Results 11 to 20 of about 22,692,331 (249)

Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic

Nature Reviews Nephrology, 2020
The current COVID-19 pandemic is associated with unprecedented morbidity and mortality. Early reports suggested an association between disease severity and hypertension but did not account for sources of confounding. However, the responsible virus — SARS-
A. South, L. Tomlinson, Daniel L. Edmonston, S. Hiremath, M. Sparks   +4 more
semanticscholar   +1 more source

Hypertension, the renin–angiotensin system, and the risk of lower respiratory tract infections and lung injury: implications for COVID-19

Cardiovascular Research, 2020
Systemic arterial hypertension (referred to as hypertension herein) is a major risk factor of mortality worldwide, and its importance is further emphasized in the context of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection
R. Kreutz, E. Algharably, M. Azizi, P. Dobrowolski, T. Guzik, A. Januszewicz, A. Persu, A. Prejbisz, T. Riemer, Ji-Guang Wang, M. Burnier   +10 more
semanticscholar   +1 more source

Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System? A Call for Epidemiologic Investigations

Clinical Infectious Diseases, 2020
Mortality from coronavirus disease 2019 (COVID-19) is strongly associated with cardiovascular disease, diabetes, and hypertension. These disorders share underlying pathophysiology related to the renin-angiotensin system (RAS) that may be clinically ...
T. Hanff, M. O. Harhay, T. Brown, Jordana B. Cohen, Amir M. Mohareb   +4 more
semanticscholar   +1 more source

COVID-19, Renin-Angiotensin System and Endothelial Dysfunction

Cells, 2020
The newly emergent novel coronavirus disease 2019 (COVID-19) outbreak, which is caused by SARS-CoV-2 virus, has posed a serious threat to global public health and caused worldwide social and economic breakdown.
Razie Amraei, N. Rahimi
semanticscholar   +1 more source

The ACE2/Angiotensin-(1–7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1–7)

Physiological Reviews, 2017
The renin-angiotensin system (RAS) is a key player in the control of the cardiovascular system and hydroelectrolyte balance, with an influence on organs and functions throughout the body.
R. Santos, W. Sampaio, A. Alzamora, D. Motta-Santos, N. Alenina, M. Bader, M. Campagnole-Santos   +6 more
semanticscholar   +1 more source

Renin-Angiotensin System Blockers and the COVID-19 Pandemic

HYPERTENSION, 2020
During the spread of the severe acute respiratory syndrome coronavirus-2, some reports of data still emerging and in need of full analysis indicate that certain groups of patients are at risk of COVID-19.
A. Danser, M. Epstein, D. Batlle
semanticscholar   +1 more source

Counter-regulatory renin–angiotensin system in cardiovascular disease

Nature Reviews Cardiology, 2019
The renin–angiotensin system is an important component of the cardiovascular system. Mounting evidence suggests that the metabolic products of angiotensin I and II — initially thought to be biologically inactive — have key roles in cardiovascular ...
María Paz Ocaranza, Jaime A Riquelme, Lorena García, J. Jalil, M. Chiong, R. Santos, S. Lavandero   +6 more
semanticscholar   +1 more source

Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19

New England Journal of Medicine, 2020
Background There is concern about the potential of an increased risk related to medications that act on the renin–angiotensin–aldosterone system in patients exposed to coronavirus disease 2019 (Covid-19), because the viral receptor is angiotensin ...
H. Reynolds, S. Adhikari, C. Pulgarin, A. Troxel, Eduardo Iturrate, Stephen B. Johnson, A. Hausvater, J. Newman, J. Berger, S. Bangalore, S. Katz, G. Fishman, Dennis Kunichoff, Yu Chen, G. Ogedegbe, J. Hochman   +15 more
semanticscholar   +1 more source

Downregulation of ACE2 induces overstimulation of the renin–angiotensin system in COVID-19: should we block the renin–angiotensin system?

Hypertension Research, 2020
Severe acute respiratory syndrome coronavirus 2 is the cause of the ongoing coronavirus disease-19 (COVID-19) pandemic. Mortality is mainly due to acute respiratory distress syndrome (ARDS) [1].
F. Silhol, G. Sarlon, J. Deharo, B. Vaïsse   +3 more
semanticscholar   +1 more source

Renin–Angiotensin–Aldosterone System Blockers and the Risk of Covid-19

New England Journal of Medicine, 2020
Background A potential association between the use of angiotensin-receptor blockers (ARBs) and angiotensin-converting–enzyme (ACE) inhibitors and the risk of coronavirus disease 2019 (Covid-19) has not been well studied.
G. Mancia, F. Rea, M. Ludergnani, G. Apolone, G. Corrao   +4 more
semanticscholar   +1 more source