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Regulatory T cells and cardiovascular diseases
Chinese Medical Journal, 2023 . Inflammation is a major underlying mechanism in the progression of numerous cardiovascular diseases (CVDs). Regulatory T cells (Tregs) are typical immune regulatory cells with recognized immunosuppressive properties.
Wangling Hu +4 more
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The Therapeutic Potential of Regulatory T Cells: Challenges and Opportunities
Frontiers in Immunology, 2021 Regulatory T cells (Tregs) are an immunosuppressive subgroup of CD4+ T cells which are identified by the expression of forkhead box protein P3 (Foxp3). The modulation capacity of these immune cells holds an important role in both transplantation and the ...
Fatemeh Bayati +8 more
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Frontiers in Aging Neuroscience, 2023 BackgroundRegulatory T cells (Treg) have been identified as a key modulator of neuroinflammation in stroke. However, little is known about the association of Treg subpopulations with clinical outcome in patients with acute ischemic stroke (AIS ...
Gang Deng +9 more
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Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells
Journal for ImmunoTherapy of Cancer, 2022 Background High expression of the metabolic enzyme arginase-2 (ARG2) by cancer cells, regulatory immune cells, or cells of the tumor stroma can reduce the availability of arginine (L-Arg) in the tumor microenvironment (TME).
Marco Donia +14 more
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Frontiers in Transplantation, 2023 IntroductionHighly sensitised (HS) patients represent up to 30% of patients on the kidney transplant waiting list. When they are transplanted, they have a high risk of acute/chronic rejection and long-term allograft loss.
C. Dudreuilh +16 more
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Frontiers in Cell and Developmental Biology, 2022 B cells are the core components of humoral immunity. A mature B cell can serve in multiple capacities, including antibody production, antigen presentation, and regulatory functions.
Diaoyi Tan +17 more
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Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells
Journal of Biomedical Science, 2017 Regulatory T cells play a crucial role in the homeostasis of the immune response. In addition to CD4+Foxp3+ regulatory T cells, several subsets of Foxp3- regulatory T cells, such as T helper 3 (Th3) cells and type 1 regulatory T (Tr1) cells, have been ...
Chien-Hui Chien, Bor-Luen Chiang
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Regulatory T Cells in Autoimmune Vasculitis
Frontiers in Immunology, 2022 Blood vessels are indispensable for host survival and are protected from inappropriate inflammation by immune privilege. This protection is lost in patients with autoimmune vasculitides, a heterogeneous group of diseases causing damage to arteries ...
Ke Jin +8 more
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Regulatory T Cells in GVHD Therapy
Frontiers in Immunology, 2021 Graft versus host disease (GVHD) is a common complication and the leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Wen-wen Guo +5 more
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Characteristics of Regulatory T cells
Journal of Medical Science, 2016 Regulatory T cells (Tregs) is heterogenic subpopulation of T cells that is able to suppress function of effector cells during the immune response. Among them are natural (nTreg) and induced Treg (Tr1, Th3, CD4+CD25-).
Magdalena Frydrychowicz +6 more
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