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Regulatory T Cells in Asthma [PDF]
Immunity, 2009 Asthma is characterized by T helper cell 2 (Th2) type inflammation, leading to airway hyperresponsiveness and tissue remodeling. Th2 cell-driven inflammation is likely to represent an abnormal response to harmless airborne particles. These reactions are normally suppressed by regulatory T cells, which maintain airway tolerance.
Lloyd, Clare M. +1 more
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Regulatory T cells in retroviral infections. [PDF]
PLoS Pathogens, 2018 Tight regulation of immune responses is not only critical for preventing autoimmune diseases but also for preventing immunopathological damage during infections in which overactive immune responses may be more harmful for the host than the pathogen ...
Kim J Hasenkrug +2 more
doaj +1 more source
T cell equation as a conceptual model of T cell responses for maximizing the efficacy of cancer immunotherapy [PDF]
SOJ Immunol 5(1):1-5, 2017, 2015 Following antigen stimulation, the net outcomes of a T cell response are shaped by integrated signals from both positive co-stimulatory and negative regulatory molecules. Recently, the blockade of negative regulatory molecules (i.e. immune checkpoint signals) demonstrates therapeutic effects in treatment of human cancer, but only in a fraction of ...
arxiv +1 more source
Regulatory T cells for tolerance [PDF]
Human Immunology, 2018 Regulatory T cells (Tregs) are critical mediators of immune homeostasis and hold significant promise in the quest for transplantation tolerance. Progress has now reached a critical threshold as techniques for production of clinical therapies are optimised and Phase I/II clinical trials are in full swing.
Kawai, K +4 more
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Clinical & Translational Immunology, 2020 Objectives Regulatory T cells (Tregs) are a vital sub‐population of CD4+ T cells with major roles in immune tolerance and homeostasis. Given such properties, the use of regulatory T cells for immunotherapies has been extensively investigated, with a ...
Juewan Kim +8 more
doaj +1 more source
Regulatory T cells and cardiovascular diseases
Chinese Medical Journal, 2023 . Inflammation is a major underlying mechanism in the progression of numerous cardiovascular diseases (CVDs). Regulatory T cells (Tregs) are typical immune regulatory cells with recognized immunosuppressive properties.
Wangling Hu +4 more
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In vitro Regulatory T cells Differentiation From Naïve T Cells
Bio-Protocol, 2014 In the past years, a subset of regulatory T cells (Tregs) expressing CD4, CD25 and the transcription factor FoxP3 has gained considerable attention as key regulators of T-cell tolerance and homeostasis (Sakaguchi, 2004).
Tomas Dalotto +2 more
doaj +1 more source
Memory regulatory T cells in pregnancy
Frontiers in Immunology, 2023 Pregnancy requires the process of maternal immune tolerance to semi-allogeneic embryos. In contrast, an overreactive maternal immune system to embryo-specific antigens is likely to result in the rejection of embryos while damaging the invading placenta ...
Zeyang Chen +5 more
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Tissue regulatory T cells: regulatory chameleons
Nature Reviews Immunology, 2021 The FOXP3+CD4+ regulatory T (Treg) cells located in non-lymphoid tissues differ in phenotype and function from their lymphoid organ counterparts. Tissue Treg cells have distinct transcriptomes, T cell receptor repertoires and growth and survival factor dependencies that arm them to survive and operate in their home tissue. Their functions extend beyond
Andrés R. Muñoz-Rojas +3 more
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MicroRNA 10a marks regulatory T cells. [PDF]
PLoS ONE, 2012 MicroRNAs (miRNAs) are crucial for regulatory T cell (Treg) stability and function. We report that microRNA-10a (miR-10a) is expressed in Tregs but not in other T cells including individual thymocyte subsets.
Lukas T Jeker +7 more
doaj +1 more source