Results 11 to 20 of about 1,894,460 (329)
Journal of Investigative Dermatology, 2006 Immunologic self-tolerance is critically dependent on the induction but also on the downregulation of immune responses. Though ignored and neglected for many years, suppressor T cells, now renamed regulatory T cells (Tregs), play an important role in the negative regulation of immune responses. Several subsets of Tregs have been described.
Agatha Schwarz +2 more
core +9 more sources
Regulatory T cells as immunotherapy [PDF]
Frontiers in Immunology, 2014 Regulatory T cells (Tregs) suppress exuberant immune system activation and promote immunologic tolerance. Because Tregs modulate both innate and adaptive immunity, the biomedical community has developed intense interest in using Tregs for immunotherapy.
Benjamin David Singer +2 more
doaj +4 more sources
Regulatory T cells induced by B cells: a novel subpopulation of regulatory T cells [PDF]
Journal of Biomedical Science, 2017 Regulatory T cells play a crucial role in the homeostasis of the immune response. In addition to CD4+Foxp3+ regulatory T cells, several subsets of Foxp3- regulatory T cells, such as T helper 3 (Th3) cells and type 1 regulatory T (Tr1) cells, have been ...
Chien-Hui Chien, Bor-Luen Chiang
doaj +4 more sources
Regulatory T cells in paracoccidioidomycosis [PDF]
Virulence, 2019 This review addresses the role of regulatory T cells (Tregs), which are essential for maintaining peripheral tolerance and controlling pathogen immunity, in the host response against Paracoccidioides brasiliensis, a primary fungal pathogen.
Vera L. G. Calich +2 more
doaj +4 more sources
MCSF drives regulatory DC development in stromal co-cultures supporting hematopoiesis [PDF]
BMC Immunology, 2018 Background Splenic stroma overlaid with hematopoietic progenitors supports in vitro hematopoiesis with production of dendritic-like cells. Co-cultures of murine lineage-depleted bone marrow over the 5G3 stromal line produce two populations of cells ...
Sawang Petvises +2 more
doaj +4 more sources
Anti-regulatory T cells are natural regulatory effector T cells [PDF]
Cell Stress, 2019 Niels Ødum
doaj +5 more sources
The Therapeutic Potential of Regulatory T Cells: Challenges and Opportunities
Frontiers in Immunology, 2021 Regulatory T cells (Tregs) are an immunosuppressive subgroup of CD4+ T cells which are identified by the expression of forkhead box protein P3 (Foxp3). The modulation capacity of these immune cells holds an important role in both transplantation and the ...
Fatemeh Bayati +8 more
doaj +1 more source
Frontiers in Aging Neuroscience, 2023 BackgroundRegulatory T cells (Treg) have been identified as a key modulator of neuroinflammation in stroke. However, little is known about the association of Treg subpopulations with clinical outcome in patients with acute ischemic stroke (AIS ...
Gang Deng +9 more
doaj +1 more source
Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells
Journal for ImmunoTherapy of Cancer, 2022 Background High expression of the metabolic enzyme arginase-2 (ARG2) by cancer cells, regulatory immune cells, or cells of the tumor stroma can reduce the availability of arginine (L-Arg) in the tumor microenvironment (TME).
Marco Donia +14 more
doaj +1 more source