Postnatal development of the relaxin-3 innervation of the rat medial septum. [PDF]
Front Neurosci, 2023 IntroductionThe septal area provides a rich innervation to the hippocampus regulating hippocampal excitability to different behavioral states and modulating theta rhythmogenesis.
Ros-Bernal F +6 more
europepmc +2 more sources
Expression of relaxin-3 and its receptors in the hypothalamic-pituitary-ovary axis in layers and broiler breeders. [PDF]
Poult SciLayers can regulate their feed intake and maintain well-organized ovaries. Conversely, broiler breeders are prone to overeating, leading to disorganized ovaries.
Boukherroub K +5 more
europepmc +2 more sources
Sex hormones in the nucleus incertus: a novel perspective on sex/gender differences in memory and mood dysfunction in Alzheimer's disease. [PDF]
Front Aging NeurosciAbout 60% of the individuals living with Alzheimer’s disease (AD) in the United States are women. Increasing evidence points to a role for sex hormones, especially estrogen, in making women more vulnerable to AD than men.
de Ávila C +3 more
europepmc +2 more sources
Relaxin-2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat. [PDF]
FASEB JCardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Vázquez-Abuín X +11 more
europepmc +2 more sources
Silencing relaxin-3 in nucleus incertus of adult rodents: a viral vector-based approach to investigate neuropeptide function. [PDF]
PLoS ONE, 2012 Relaxin-3, the most recently identified member of the relaxin peptide family, is produced by GABAergic projection neurons in the nucleus incertus (NI), in the pontine periventricular gray.
Gabrielle E Callander +6 more
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Estrogen receptor alpha XbaI polymorphism is associated with higher relaxin-3 levels in women with metabolic syndrome [PDF]
Records of Pharmaceutical & Biomedical Sciences, 2017 Relaxin-3 is known to play a role in appetite regulation, increasing food intake and body weight. This study aimed to assess the relation of relaxin-3 with ERS1 XbaI and PvuII polymorphisms.
Dina Abo-Elmatty +3 more
doaj +1 more source
In vitro pharmacological characterization of RXFP3 allosterism: an example of probe dependency. [PDF]
PLoS ONE, 2012 Recent findings suggest that the relaxin-3 neural network may represent a new ascending arousal pathway able to modulate a range of neural circuits including those affecting circadian rhythm and sleep/wake states, spatial and emotional memory, motivation
Lily Alvarez-Jaimes +7 more
doaj +1 more source
Scientific Reports, 2022 Relaxin-2 exerts many favourable cardiovascular effects in pathological circumstances such as atrial fibrillation (AF) and heart failure, but the mechanisms underlying its actions are not completely understood. Since inflammation and fibrosis are pivotal
Alana Aragón-Herrera +14 more
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Evolution of the relaxin-like peptide family
BMC Evolutionary Biology, 2005 Background The relaxin-like peptide family belongs in the insulin superfamily and consists of 7 peptides of high structural but low sequence similarity; relaxin-1, 2 and 3, and the insulin-like (INSL) peptides, INSL3, INSL4, INSL5 and INSL6.
Tregear Geoffrey W +3 more
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Frontiers in Pharmacology, 2020 Introduction: P2X7R excitation-interrelated NLRP3 inflammasome activation induced by high glucose contributes to the pathogenesis of diabetic retinopathy (DR).
Kelaier Yang +9 more
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