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Emerging strategies to target metastasis and therapy resistance in melanoma

Molecular Oncology, EarlyView.
Emerging studies propose new approaches to interfere with melanoma progression. In recognition of melanoma awareness month, at Molecular Oncology, we highlight recently published research articles, focusing on novel therapeutic targets driving metastatic spread and outlining different strategies to overcome resistance to BRAF inhibitors and anti‐PD‐1 ...
Amel Aziba
wiley   +1 more source

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Relative biological effectiveness (RBE) values for proton beam therapy

International Journal of Radiation Oncology Biology Physics, 2002
Clinical proton beam therapy has been based on the use of a generic relative biological effectiveness (RBE) of 1.0 or 1.1, since the available evidence has been interpreted as indicating that the magnitude of RBE variation with treatment parameters is small relative to our abilities to determine RBEs.
Harald Paganetti, Andrzej Niemierko
exaly   +3 more sources

Calculation of relative biological effectiveness for proton beams using biological weighting functions

International Journal of Radiation Oncology Biology Physics, 1997
The microdosimetric weighting function approach is used widely for beam comparison studies. The suitability of this model to predict the relative biological effectiveness (RBE) of therapeutic proton beams was studied. The RBE(alpha) (i.e., linear approximation) dependence on the type of biological end point, initial proton energy, energy spread of the ...
Harald Paganetti, Pawel Olko, Michael P R Waligorski   +2 more
exaly   +3 more sources

Relative Biological Effectiveness of 592-MeV Protons on Mice

Nature, 1965
Baarli, J, Bonet, maury P
exaly   +3 more sources

Tritium Radiobiology and Relative Biological Effectiveness

Health Physics, 1993
During the past decade, a large number of radiobiological studies have become available for tritium--many of them focusing on the relative biological effectiveness of tritium beta rays. These and previous studies indicate that tritium in body water produces the same spectrum of radiogenic effects (e.g., cancer, genetic effects, developmental ...
T, Straume, A L, Carsten
openaire   +2 more sources

Relative Biological Effectiveness of 17 MeV Electrons

The British Journal of Radiology, 1953
An electron beam with energy adjustable up to 22 MeV has been developed with sufficient intensity and control for biological experimentation and therapeutic applications (Laughlin, Ovadia, Beattle, Henderson, Harvey and Haas, in press). Various experiments have been in progress to evaluate the biological effects of such electrons on animals and human ...
M K, AUSTIN, J S, LAUGHLIN, H, QUASTLER
openaire   +2 more sources

Relative biological effectiveness of ^99m Tc radiopharmaceuticals

Medical Physics, 1994
The radiotoxicity of three 99mTc-labeled compounds is investigated using spermatogenesis in mouse testis as the experimental model, and spermatogonial cell survival as the biological end point. The radiopharmaceuticals studied are pertechnetate (99mTcO4-), pyrophosphate (99mTc-PYP), and hydroxyethylene diphosphate (99mTc-HDP).
V R, Narra, K S, Sastry, S M, Goddu, R W, Howell, S E, Strand, D V, Rao   +5 more
openaire   +2 more sources

Relative Biological Effectiveness of Internal Emitters

Radiology, 1956
Permissible levels of exposure to radioactive materials have been based in large part upon two sets of comparisons. In the first, the radiotoxic hazards of the various isotopes are evaluated relative to radium in experimental animals. In the second, extrapolations are made to man through radium as the common link, since the latent effects of that ...
openaire   +2 more sources

Oxygen Effect, Relative Biological Effectiveness, and Linear Energy Transfer

2014
Oxygen is one of the most effective dose-modifying agents. Oxygen causes “fixation” of radiation-induced DNA damage. The oxygen enhancement ratio (OER) is equal to the ratio of doses of radiation (hypoxic over oxic) required to achieve the same biological effect.
David S. Chang, Foster D. Lasley, Indra J. Das, Marc S. Mendonca, Joseph R. Dynlacht   +4 more
openaire   +1 more source

Toxicity and Relative Biological Effectiveness of Alpha Emitting Radioimmunoconjugates

Current Radiopharmaceuticalse, 2011
Radioimmunotherapy based on α-particle emitters has excellent properties as a treatment against micrometastatic and disseminated cancers because of the short path length (50 - 80 μm) and high linear energy transfer (∼ 100 keV/ μm). Alpha-particles produce clustered DNA double-strand breaks and highly reactive hydroxyl radicals when hitting biological ...
Jostein, Dahle, Nasir, Abbas, Øyvind S, Bruland, Roy H, Larsen   +3 more
openaire   +2 more sources