Results 31 to 40 of about 7,173 (124)

Relaxin-3/RXFP3 signaling and neuroendocrine function – A perspective on extrinsic hypothalamic control

Frontiers in Endocrinology, 2013
Complex neural circuits within the hypothalamus that govern essential autonomic processes and associated behaviors signal using amino acid and monoamine transmitters and a variety of neuropeptide (hormone) modulators, often via G-protein coupled ...
Despina E Ganella, Sherie eMa, Andrew L Gundlach   +2 more
doaj   +1 more source

Functional Neuroanatomy of the Rat Nucleus Incertus–Medial Septum Tract: Implications for the Cell-Specific Control of the Septohippocampal Pathway

Frontiers in Cellular Neuroscience, 2022
The medial septum (MS) is critically involved in theta rhythmogenesis and control of the hippocampal network, with which it is reciprocally connected. MS activity is influenced by brainstem structures, including the stress-sensitive, nucleus incertus (NI)
Agata Szlaga, Patryk Sambak, Aleksandra Trenk, Anna Gugula, Caitlin E. Singleton, Gniewosz Drwiega, Tomasz Blasiak, Sherie Ma, Andrew L. Gundlach, Andrew L. Gundlach, Andrew L. Gundlach, Anna Blasiak   +11 more
doaj   +1 more source

Differential Level of RXFP3 Expression in Dopaminergic Neurons Within the Arcuate Nucleus, Dorsomedial Hypothalamus and Ventral Tegmental Area of RXFP3-Cre/tdTomato Mice

Frontiers in Neuroscience, 2021
RXFP3 (relaxin-family peptide 3 receptor) is the cognate G-protein-coupled receptor for the neuropeptide, relaxin-3. RXFP3 is expressed widely throughout the brain, including the hypothalamus, where it has been shown to modulate feeding behavior and ...
Lara M. Voglsanger, Justin Read, Sarah S. Ch’ng, Cary Zhang, Izel M. Eraslan, Laura Gray, Leni R. Rivera, Lee D. Hamilton, Richard Williams, Andrew L. Gundlach, Craig M. Smith   +10 more
doaj   +1 more source

C-terminus of the B-chain of relaxin-3 is important for receptor activity. [PDF]

PLoS ONE, 2013
Human relaxin-3 is a neuropeptide that is structurally similar to human insulin with two chains (A and B) connected by three disulfide bonds. It is expressed primarily in the brain and has modulatory roles in stress and anxiety, feeding and metabolism ...
Fazel Shabanpoor, Ross A D Bathgate, John D Wade, Mohammed Akhter Hossain   +3 more
doaj   +1 more source

Integrative Multi‐Omics Analysis Reveals a Mitochondrial–Immune Axis Associated With Neoadjuvant Chemotherapy Response in High‐Grade Serous Ovarian Cancer

Advanced Science, EarlyView.
Integrative multi‐omics analysis delineates a mitochondrial–immune axis governing neoadjuvant chemotherapy response in high‐grade serous ovarian cancer. Immune‐active tumors exhibit enhanced B‐cell infiltration and favorable sensitivity, whereas metabolically rewired tumors display oxidative phosphorylation dependency and resistance.
Wei Jiang, Yi Wang, Xiaohang Lu, Qianlan Yao, Libing Xiang, Xu Cai, Xiaoyu Tu, Shaoxian Tang, Ying Xu, Yufan Cheng, Liming Shen, Huijuan Yang   +11 more
wiley   +1 more source

In vitro effects of relaxin on gene expression in porcine cumulus-oocyte complexes and developing embryos

Reproductive Biology and Endocrinology, 2011
Background Relaxin hormone peptide is found in porcine follicular and utero-tubal fluids, but its possible actions during early embryo development are still undetermined.
Willard Scott T, Greene Jonathan M, Feugang Jean M, Ryan Peter L   +3 more
doaj   +1 more source

Pelvic morphology and body size in relation to the preauricular sulcus: Evidence from medieval to modern Iberia

The Anatomical Record, EarlyView.
Abstract The preauricular sulcus has long been debated as a pelvic feature variably attributed to obstetric stress, ligamentous traction, and broader biomechanical processes. To clarify its determinants, we analyzed 409 adult individuals from three archeological and one early modern skeletal collection from the Iberian Peninsula, integrating graded ...
Rebeca García‐González, Julia Muñoz‐Guarinos, Nico Cirotto, Sonia Díaz‐Navarro, Laura Rodríguez, José Miguel Carretero   +5 more
wiley   +1 more source

Septal GABA and Glutamate Neurons Express RXFP3 mRNA and Depletion of Septal RXFP3 Impaired Spatial Search Strategy and Long-Term Reference Memory in Adult Mice

Frontiers in Neuroanatomy, 2019
Relaxin-3 is a highly conserved neuropeptide abundantly expressed in neurons of the nucleus incertus (NI), which project to nodes of the septohippocampal system (SHS) including the medial septum/diagonal band of Broca (MS/DB) and dorsal hippocampus, as ...
Mouna Haidar, Mouna Haidar, Kimberly Tin, Kimberly Tin, Cary Zhang, Mohsen Nategh, João Covita, João Covita, Alexander D. Wykes, Alexander D. Wykes, Jake Rogers, Jake Rogers, Andrew L. Gundlach, Andrew L. Gundlach, Andrew L. Gundlach   +14 more
doaj   +1 more source

Relaxin-3 receptor (RXFP3) signalling mediates stress-related alcohol preference in mice. [PDF]

PLoS ONE, 2015
Stressful life events are causally linked with alcohol use disorders (AUDs), providing support for a hypothesis that alcohol consumption is aimed at stress reduction. We have previously shown that expression of relaxin-3 mRNA in rat brain correlates with
Andrew W Walker, Craig M Smith, Berenice E Chua, Elena V Krstew, Cary Zhang, Andrew L Gundlach, Andrew J Lawrence   +6 more
doaj   +1 more source

The 9+ month marathon: How pregnancy may have shaped human endurance capacities

The Anatomical Record, EarlyView.
Abstract Anthropology has long considered the evolution of our uniquely human endurance capacities to be the result of selection upon anatomical and physiological features imposed by the demands of thermoregulation and resource acquisition, particularly during the demands of persistence hunting. Research has focused on the anatomical changes present in
Cara Ocobock
wiley   +1 more source