Results 21 to 30 of about 10,497,311 (290)

Macrophage-evading and tumor-specific apoptosis inducing nanoparticles for targeted cancer therapy

Acta Pharmaceutica Sinica B, 2023
Extended circulation of anticancer nanodrugs in blood stream is essential for their clinical applications. However, administered nanoparticles are rapidly sequestered and cleared by cells of the mononuclear phagocyte system (MPS).
Zimo Liu, Xuefei Zhou, Qi Li, Youqing Shen, Tianhua Zhou, Xiangrui Liu   +5 more
doaj   +1 more source

Compartmentalization of TNF-related apoptosis-inducing ligand (TRAIL) death receptor functions: emerging role of nuclear TRAIL-R2 [PDF]

Cell Death & Disease, 2014
Localized in the plasma membrane, death domain-containing TNF-related apoptosis-inducing ligand (TRAIL) receptors, TRAIL-R1 and TRAIL-R2, induce apoptosis and non-apoptotic signaling when crosslinked by the ligand TRAIL or by agonistic receptor-specific antibodies.
Bertsch, U, Röder, C, Kalthoff, H, Trauzold, A   +3 more
openaire   +2 more sources

The TNFSF Members APRIL and BAFF and Their Receptors TACI, BCMA, and BAFFR in Oncology, With a Special Focus in Breast Cancer

Frontiers in Oncology, 2020
Tumor necrosis factor (TNF) superfamily consists of 19 ligands and 29 receptors and is related to multiple cellular events from proliferation and differentiation to apoptosis and tumor reduction. In this review, we overview the whole system, and we focus
Marilena Kampa, George Notas, Efstathios N. Stathopoulos, Andreas Tsapis, Elias Castanas   +4 more
doaj   +1 more source

Targeting TNF-related apoptosis-inducing ligand (TRAIL) receptor by natural products as a potential therapeutic approach for cancer therapy [PDF]

Experimental Biology and Medicine, 2015
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to selectively induce apoptotic cell death in various tumor cells by engaging its death-inducing receptors (TRAIL-R1 and TRAIL-R2). This property has led to the development of a number of TRAIL–receptor agonists such as the soluble recombinant TRAIL and agonistic antibodies,
Dai, X., Zhang, J., Arfuso, Frank, Chinnathambi, A., Zayed, M., Alharbi, S., Kumar, A., Ahn, K., Sethi, G.   +8 more
openaire   +3 more sources

Pioglitazone inhibits growth of carcinoid cells and promotes TRAIL-induced apoptosis by induction of p21(waf1/cip1) [PDF]

, 2001
Background/Aims: We investigated the effect of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist pioglitazone on growth and TRAIL-induced apoptosis in carcinoid cells.
Göke, Burkhard, Göke, Rüdiger, Chen, Youhai, El-Deiry, Wafik S., Göke, Alexandra   +4 more
core   +1 more source

miR-25 Targets TNF-Related Apoptosis Inducing Ligand (TRAIL) Death Receptor-4 and Promotes Apoptosis Resistance in Cholangiocarcinoma [PDF]

Hepatology, 2012
Abstract It has been established that microRNA expression and function contribute to phenotypic features of malignant cells, including resistance to apoptosis. Although targets and functional roles for a number of microRNAs have been described in cholangiocarcinoma, many
Razumilava, Nataliya, Bronk, Steve F., Smoot, Rory L., Fingas, Christian D., Werneburg, Nathan W., Roberts, Lewis R., Mott, Justin L.   +6 more
openaire   +3 more sources

TRAIL Modulates the Immune System and Protects against the Development of Diabetes

Journal of Immunology Research, 2015
TRAIL or tumor necrosis factor (TNF) related apoptosis-inducing ligand is a member of the TNF superfamily of proteins, whose best characterized function is the induction of apoptosis in tumor, infected, or transformed cells through activation of specific
Fleur Bossi, Stella Bernardi, Giorgio Zauli, Paola Secchiero, Bruno Fabris   +4 more
doaj   +1 more source

BCR-ABL regulates death receptor expression for TNF-related apoptosis-inducing ligand (TRAIL) in Philadelphia chromosome-positive leukemia [PDF]

Oncogene, 2011
Abstract Abstract 2740 Allogeneic stem cell transplantation (allo-SCT) is potentially curative therapy for CML and Ph+ ALL patients. Graft-versus-leukemia (GVL) effect plays a central role in eradication of residual leukemia after allo-SCT, and GVL effect is mediated by cytotoxic T-lymphocytes (CTLs) and NK cells though ...
I, Kuroda, T, Inukai, X, Zhang, J, Kikuchi, Y, Furukawa, A, Nemoto, K, Akahane, K, Hirose, H, Honna-Oshiro, K, Goi, K, Kagami, H, Yagita, T, Tauchi, Y, Maeda, K, Sugita   +14 more
openaire   +2 more sources

Changes in expression of TNF alpha and its receptors mRNAs in oocytes and granulosa cells in mice with experimental immune ovarian failure [PDF]

, 2014
Purpose: To investigate the expression of TNF- α and its receptors (types I and II) at mRNA level in oocytes and granulose cells as well as to study effect of TNF-α on follicular cell death in mice with experimental immune ovarian failure induced by ...
Grushka, Nataliya, Dosenko, Victor, Shepel, Elena, Voznesenskaya, Tatyana, Yanchiy, Roman   +4 more
core   +1 more source

Antibodies and Derivatives Targeting DR4 and DR5 for Cancer Therapy

Antibodies, 2017
Developing therapeutics that induce apoptosis in cancer cells has become an increasingly attractive approach for the past 30 years. The discovery of tumor necrosis factor (TNF) superfamily members and more specifically TNF-related apoptosis-inducing ...
Agathe Dubuisson, Olivier Micheau
doaj   +1 more source