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Critical Reviews in Oncology/Hematology, 2009 Rectal cancer is an important tumour from an epidemiological point of view and represents the benchmark for an optimal use of integrated treatments (surgery, radiotherapy and chemotherapy) in the oncological practice. The conventional use of total mesorectal excision and the integration with radiochemotherapy, better if preoperatively, are now able to ...
M. G. Zampino +9 more
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Journal of the Anus, Rectum and Colon, 2023 Objectives: Preventing anastomotic complications during rectal cancer surgery is important. Compared with a manual circular stapler, a powered circular stapler is expected to reduce undesirable tension during anastomosis.
Kenji Nanishi +7 more
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PD-1 Blockade in Mismatch Repair-Deficient, Locally Advanced Rectal Cancer.
New England Journal of Medicine, 2022 BACKGROUND Neoadjuvant chemotherapy and radiation followed by surgical resection of the rectum is a standard treatment for locally advanced rectal cancer. A subset of rectal cancer is caused by a deficiency in mismatch repair.
A. Cercek +31 more
semanticscholar +1 more source
Journal of Clinical Oncology, 2022 PURPOSE To ascertain if preoperative short-term radiotherapy followed by chemotherapy is not inferior to a standard schedule of long-term chemoradiotherapy in patients with locally advanced rectal cancer.
Jing Jin +34 more
semanticscholar +1 more source
Rectal Cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology.
The Journal of the National Comprehensive Cancer Network, 2022 This selection from the NCCN Guidelines for Rectal Cancer focuses on management of malignant polyps and resectable nonmetastatic rectal cancer because important updates have been made to these guidelines.
A. Benson +39 more
semanticscholar +1 more source
Annals of Gastroenterological Surgery, 2022 Aim Sphincter‐preserving operations for ultra‐low rectal cancer include low anterior and intersphincteric resection. In low anterior resection, the distal rectum is divided by a transabdominal approach, which is technically demanding. In intersphincteric
Tadahiro Kojima +7 more
doaj +1 more source
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer.
Cancer Cell, 2022 Standard cancer therapy targets tumor cells without considering possible damage on the tumor microenvironment that could impair therapy response. In rectal cancer patients we find that inflammatory cancer-associated fibroblasts (iCAFs) are associated ...
Adele M. Nicolas +25 more
semanticscholar +1 more source
Annals of Gastroenterological Surgery, 2022 Aim Accurate preoperative diagnosis of lateral lymph node metastasis (LLNM) from lower rectal cancer is important to identify patients who require lateral lymph node dissection (LLND).
Shunsuke Kasai +8 more
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The importance of MRI for rectal cancer evaluation.
Surgical oncology, 2022 Magnetic resonance imaging (MRI) has gained increasing importance in the management of rectal cancer over the last two decades. The role of MRI in patients with rectal cancer has expanded beyond the tumor-node-metastasis (TNM) system in both staging and ...
Maria Clara Fernandes +2 more
semanticscholar +1 more source
Survival and Operative Outcomes After Salvage Surgery for Recurrent or Persistent Anal Cancer [PDF]
Annals of Coloproctology, 2020 Anal squamous cell carcinoma (SCC) is a relatively rare cancer comprising less than 2.5% of all gastrointestinal malignancies. The standard treatment for anal SCC is primary chemoradiation therapy which can result in complete regression. After successful
In Ja Park, George Chang
doaj +1 more source