Results 181 to 190 of about 28,838 (266)

ProteotoxomiRs: Diagnostic and pathologic miRNA signatures for reductive stress induced proteotoxic heart disease. [PDF]

Redox Biol
Karthikeyan SK, Nallasamy P, Cleveland JM, Arulmani A, Raveendran A, Karimi M, Ansari MO, Challa AK, Ponnusamy MP, Benjamin IJ, Varambally S, Rajasekaran NS.   +11 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Exercise mitigates reductive stress-induced cardiac remodeling in mice. [PDF]

Redox Biol
Jyothidasan A, Sunny S, Devarajan A, Sayed A, Afortude JK, Dalley B, Nanda V, Pogwizd S, Litovsky SH, Trinity JD, Might M, Rajasekaran NS.   +11 more
europepmc   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Over-Intake of Plant-Derived Antioxidants, H₂S Generation, and Reductive Stress. Comment on Manzano-Pech et al. The Chronic Elevated Consumption of <i>Hibiscus sabdariffa</i> Linnaeus Results in Kidney Damage Associated with Excess H₂S. <i>Int. J. Mol. Sci.</i> 2026, <i>27</i>, 2190. [PDF]

Int J Mol Sci
Nguyen JT, Pham PP, Yan LJ.
europepmc   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Reply to Nguyen et al. Over-Intake of Plant-Derived Antioxidants, H₂S Generation, and Reductive Stress. Comment on "Manzano-Pech et al. The Chronic Elevated Consumption of <i>Hibiscus sabdariffa</i> Linnaeus Results in Kidney Damage Associated with Excess H₂S. <i>Int. J. Mol. Sci.</i> 2026, <i>27</i>, 2190". [PDF]

Int J Mol Sci
Manzano-Pech L, Soto ME, Castrejón-Tellez V, Soria-Castro E, Guarner-Lans V, Caballero-Chacón S, Martínez-Memije R, Torres-Narváez JC, El-Hafidi M, Pérez-Torres I.   +9 more
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Ursodeoxycholic acid prompts glycolytic dominance, reductive stress and epithelial-to-mesenchymal transition in ovarian cancer cells through NRF2 activation. [PDF]

Cell Death Discov
Sipos A, Kerekes É, Szeőcs D, Szarvas F, Schwarcz S, Tóth E, Ujlaki G, Mikó E, Bai P.   +8 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source