825-1839, September 2026.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Role of thromboxane receptors in Forssman shock in guinea pigs
, 1989 Forssman shock is a bronchospastic reaction mounted in guinea pigs on intravenous administration of an antiserum obtained from rabbits immunized against sheep erythrocytes.
W. A. Schumacher +3 more
core +1 more source
Platelets, 2018 The podoplanin-CLEC-2 axis is critical in mice for prevention of hemorrhage in the cerebral vasculature during mid-gestation. This raises the question as to how platelets are captured by podoplanin on neuroepithelial cells in a high shear environment. In
Stephanie E. Lombard +6 more
doaj +1 more source
Advanced Healthcare Materials, Volume 15, Issue 34, 11 September 2026.A microfluidic device with magnetic microposts was used to assess platelet mechanobiology. The oscillatory actuation of posts with embedded iron particles was dampened by the dynamic stiffening of the platelet‐rich plugs. This stiffening process increased with applied load, but inhibiting platelet activation (ASA) or myosin contractility (blebbistatin)
Nikita Taparia +4 more
wiley +1 more source
Thromboxane A2/endoperoxide receptors mediate cholinergic constriction of rabbit lung microvessels
, 1992 Using an X-ray television system, we directly measured the internal diameter (ID; 100–1,000 microns) of small pulmonary arteries and analyzed the effects of cyclooxygenase inhibition and thromboxane A2/prostaglandin endoperoxide (TP) receptor blockade ...
K. Sada, M. Shirai, I. Ninomiya
core +1 more source
Mechanistic Pathways of Wound Healing: From Hemostasis to Scar‐Free Regeneration
Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.ABSTRACT Wound healing is the critical process regulated through a harmonious coordination of cellular, molecular, pathological, and systemic communications. Normally, healing occurs in four overlapping phases, which are modified and controlled by various growth factor interactions and signaling pathways.
Devadass Jessy Mercy +2 more
wiley +1 more source
Growth factors downregulate vascular smooth muscle thromboxane receptors independent of cell growth
, 1992 Growth factors, in addition to being mitogenic, may modulate vascular smooth muscle differentiation. We tested whether serum or defined growth factors could regulate thromboxane A2 (TxA2) receptors in cultured rabbit aorta smooth muscle cells.
M. W. Becker, G. W. Dorn
core +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.Emodin improves white matter remyelination and alleviates cognitive deficits through suppression of the RAGE/ROCK1 signaling pathway in VD rats. Mechanistically, it modulates the OL lineage by reducing the elevated proliferative response of OPCs while promoting their maturation and remyelination.
Xueqing Wang +7 more
wiley +1 more source
Modification of the rat uterine response to oestrogen and tamoxifen by thromboxane antagonists
, 1991 The thromboxane receptor antagonists EP092, AH23848 and BM 13.505 were used to investigate the role of thromboxane in the uterotrophic response to oestradiol and tamoxifen.
Kerr, M.B. +2 more
core +4 more sources
Health Science Reports, Volume 9, Issue 9, September 2026.ABSTRACT Background and Aims Cardiovascular diseases (CVDs) remain the leading cause of global morbidity and mortality, encompassing coronary artery disease, hypertension, heart failure, and cerebrovascular disorders. The global burden of CVD continues to rise, driven by complex interactions among endothelial dysfunction, oxidative stress, inflammation,
Nawfal Hasan Siam +8 more
wiley +1 more source