Results 21 to 30 of about 12,163 (157)
Frontiers in Immunology, 2022 Tuberculosis is one of the deadliest infectious diseases and a huge healthcare burden in many countries. New vaccines, including recombinant BCG-based candidates, are currently under evaluation in clinical trials.
Luana Moraes +9 more
doaj +1 more source
Recombinant BCG Overexpressing phoP-phoR Confers Enhanced Protection against Tuberculosis. [PDF]
Mol Ther, 2018 The live tuberculosis vaccine Mycobacterium bovis BCG (Bacille Calmette-Guérin) comprises a number of genetically distinct substrains. In BCG-Prague, phoP of the PhoP-PhoR two-component system is a pseudogene due to a single insertion mutation. We hypothesized that this mutation partially accounts for the low immunogenicity of BCG-Prague observed in ...
Ahn SK +6 more
europepmc +4 more sources
Recombinant Mycobacterium bovis BCG
Vaccine, 2009 The Bacillus Calmette-Guerin (BCG) is an attenuated strain of Mycobacterium bovis that has been broadly used as a vaccine against human tuberculosis. This live bacterial vaccine is able to establish a persistent infection and induces both cellular and humoral immune responses. The development of mycobacterial genetic systems to express foreign antigens
Reginaldo G, Bastos +3 more
openaire +2 more sources
Sleeping Beauty and the Story of the Bacille Calmette-Guérin Vaccine
mBio, 2016 Mycobacterium bovis BCG is the only available vaccine for protection against tuberculosis (TB). While BCG protects children from severe disease, it has little impact on pulmonary disease in adults. A recombinant BCG vaccine BCG ΔureC::hly (strain VPM1002)
Helen A. Fletcher
doaj +1 more source
Recombinant Mycobacterium bovis BCG as an HIV Vaccine Vector [PDF]
Current HIV Research, 2010 HIV-1 has resulted in a devastating AIDS pandemic. An effective HIV/AIDS vaccine that can be used to either, prevent HIV infection, control infection or prevent progression of the disease to AIDS is needed. In this review we discuss the use of Mycobacterium bovis BCG, the tuberculosis vaccine, as a vaccine vector for an HIV vaccine.
Rosamund, Chapman +4 more
openaire +2 more sources
Vaccines, 2023 Bacillus Calmette–Guérin (BCG) is the only widely used prophylactic tuberculosis (TB) vaccine that can prevent severe TB in infants. However, it provides poor protection in adults, and therefore, there is ongoing research into new TB vaccines and ...
Ruihuan Wang +11 more
doaj +1 more source
The immunogenicity of recombinant Mycobacterium smegmatis bearing BCG genes [PDF]
Microbiology, 1995 SUMMARYSpecific pathogen-free C57BL/6 mice infected with recombinantMycobacterium smegmatis(rM. smegmatis) bearing BCG genes showed increased splenic survival compared to those receiving the vector control (plasmid DNA only). The mouse-passaged rM. smegmatis(J3R) survived in peritoneal macrophages better than the vector control, regardless of whether ...
Valeria, Falcone +3 more
openaire +2 more sources
Recombinant BCG expressing Mycobacterium tuberculosis major extracellular proteins [PDF]
Microbes and Infection, 2005 rBCG30, the first vaccine against tuberculosis demonstrated more potent than BCG in preclinical studies, is the prototype of a class of vaccines that utilize BCG as a host organism for expressing and secreting Mycobacterium tuberculosis major extracellular proteins.
openaire +3 more sources
EB virus-positive tumors are inhibited by rBCG expressing hGM-CSF and LMP2A
Human Vaccines & Immunotherapeutics, 2020 For the development of safe and effective EBV (Epstein-Barr virus) vaccines, the Ag85A signal peptide from M. tuberculosis H37Rv was used to construct a recombinant secretory BCG (Bacillus Chalmette-Guérin) plasmid. The Ag85A gene, fused to the EBV LMP2A
Yingchun Yan +11 more
doaj +1 more source
CHO expressed recombinant human lactoferrin as an adjuvant for BCG [PDF]
International Journal of Immunopathology and Pharmacology, 2015 Lactoferrin (LF), an iron binding protein with immune modulatory activities, has adjuvant activity to enhance vaccine efficacy. Tuberculosis (TB) is a pulmonary disease caused by the pathogen Mycobacterium tuberculosis (MTB). Progressive TB disease is clinically defined by damaging pulmonary pathology, a result of inflammation due to immune reactivity.
Shen-An, Hwang +2 more
openaire +2 more sources