Results 21 to 30 of about 1,894,460 (329)
Frontiers in Transplantation, 2023 IntroductionHighly sensitised (HS) patients represent up to 30% of patients on the kidney transplant waiting list. When they are transplanted, they have a high risk of acute/chronic rejection and long-term allograft loss.
C. Dudreuilh +16 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 B cells are the core components of humoral immunity. A mature B cell can serve in multiple capacities, including antibody production, antigen presentation, and regulatory functions.
Diaoyi Tan +17 more
doaj +1 more source
Siah2 control of T-regulatory cells limits anti-tumor immunity. [PDF]
, 2020 Understanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer therapies. Here, we report that growth of BRAF-mutant melanoma cells is inhibited, up to complete rejection, in Siah2-/- mice.
Aifantis, Ioannis +15 more
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Regulatory T cells and cardiovascular diseases
Chinese Medical Journal, 2023 . Inflammation is a major underlying mechanism in the progression of numerous cardiovascular diseases (CVDs). Regulatory T cells (Tregs) are typical immune regulatory cells with recognized immunosuppressive properties.
Wangling Hu +4 more
doaj +1 more source
Current Biology, 2005 First discovered… The existence of T regulatory cells was first suggested by several animal models in the 1970s. Organ-specific autoimmunity was found to be induced in specific strains of mice that had been thymectomized 3 days after birth but not after thymectomy at 0 or 7 days.
openaire +3 more sources
Tissue regulatory T cells [PDF]
Immunology, 2020 SummaryFoxp3+ CD4+ regulatory T cells (Tregs) are an immune cell lineage endowed with immunosuppressive functionality in a wide array of contexts, including both anti‐pathogenic and anti‐self responses. In the past decades, our understanding of the functional diversity of circulating or lymphoid Tregs has grown exponentially.
Inchul Cho +3 more
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Regulatory T Cells in Asthma [PDF]
Immunity, 2009 Asthma is characterized by T helper cell 2 (Th2) type inflammation, leading to airway hyperresponsiveness and tissue remodeling. Th2 cell-driven inflammation is likely to represent an abnormal response to harmless airborne particles. These reactions are normally suppressed by regulatory T cells, which maintain airway tolerance.
Lloyd, Clare M. +1 more
openaire +4 more sources
Regulatory T Cells in GVHD Therapy
Frontiers in Immunology, 2021 Graft versus host disease (GVHD) is a common complication and the leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Wen-wen Guo +5 more
doaj +1 more source
FOXP3 interacts with hnRNPF to modulate pre-mRNA alternative splicing [PDF]
, 2018 FOXP3 promotes the development and function of regulatory T cells mainly through regulating the transcription of target genes. RNA alternative splicing has been implicated in a wide range of physiological and pathophysiological processes.
Du, Jianguang +3 more
core +1 more source
Differential Responses of Human Regulatory T Cells (Treg) and Effector T Cells to Rapamycin [PDF]
, 2009 Background: The immunosuppressive drug rapamycin (RAPA) promotes the expansion of CD4+ CD25highFoxp3+ regulatory\ud T cells via mechanisms that remain unknown.
Derya Unutmaz +5 more
core +5 more sources