SGLT2i in heart failure: Cardiorenal mechanisms, clinical evidence and translational perspectives
SGLT2 inhibitors improve heart failure outcomes through integrated cardiorenal mechanisms. In the kidney, they reduce glucose and sodium reabsorption, promoting natriuresis, osmotic diuresis and renal protection. In the heart, they enhance myocardial energetics, reduce inflammation, oxidative stress, fibrosis and adverse remodelling, resulting in fewer
Jelica Grujic‐Milanovic +4 more
wiley +1 more source
Is long-term disruption of the renin-angiotensin-aldosterone system associated with long COVID? A retrospective cohort study among healthcare workers. [PDF]
Lange-Tal T +7 more
europepmc +1 more source
This graphical abstract illustrates the complete translational pipeline of Terminalia arjuna in modern phytomedicine and functional food development. It is rich in key bioactive compounds like arjunolic acid, arjungenin, flavonoids, and tannins which serve as the foundation for the plant's versatile medicinal uses and offers broad therapeutic benefits ...
Ishani Banerjee +5 more
wiley +1 more source
Chronic Prescription of Renin-Angiotensin-Aldosterone System Inhibitors and Hospital Outcomes in Patients with Hypertension and COVID-19. [PDF]
De Oliveira KA +12 more
europepmc +1 more source
Molecular and Cellular Underpinnings of Primary Hypertension: An Integrative Mechanistic Framework
ABSTRACT Hypertension is a highly prevalent clinical condition and a major contributor to global cardiovascular morbidity and mortality. Despite extensive research, its complex and multifaceted pathogenesis is yet to be fully elucidated. This paper explores the updated understanding of primary hypertension as a systemic disorder rather than an isolated
Dima Nasrallah +5 more
wiley +1 more source
Correlation Between Activity Level of Renin-Angiotensin-Aldosterone System and Perfusion Index in Children with Postural Tachycardia Syndrome. [PDF]
Zhang F, Pan J, Lin Z, Niu M.
europepmc +1 more source
From 1999 to 2020, 51 756 U.S. deaths documented both sudden cardiac death and diabetes mellitus, with population‐level burden rising significantly (APC +0.46%). Disparities were greatest among men, Black populations, rural residents, and Southern states, with a sharp mortality surge in 2020 coinciding with the COVID‐19 pandemic.
Taha Mehmood +14 more
wiley +1 more source
Renin-Angiotensin-Aldosterone System Profiling in Horses Before and After Exercise. [PDF]
Holbrook T +6 more
europepmc +1 more source
Radiotherapy‐Induced Side Effects: Epidemiology, Pathogenesis, Prevention and Treatments
Radiotherapy for malignancies frequently injures the organs’ systems through oxidative stress, fibrosis, inflammation, and vascular damage. This review systematically maps the epidemiology, pathogenesis, and emerging therapies to propose a mechanism‑network‑targeted framework for integrated, personalized care in radiation oncology.
Xiaowen Ma +9 more
wiley +1 more source
Phenylephrine Vs. Norepinephrine on the Renin-Angiotensin-Aldosterone System and Postoperative Complications in Acute Abdomen Emergency Surgery: A Randomized Controlled Trial. [PDF]
Chen J +14 more
europepmc +1 more source

