Molecular cloning, expression analysis and assignment of the porcine tumor necrosis factor superfamily member 10 gene (TNFSF10) to SSC13q34 -> q36 by fluorescence in situ hybridization and radiation hybrid mapping [PDF]
, 2005 We have cloned the complete coding region of the porcine TNFSF10 gene. The porcine TNFSF10 cDNA has an ORF of 870 nucleotides and shares 85 % identity with human TNFSF10, and 75% and 72% identity with rat and mouse Tnfsf10 coding sequences, respectively.
Kemter, E. +15 more
core +2 more sources
Role Of S-Nitrosylation In The Extrinsic Apoptotic Signalling Pathway In Cancer
Redox Biology, 2015 One of the key features of tumour cells is the acquisition of resistance to apoptosis. Thus, determining therapeutic strategies that circumvent apoptotic resistance and result in tumor regression is a challenge.
Stéphanie Plenchette
doaj +1 more source
Hepatitis C virus sensitizes host cells to TRAIL-induced apoptosis by up-regulating DR4 and DR5 via a MEK1-dependent pathway. [PDF]
PLoS ONE, 2012 BACKGROUND: Hepatitis C virus (HCV) is the leading cause of liver fibrosis, cirrhosis and hepatocellular carcinoma. It is believed that continuous liver cell apoptosis contributes to HCV pathogenesis.
Zhongfan Deng +6 more
doaj +1 more source
CHRYSIN MENINGKATKAN EFEK SITOTOKSIK TNF-RELATED APOPTOSIS-INDUCING LIGAND TERHADAP SEL HEK293 [PDF]
, 2017 -TNF-related apoptosis-inducing ligand merupakan salah satu pilihan pengobatan kanker yang secara efektif dapat menginduksi apoptosis melalui aktivasi death receptor (DR4 dan DR5). Penggunaan TNF-related apoptosis-inducing ligand menyebabkan efek samping
habibie, habibie
core +1 more source
Downregulation of endogenous TRAIL and its effect on the human cancer cell line KELLY [PDF]
, 2011 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to exert an unexpected pro-survival, pro-proliferative and pro-invasive effect on a subset of human cancer cell lines. Recent clinical studies report that increased expression
Brittingham, Sara
core +1 more source
Journey of TRAIL from bench to bedside and its potential role in immuno-oncology
Oncology Reviews, 2017 Induction of apoptosis in cancer cells has increasingly been the focus of many therapeutic approaches in oncology field. Since its identification as a TNF family member, TRAIL (TNF-related apoptosis-inducing ligand) paved a new path in apoptosis inducing
George E. Naoum +4 more
doaj +1 more source
Pharmaceutics, 2023 The TRAIL (TNF-related apoptosis-inducing ligand) apoptotic pathway is extensively exploited in the development of targeted antitumor therapy due to TRAIL specificity towards its cognate receptors, namely death receptors DR4 and DR5.
Anne V. Yagolovich +2 more
doaj +1 more source
Redox Biology, 2021 Aims: Preferential expression of receptors for TNF-family related apoptosis inducing ligand (TRAIL), DR4 and DR5 makes TRAIL an attractive anti-cancer therapeutic.
Deepika Raman +4 more
doaj +1 more source
Expression of osteoprotegerin (OPG), TNF related apoptosis inducing ligand (TRAIL), and receptor activator of nuclear factor κB ligand (RANKL) in human breast tumours [PDF]
Journal of Clinical Pathology, 2006 Background: Osteoprotegerin (OPG) is involved in the regulation of bone turnover through binding to the receptor activator of nuclear factor κB ligand (RANKL), and has also been reported to be a potential survival factor for several different cell types.
C, Van Poznak +7 more
openaire +2 more sources
Does DcR1 (TNF-related apoptosis-inducing-ligand Receptor 3) have any role in human AMD pathogenesis? [PDF]
Scientific Reports, 2014 It has been postulated that there is a link between age related degenerative diseases and cancer. The TNF-related apoptosis-inducing ligand (TRAIL) has been shown to selectively kill tumor cells by binding to pro-apoptotic and anti-apoptotic receptors. Our aim was to study the levels of anti-apoptotic receptor (DcR1) in age related macular degeneration
Anand, Akshay +8 more
openaire +2 more sources