Results 11 to 20 of about 10,497,311 (290)

Cutting Edge: Lymphocyte Inhibitor of TRAIL (TNF-Related Apoptosis-Inducing Ligand): A New Receptor Protecting Lymphocytes from the Death Ligand TRAIL

The Journal of Immunology, 1998
Abstract Apoptosis can be triggered by the engagement of cell surface receptors by their ligands. A growing number of receptors belonging to the TNF receptor family have been identified that contain a conserved cytoplasmic death domain.
Mongkolsapaya, Juthathip, Cowper, Alison E., Xu, Xiao Ning, Morris, Gwilym, McMichael, Andrew J., Bell, John I., Screaton, Gavin R.   +6 more
core   +16 more sources

Differential Localization and Regulation of Death and Decoy Receptors for TNF-Related Apoptosis-Inducing Ligand (TRAIL) in Human Melanoma Cells [PDF]

The Journal of Immunology, 2000
Abstract Induction of apoptosis in cells by TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF family, is believed to be regulated by expression of two death-inducing and two inhibitory (decoy) receptors on the cell surface.
Zhang, X. D., Franco, A. V., Nguyen, T., Gray, C. P., Hersey, P.   +4 more
openaire   +6 more sources

Volatile oil of Teucrium alopecurus sensitizes colon cancer cells to TRAIL-induced cell death

Frontiers in Bioscience-Scholar, 2021
TNF-related apoptosis-inducing ligand (TRAIL/Apo2L), a member of cytokine family, is known to selectively induce apoptosis in cancer cells. However, developing resistance to TRAIL is a major obstacle in cancer therapy.
Fatma Guesmi, Sahdeo Prasad, Wiem Tahri, Imen Dridi, Manel Ben Ali, Amor Hedfi, Ismail A. Ismail, Ahmed Landoulsi   +7 more
doaj   +1 more source

3-Dimensional Model to Study Apoptosis Induction of Activated Natural Killer Cells Conditioned Medium Using Patient-Derived Colorectal Cancer Organoids

Frontiers in Cell and Developmental Biology, 2022
Natural killer (NK) cells are innate lymphocytes that can kill tumor cells via different pathways, including the secretion of cytotoxic granules in immunological synapses and the binding of apoptosis-inducing ligands with cognate death receptors on tumor
Benyamin Parseh, Benyamin Parseh, Ayyoob Khosravi, Ayyoob Khosravi, Abdolreza Fazel, Jafar Ai, Somayeh Ebrahimi-Barough, Javad Verdi, Majid Shahbazi   +8 more
doaj   +1 more source

Fetal-derived trophoblast use the apoptotic cytokine tumor necrosis factor-alpha-related apoptosis-inducing ligand to induce smooth muscle cell death. [PDF]

, 2007
Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential to meet the demand for increased blood flow imposed by the growing fetus. Loss
Cartwright, JE, Aplin, JD, Whitley, GS, Keogh, RJ, Freeman, A, Harris, LK, Baker, PN   +6 more
core   +1 more source

Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines [PDF]

, 2009
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis on binding to its receptors, death receptor 4 and 5 (DR4, DR5).
M Keane, Mehmet, H, A Samali, D Mahalingam, H Mehmet, Mahalingam, D, E Szegezdi, Szegezdi, E, Keane, M, G Pirianov, Pirianov, G, Samali, A   +11 more
core   +1 more source

Expression of TNF-related apoptosis-inducing Ligand receptors and antitumor tumor effects of TNF-related apoptosis-inducing Ligand in human hepatocellular carcinoma

World Journal of Gastroenterology, 2003
To investigate the expression of TNF-related apoptosis -inducing Ligand (TRAIL) receptors and antitumor effects of TRAIL in hepatocellular carcinoma (HCC).Expression of TRAIL receptors was determined in 60 HCC tissues, 20 normal liver samples and two HCC cell lines (HepG2 and SMMC-7721).
Xiao-Ping, Chen, Song-Qing, He, Hai-Ping, Wang, Yong-Zhong, Zhao, Wan-Guang, Zhang   +4 more
openaire   +2 more sources

Microsatellite instability, KRAS mutations and cellular distribution of TRAIL-receptors in early stage colorectal cancer. [PDF]

, 2012
Thus, we evaluated the immunofluorescence pattern of TRAIL-receptors and E-cadherin to assess the fraction of membrane-bound TRAIL-receptors in 231 selected patients with early-stage CRC undergoing surgical treatment only.
Göke, Burkhard, Thomas Kirchner (109827), Rene Jackstadt, Gallmeier, Eike, Thomas Kirchner, Gerbes, Alexander L., Kriegl, Lydia, Eike Gallmeier, Jackstadt, Rene, Alexander L Gerbes, Burkhard Göke (109829), De Toni, Enrico N., Eike Gallmeier (109823), Enrico N De Toni, Burkhard Göke, Horst, David, Andreas Jung, Rene Jackstadt (109815), David Horst, Jung, Andreas, Antonia Rizzani (109811), Heiko Hermeking (109819), Alexander L. Gerbes (109825), Kirchner, Thomas, Andreas Jung (109804), David Horst (109808), Enrico N. De Toni (109830), Lydia Kriegl, Rizzani, Antonia, Hermeking, Heiko, Heiko Hermeking, Lydia Kriegl (109801), Antonia Rizzani   +32 more
core   +2 more sources

Grafting TRAIL through Either Amino or Carboxylic Groups onto Maghemite Nanoparticles: Influence on Pro-Apoptotic Efficiency

Nanomaterials, 2021
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF cytokine superfamily. TRAIL is able to induce apoptosis through engagement of its death receptors DR4 and DR5 in a wide variety of tumor cells while sparing ...
Hanene Belkahla, Andrei Alexandru Constantinescu, Tijani Gharbi, Florent Barbault, Alexandre Chevillot-Biraud, Philippe Decorse, Olivier Micheau, Miryana Hémadi, Souad Ammar   +8 more
doaj   +1 more source

Implicación de NF-κB y p53 en la expresión de receptores de muerte-TRAIL y apoptosis por procianidinas en células metastásicas humanas SW620

Biomédica: revista del Instituto Nacional de Salud, 2010
Introducción. Se ha demostrado que el factor nuclear-κB y p53 aumentan los mediadores proapoptósicos como los receptores de muerte TRAIL-DR4/-DR5, según el estímulo y el tipo celular. Previamente demostramos que las procianidinas de manzana aumentaban la
María Elena Maldonado, Souad Bousserouel, Francine Gossé, Annelise Lobstein, Francis Raul   +4 more
doaj   +1 more source