Results 171 to 180 of about 17,448,568 (253)

Klotho Deficiency Impairs Distal Potassium Homeostasis Through mTORC1‐Dependent Suppression of ROMK

open access: yesActa Physiologica, Volume 242, Issue 11, November 2026.
ABSTRACT Aim Hyperkalemia is prevalent in the elderly, and underlying molecular mechanisms remain incompletely understood. We hypothesized that Klotho deficiency, a feature of aging, impairs renal potassium homeostasis and contributes to hyperkalemia. Methods Klotho heterozygous knockout (KLhet) mice, characterized by reduced Klotho levels, were used ...
Wakako Kawarazaki   +6 more
wiley   +1 more source

Renin-angiotensin-aldosterone system inhibition exacerbates anemia in sickle cell disease.

open access: yesBlood
Eskandari N   +11 more
europepmc   +1 more source

Vitamin D: Physiology, Pharmacology and Clinical Evidence for Supplementation—A Narrative Review

open access: yesBasic &Clinical Pharmacology &Toxicology, Volume 139, Issue 5, November 2026.
ABSTRACT Vitamin D is a nutrient and prohormone obtained from diet and supplements and synthesized in the skin. It is essential for calcium and phosphate homeostasis and skeletal health and influences multiple extra‐skeletal processes, yet deficiency remains common worldwide.
Jyrki K. Virtanen
wiley   +1 more source

A Ten Year Overview of Adrenal Vein Sampling in Croatia: Insights and Outcomes

open access: yesClinical Endocrinology, Volume 105, Issue 5, Page 533-539, November 2026.
ABSTRACT Background Adrenal vein sampling (AVS) is the gold standard for subtype differentiation in primary aldosteronism (PA), yet it remains technically demanding and resource intensive. However, data on long‐term performance, learning curves, and concordance with imaging in real‐world clinical practice are limited.
Karin Zibar Tomsic   +4 more
wiley   +1 more source

Cardiovascular reserve as an integrative physiological construct: Current evidence, emerging technologies and future directions

open access: yesClinical Physiology and Functional Imaging, Volume 46, Issue 6, November 2026.
Abstract Cardiovascular reserve represents the integrated physiological capacity of the cardiovascular system to maintain tissue perfusion during increasing physiological stress. Although reserve has long been recognized conceptually, its direct assessment remains challenging.
Uri Gabbay   +2 more
wiley   +1 more source

Impact of continuing renin-angiotensin-aldosterone system inhibitors before surgery on intraoperative hypotensive events: a secondary analysis of the STOP-or-NOT Trial. [PDF]

open access: yesBr J Anaesth
Pirracchio R   +9 more
europepmc   +1 more source

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