Results 91 to 100 of about 26,499 (240)

Integrin-uPAR signaling leads to FRA-1 phosphorylation and enhanced breast cancer invasion

Breast Cancer Research, 2018
Background The Fos-related antigen 1 (FRA-1) transcription factor promotes tumor cell growth, invasion and metastasis. Phosphorylation of FRA-1 increases protein stability and function.
Matthew G. Annis, Veronique Ouellet, Jonathan P. Rennhack, Sylvain L’Esperance, Claudine Rancourt, Anne-Marie Mes-Masson, Eran R. Andrechek, Peter M. Siegel   +7 more
doaj   +1 more source

Full-length soluble urokinase plasminogen activator receptor down-modulates nephrin expression in podocytes [PDF]

, 2015
Increased plasma level of soluble urokinase-type plasminogen activator receptor (suPAR) was associated recently with focal segmental glomerulosclerosis (FSGS).
Alfano, Massimo, Cinque, Paola, Giusti, Guido, Proietti, Silvia, Nebuloni, Manuela, Danese, Silvio, D'Alessio, Silvia, Genua, Marco, Portale, Federica, Lo Porto, Manuela, Singhal, Pravin C, Rastaldi, Maria Pia, Saleem, Moin A, Mavilio, Domenico, Mikulak, Joanna   +14 more
core   +2 more sources

Hippocampus-specific deletion of tissue plasminogen activator “tPA” in adult mice impairs depression- and anxiety-like behaviors [PDF]

, 2012
Anxiety and depression are multifactorial disorders that have become prominent health problems all over the world. Neurotrophic factors have emerged underlying pathogenesis of these diseases.
Bahi, Amine, Dreyer, Jean-Luc
core   +1 more source

The structure of the urokinase-type plasminogen activator receptor gene [PDF]

Blood, 1994
The cellular receptor for urokinase-type plasminogen activator (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored membrane protein that plays a central role in pericellular plasminogen activation. It contains 313 amino acid residues, including 28 cysteine residues in a pattern of three homologous repeats. The cysteine residue pattern suggests that
J R, Casey, J G, Petranka, J, Kottra, D E, Fleenor, W F, Rosse   +4 more
openaire   +3 more sources

A personal 360° view of applications of ‘biomimetic’ molecular recognition

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley   +1 more source

Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients [PDF]

, 2002
BACKGROUND: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are associated with poor prognosis in breast cancer patients ...
Beex, L.V. (Louk), Bendahl, P.O., Blankenstein, M.A. (Marinus), Borstnar, S., Broet, P., Brunner, N., Christensen, I.J., Cufer, T., Daver, A., Daxenbichler, G., Duffy, M.J. (Michael), Duggan, C., Eppenberger, U., Eppenberger-Castori, S. (Serenella), Ferno, M., Fiets, W.E., Foekens, J.A. (John), Harbeck, N. (Nadia), Janicke, F., Kates, R. (Ronald), Klijn, J.G.M. (Jan), Kueng, W., Lisboa, B.W., Look, M.P. (Maxime), Magdelenat, H., Manders, P. (Peggy), Martin, P.M., Meijer van Gelder, M.E. (Marion), O'Higgins, N., Peyrat , J.P., Putten, W.L.J. (Wim) van, Quillien, V., Ricolleau, G., Romain, S., Schmitt, M. (Manfred), Spyratos, F., Sweep, C.G., Thomssen, C. (Christoph), Ulm, K., Windbichler, G.   +39 more
core   +1 more source

Soluble Urokinase Plasminogen Activator Receptor Measurements: Influence of Sample Handling [PDF]

The International Journal of Biological Markers, 2001
Aim The influence of sample handling on soluble urokinase plasminogen activator receptor (suPAR) concentrations in serum and EDTA plasma was studied in 16 healthy premenopausal women. Method Blood was collected in dry tubes and tubes containing EDTA and kept at 4°C or 20°C for 1, 3, 8, 24 or 72 hours before processing into serum or EDTA plasma.
R, Riisbro, I J, Christensen, C, Høgdall, N, Brünner, E, Høgdall   +4 more
openaire   +2 more sources

Oncogenic H‐Ras Reprograms Madin‐Darby Canine Kidney (MDCK) Cell‐Derived Midbody Remnant Proteome Following Epithelial‐Mesenchymal Transition

PROTEOMICS, EarlyView.
ABSTRACT Epithelial‐mesenchymal transition (EMT) is a fundamental, dynamic cellular process involved in embryonic development, metastasis, organ fibrosis, and tissue regeneration. To define the molecular landscape of secreted midbody remnants (MBRs) to the EMT process, a proteome analysis of MBRs released from Madin–Darby canine kidney (MDCK) cells and
Adnan Shafiq, Alin Rai, Rong Xu, Maoshan Chen, Wittaya Suwakulsiri, David W. Greening, Richard J. Simpson   +6 more
wiley   +1 more source

Advancing Extracellular Vesicle Research: A Review of Systems Biology and Multiomics Perspectives

PROTEOMICS, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐bound vesicles secreted by various cell types into the extracellular space and play a role in intercellular communication. Their molecular cargo varies depending on the cell of origin and its functional state.
Gloria Kemunto, Samaneh Ghadami, Kristen Dellinger   +2 more
wiley   +1 more source

Structural Biology and Protein Engineering of Thrombolytics

Computational and Structural Biotechnology Journal, 2019
Myocardial infarction and ischemic stroke are the most frequent causes of death or disability worldwide. Due to their ability to dissolve blood clots, the thrombolytics are frequently used for their treatment. Improving the effectiveness of thrombolytics
Jan Mican, Martin Toul, David Bednar, Jiri Damborsky   +3 more
doaj   +1 more source