Results 21 to 30 of about 17,679 (284)
RAG: a recombinase diversified [PDF]
Nature Immunology, 2009 During B cell and T cell development, the lymphoid-specific proteins RAG-1 and RAG-2 act together to initiate the assembly of antigen receptor genes through a series of site-specific somatic DNA rearrangements that are collectively called variable-diversity-joining (V(D)J) recombination.
Adam G W, Matthews +1 more
openaire +2 more sources
Recombinase technology: applications and possibilities [PDF]
Plant Cell Reports, 2010 The use of recombinases for genomic engineering is no longer a new technology. In fact, this technology has entered its third decade since the initial discovery that recombinases function in heterologous systems (Sauer in Mol Cell Biol 7(6):2087-2096, 1987).
Yueju Wang +3 more
core +4 more sources
Frontiers in Neuroanatomy, 2017 Central noradrenergic neurons, collectively defined by synthesis of the neurotransmitter norepinephrine, are a diverse collection of cells in the hindbrain, differing in their anatomy, physiological and behavioral functions, and susceptibility to disease
Nicholas W. Plummer +4 more
doaj +1 more source
Stimulation of homologous recombination in plants expressing heterologous recombinases
BMC Plant Biology, 2020 Background Current excitement about the opportunities for gene editing in plants have been prompted by advances in CRISPR/Cas and TALEN technologies. CRISPR/Cas is widely used to knock-out or modify genes by inducing targeted double-strand breaks (DSBs ...
Abdellah Barakate +3 more
doaj +1 more source
Molecules, 2023 RecA family recombinases are the core enzymes in the process of homologous recombination, and their normal operation ensures the stability of the genome and the healthy development of organisms.
Yue Pan +4 more
doaj +1 more source
Making serine integrases work for us [PDF]
, 2017 DNA site-specific recombinases are enzymes (often associated with mobile DNA elements) that catalyse breaking and rejoining of DNA strands at specific points, thereby bringing about precise genetic rearrangements.
Stark, W. Marshall
core +1 more source
Manipulating or superseding host recombination functions: a dilemma that shapes phage evolvability. [PDF]
PLoS Genetics, 2013 Phages, like many parasites, tend to have small genomes and may encode autonomous functions or manipulate those of their hosts'. Recombination functions are essential for phage replication and diversification. They are also nearly ubiquitous in bacteria.
Louis-Marie Bobay +2 more
doaj +1 more source
Controlled rotation mechanism of DNA strand exchange by the Hin serine recombinase. [PDF]
, 2016 DNA strand exchange by serine recombinases has been proposed to occur by a large-scale rotation of halves of the recombinase tetramer. Here we provide the first direct physical evidence for the subunit rotation mechanism for the Hin serine invertase ...
Johnson, Reid C +4 more
core +1 more source
mSphere, 2019 Most urinary tract infections (UTIs) are caused by uropathogenic Escherichia coli (UPEC), which depends on an extracellular organelle (type 1 pili) for adherence to bladder cells during infection.
Colin W. Russell +6 more
doaj +1 more source
BRCA2: a universal recombinase regulator [PDF]
Oncogene, 2007 Homologous recombination has a dual role in eukaryotic organisms. Firstly, it is responsible for the creation of genetic variability during meiosis by directing the formation of reciprocal crossovers that result in random combinations of alleles and traits.
T, Thorslund, S C, West
openaire +2 more sources