Results 21 to 30 of about 7,173 (124)

High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist

Molecules, 2021
Relaxin/insulin-like family peptide receptor 3 (RXFP3) belongs to class A G protein-coupled receptor family. RXFP3 and its endogenous ligand relaxin-3 are mainly expressed in the brain with important roles in the regulation of appetite, energy metabolism,
Guangyao Lin, Yang Feng, Xiaoqing Cai, Caihong Zhou, Lijun Shao, Yan Chen, Linhai Chen, Qing Liu, Qingtong Zhou, Ross A.D. Bathgate, Dehua Yang, Ming-Wei Wang   +11 more
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Relaxin protects astrocytes from hypoxia in vitro.

PLoS ONE, 2014
The peptide relaxin has recently been shown to protect brain tissues from the detrimental effects of ischemia. To date, the mechanisms for this remain unclear. In order to investigate the neuroprotective mechanisms by which relaxin may protect the brain,
Jordan M Willcox, Alastair J S Summerlee
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Comparative distribution of relaxin-3 inputs and calcium-binding protein-positive neurons in rat amygdala

Frontiers in Neuroanatomy, 2016
The neural circuits involved in mediating complex behaviors are being rapidly elucidated using various newly developed and powerful anatomical and molecular techniques, providing insights into the neural basis for anxiety disorders, depression, addiction,
Fabio N Santos, Celia W Pereira, Ana M Sanchez-perez, Marcos eOtero, Sherie K Ma, Andrew L Gundlach, Andrew L Gundlach, Francisco E Olucha-Bordonau   +7 more
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RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a Gαi2-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway

Frontiers in Physiology, 2018
Background: Relaxins are small peptide hormones, which are novel candidate molecules that play important roles in cardiometablic syndrome. Relaxins are structurally related to the insulin hormone superfamily, which provide vasodilatory effects by ...
Xiaoming Lian, Sandra Beer-Hammer, Gabriele M. König, Evi Kostenis, Bernd Nürnberg, Maik Gollasch, Maik Gollasch   +6 more
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Greater presence of receptors for relaxin in the ligamentum teres of female infants who undergo open reduction for developmental dysplasia of the hip

Journal of Orthopaedic Surgery and Research, 2021
Background While many factors involved in the etiology of developmental dysplasia of the hip (DDH), one of which is the hormone relaxin. Relaxin concentrations in patients with DDH may lead to pathodynamic changes during hip development by altering the ...
Semih Ayanoğlu, Haluk Çabuk, Fatmagül Kuşku Çabuk, Kubilay Beng, Timur Yildirim, Süheyla Uyar Bozkurt   +5 more
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Relaxin-3-deficient mice showed slight alteration in anxiety-related behavior

Frontiers in Behavioral Neuroscience, 2011
Relaxin-3 is a neuropeptide belonging to the relaxin/insulin superfamily. Studies using rodents have revealed that relaxin-3 is predominantly expressed in neurons in the nucleus incertus of the pons, the axons of which project to forebrain regions ...
Yoshihisa eWatanabe, Atsushi eTsujimura, Keizo eTakao, Kazunori eNishi, Yasuaki eIto, Yoshitaka eYasuhara, Yasuhito eNakatomi, Chihiro eYokoyama, Kenji eFukui, Tsuyoshi eMiyakawa, Masaki eTanaka   +10 more
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Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3

Frontiers in Endocrinology, 2013
Relaxin-3 is a highly conserved neuropeptide in vertebrate species and binds to the Class A G protein-coupled receptor RXFP3. Relaxin-3 is involved in a wide range of behaviours, including feeding, stress responses, arousal and cognitive processes and ...
Ross eBathgate, Ross eBathgate, Maria eOh, Maria eOh, Jason eLing, Jason eLing, Quentin eKaas, Akhter eHossain, Akhter eHossain, Paul eGooley, Johan eRosengren   +10 more
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Relaxin Inhibits Ventricular Arrhythmia and Asystole in Rats With Pulmonary Arterial Hypertension

Frontiers in Cardiovascular Medicine, 2021
Pulmonary arterial hypertension (PAH) leads to right ventricular cardiomyopathy and cardiac dysfunctions where in the clinical setting, cardiac arrest is the likely cause of death, in ~70% of PAH patients.
Brian Martin, Brian Martin, Brian Martin, Rebecca R. Vanderpool, Rebecca R. Vanderpool, Rebecca R. Vanderpool, Brian L. Henry, Brian L. Henry, Joshua B. Palma, Joshua B. Palma, Beth Gabris, Beth Gabris, Yen-Chun Lai, Yen-Chun Lai, Jian Hu, Jian Hu, Stevan P. Tofovic, Stevan P. Tofovic, Stevan P. Tofovic, Rajiv P. Reddy, Rajiv P. Reddy, Ana L. Mora, Ana L. Mora, Ana L. Mora, Mark T. Gladwin, Mark T. Gladwin, Mark T. Gladwin, Guillermo Romero, Guy Salama, Guy Salama, Guy Salama, Guy Salama   +31 more
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Relaxin does not improve Angiotensin II-induced target-organ damage.

PLoS ONE, 2014
Relaxin is a corpus-luteum produced protein hormone with vasodilatatory, anti-fibrotic, and angiogenic properties that are opposite to angiotensin (Ang) II. We investigated whether or not relaxin ameliorates Ang II-induced target-organ damage.
Nadine Haase, Julianna Rugor, Lukasz Przybyl, Fatimunnisa Qadri, Dominik N Müller, Ralf Dechend   +5 more
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H3 Relaxin Protects Against Myocardial Injury in Experimental Diabetic Cardiomyopathy by Inhibiting Myocardial Apoptosis, Fibrosis and Inflammation

Cellular Physiology and Biochemistry, 2017
Background/Aims: Apoptosis, fibrosis and NLRP3 inflammasome activation are involved in the development of diabetic cardiomyopathy (DCM). Human recombinant relaxin-3 (H3 relaxin) is a novel bioactive peptide that inhibits cardiac injury; however, whether ...
Xiaohui Zhang, Liya Pan, Kelaier Yang, Yu Fu, Yue Liu, Jinyu Chi, Xin Zhang, Siting Hong, Xiao Ma, Xinhua Yin   +9 more
doaj   +1 more source