Results 271 to 280 of about 411,459 (300)

Optimization of transcriptional regulatory elements for constructing plasmid vectors

Gene, 2001
In studies regarding both gene therapy and gene function, transgene expression by plasmid vectors benefits from the use of transcriptional regulatory elements which permit high-level gene expression. Therefore, with respect to transgene (luciferase) expression activity both in vitro (using HeLa, HepG2, and ECV304 cells) and in vivo (mouse liver and ...
Z L, Xu, H, Mizuguchi, A, Ishii-Watabe, E, Uchida, T, Mayumi, T, Hayakawa   +5 more
openaire   +2 more sources

An Agent-Based Approach to Mine Transcriptional Regulatory Elements

2008 IEEE/WIC/ACM International Conference on Web Intelligence and Intelligent Agent Technology, 2008
The study of transcriptional regulation mechanisms is one of current research issues in post-genomic era. However, the number of the known regulatory elements is rarely limited, and the accuracy of the state-of-the-art identification methods is still far from satisfactory.
Yun Xiong, Guangyong Zheng, Qing Yang, Yangyong Zhu   +3 more
openaire   +1 more source

A Collaborative Multiagent System for Mining Transcriptional Regulatory Elements

IEEE Intelligent Systems, 2009
Identification of transcriptional regulatory elements offers a key means of insight into regulation mechanisms. However, the number of known regulatory elements is inadequate and state-of-the-art identification methods are inaccurate. Moreover, it is difficult for a biologist to select interdependent tools, and existing systems ignore overall ...
Yun Xiong, Guangyong Zheng, Qing Yang, Yangyong Zhu   +3 more
openaire   +1 more source

Sp1 binds to the adhesion molecule on glia regulatory element that functions as a positive transcription regulatory element in astrocytes

Journal of Neuroscience Research, 1993
AbstractWe analyzed cis‐acting elements regulating the expression of the gene encoding adhesion molecule on glia (AMOG) in primary cultured astrocytes from newborn rat cerebrum and cerebellum. The relative promoter activities among the series of 5‐ sequential deletion mutants are similar to those observed in B103 (rat neuroblastoma cell line) cells ...
K, Kawakami, Y, Watanabe, M, Araki, K, Nagano   +3 more
openaire   +2 more sources

Cis-Acting Transcriptional Regulatory Elements

1998
Abstract Although it is impossible to discuss the cis-acting DNA sequence elements without reference to the trans-acting factors that bind to these sequences, this chapter will primarily focus on defining the different types of positive and negative cis-acting transcriptional regulatory elements.
openaire   +1 more source

Transcription-controlling regulatory elements of the eukaryotic genome

Molecular Biology, 2015
The eukaryotic genomic regulatory elements that control transcription are considered. The review describes the functional anatomy of tissuespecific and housekeeping gene promoters, current methods to predict and to identify the enhancers, and the role insulators play in enhancer-promoter communication and maintenance of the epigenetic status of genome ...
S. V. Razin, A. A. Gavrilov, S. V. Ulyanov   +2 more
openaire   +1 more source

[Regulatory elements of the eukaryotic genome controlling transcription].

Molekuliarnaia biologiia, 2015
In this review, we discuss regulatory elements of the eukaryotic genome that control transcription. We describe the functional anatomy of tissue specific promoters and promoters of house-keeping genes; current methodologies for prediction and identification of enhancers; the role of insulators in the enhancer-promoter communication and maintenance of ...
S V, Razin, A A, Gavrilov, S V, Ulyanov
openaire   +1 more source

Transcriptional coupling of distant regulatory genes in living embryos

Nature, 2022
Michal Levo, João Raimundo, Zachary Sisco   +2 more
exaly  

Mutations in CIS-Acting Transcriptional Regulatory Elements

1998
Abstract This and subsequent chapters of Part Two will focus on human diseases that are caused by abnormal structure and/or function of the cis-acting DNA sequences or trans-acting protein factors that represent the two major components of transcriptional systems. Part Two will differ from Part One by the introduction of clinical data
openaire   +1 more source

Transcriptional regulatory network of plant cold-stress responses

Trends in Plant Science, 2022
Satoshi Kidokoro, Kazuo Shinozaki, Kazuko Yamaguchi-Shinozaki   +2 more
exaly