Results 71 to 80 of about 2,975,952 (304)

O-GlcNAc and the Epigenetic Regulation of Gene Expression*

Journal of Biological Chemistry, 2014
O-GlcNAcylation is an abundant nutrient-driven modification linked to cellular signaling and regulation of gene expression. Utilizing precursors derived from metabolic flux, O-GlcNAc functions as a homeostatic regulator.
B. Lewis, J. Hanover
semanticscholar   +1 more source

Transcriptional Regulation of Gene Expression in \u3cem\u3eTetrahymena thermophila\u3c/em\u3e [PDF]

, 1990
The only well-characterized study of gene expression in Tetrahymena thermophila (1) demonstrates that the temperature dependent expression of the Ser H3 gene is regulated at the level of mRNA stability.
Gorovsky, Martin A., Karrer, Kathleen M., Stargell, Laurie A.   +2 more
core   +1 more source

Spatial clustering and common regulatory elements correlate with coordinated gene expression [PDF]

, 2019
Many cellular responses to surrounding cues require temporally concerted transcriptional regulation of multiple genes. In prokaryotic cells, a single-input-module motif with one transcription factor regulating multiple target genes can generate ...
Bai, Fan, Chen, Hengyu, Li, Ruoyan, Taft, David A., Xing, Jianhua, Yao, Guang, Zhang, Jingyu   +6 more
core   +3 more sources

Animal Models of Chronic Hepatitis Delta Virus Infection Host–Virus Immunologic Interactions

Pathogens, 2015
Hepatitis delta virus (HDV) is a defective RNA virus that has an absolute requirement for a virus belonging to the hepadnaviridae family like hepatitis B virus (HBV) for its replication and formation of new virions.
Rafael Aldabe, Lester Suárez-Amarán, Carla Usai, Gloria González-Aseguinolaza   +3 more
doaj   +1 more source

Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression

Nature Genetics, 2021
Trait-associated genetic variants affect complex phenotypes primarily via regulatory mechanisms on the transcriptome. To investigate the genetics of gene expression, we performed cis- and trans-expression quantitative trait locus (eQTL) analyses using ...
U. Võsa, A. Claringbould, H. Westra, M. Bonder, Patrick Deelen, B. Zeng, H. Kirsten, A. Saha, Roman Kreuzhuber, S. Yazar, H. Brugge, R. Oelen, Dylan H. de Vries, M. V. D. van der Wijst, S. Kasela, N. Pervjakova, I. Alves, M. Favé, M. Agbessi, M. Christiansen, R. Jansen, I. Seppälä, L. Tong, A. Teumer, K. Schramm, G. Hemani, J. Verlouw, H. Yaghootkar, Reyhan Sönmez Flitman, A. Brown, V. Kukushkina, A. Kalnapenkis, S. Rüeger, E. Porcu, J. Kronberg, J. Kettunen, Bernett Lee, Futao Zhang, Ting Qi, J. A. Hernandez, W. Arindrarto, F. Beutner, Julia Dmitrieva, Mahmoud Elansary, B. Fairfax, M. Georges, B. Heijmans, A. Hewitt, M. Kähönen, Yungil Kim, J. Knight, P. Kovacs, K. Krohn, Shuang Li, M. Loeffler, U. Marigorta, Hailang Mei, Y. Momozawa, M. Müller-Nurasyid, M. Nauck, M. Nivard, B. Penninx, J. Pritchard, O. Raitakari, O. Rotzschke, E. Slagboom, C. Stehouwer, M. Stumvoll, P. Sullivan, P. ’. ’t Hoen, J. Thiery, A. Tönjes, J. van Dongen, M. van Iterson, J. Veldink, U. Völker, R. Warmerdam, C. Wijmenga, M. Swertz, A. Andiappan, G. Montgomery, S. Ripatti, M. Perola, Z. Kutalik, E. Dermitzakis, S. Bergmann, T. Frayling, J. V. van Meurs, H. Prokisch, H. Ahsan, B. Pierce, T. Lehtimäki, D. Boomsma, B. Psaty, Sina A. Gharib, P. Awadalla, L. Milani, W. Ouwehand, K. Downes, O. Stegle, A. Battle, P. Visscher, Jian Yang, M. Scholz, J. Powell, G. Gibson, T. Esko, L. Franke   +107 more
semanticscholar   +1 more source

Genetic Variation in Human Gene Regulatory Factors Uncovers Regulatory Roles in Local Adaptation and Disease [PDF]

, 2019
Differences in gene regulation have been suggested to play essential roles in the evolution of phenotypic changes. Although DNA changes in cis-regulatory elements affect only the regulation of its corresponding gene, variations in gene regulatory factors
Nowick, Katja, Perdomo-Sabogal, Álvaro
core   +1 more source

A mouse model for functional dissection of TAB1 O-GlcNAcylation [version 2; peer review: 2 approved]

Wellcome Open Research, 2020
Background: O-GlcNAcylation is a posttranslational modification associated with various physiological and pathophysiological processes including diabetes, cancer, neurodegeneration and inflammation.
Florence Authier, Villő Muha, Daan M.F. van Aalten   +2 more
doaj   +1 more source

Regulation of Gene Expression by Hypoxia [PDF]

Sleep, 1993
The present study was undertaken to determine if gene expression for tyrosine hydroxylase (TH), the rate limiting enzyme in the biosynthesis of catecholamines, is regulated in the carotid body, sympathetic ganglia and adrenal medulla by hypoxia. We found that a reduction in oxygen tension from 21% to 10% caused a substantial increase (200% at 1 hour ...
Douglas A. Bayliss, Edward E. Lawson, David E. Millhorn, Maria F. Czyzyk-Krzeska   +3 more
openaire   +3 more sources

Molecular Basis of the Function of Transcriptional Enhancers

Cells, 2020
Transcriptional enhancers are major genomic elements that control gene activity in eukaryotes. Recent studies provided deeper insight into the temporal and spatial organization of transcription in the nucleus, the role of non-coding RNAs in the process ...
Airat N. Ibragimov, Oleg V. Bylino, Yulii V. Shidlovskii   +2 more
doaj   +1 more source

Estrous behavior in dairy cows: identification of underlying mechanisms and gene functions [PDF]

, 2010
Selection in dairy cattle for a higher milk yield has coincided with declined fertility. One of the factors is reduced expression of estrous behavior. Changes in systems that regulate the estrous behavior could be manifested by altered gene expression ...
Beerda, B., Boer, H.M.T., Veerkamp, R.F., Woelders, H.   +3 more
core   +2 more sources