Results 11 to 20 of about 172,199 (241)

New Approaches to Blockade of the Renin–Angiotensin–Aldosterone System: Characteristics and Usefulness of the Direct Renin Inhibitor Aliskiren

Journal of Pharmacological Sciences, 2010
Since renin inhibition interferes with the first and rate-limiting steps in the renin–angiotensin system, the renin step is a very attractive target for lowering blood pressure and minimizing target-organ damage.
Atsuhiro Ichihara, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Kanako Bokuda, Hiroshi Itoh   +6 more
doaj   +1 more source

The renin–angiotensin system: a possible new target for depression

BMC Medicine, 2017
Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin–angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways related to neurodevelopment ...
João Vian, Círia Pereira, Victor Chavarria, Cristiano Köhler, Brendon Stubbs, João Quevedo, Sung-Wan Kim, André F. Carvalho, Michael Berk, Brisa S. Fernandes   +9 more
doaj   +1 more source

Immunohistochemical expression of intrarenal renin angiotensin system components in response to tempol in rats fed a high salt diet [PDF]

, 2017
AIM:To determine the effect of tempol in normal rats fed high salt on arterial pressure and the balance between antagonist components of the renal renin-angiotensin system.METHODS:Sprague-Dawley rats were fed with 8% NaCl high-salt (HS) or 0.4% NaCl ...
Cao, Gabriel Fernando, Choi, Marcelo Roberto, Della Penna, Silvana Lorena, Fernandez, Belisario Enrique, Gorzalczany, Susana Beatriz, Kouyoumdzian, Nicolás Martín, Roson, Maria Ines, Toblli, Jorge Eduardo   +7 more
core   +1 more source

Increased circulating ANG II and TNF-α represents important risk factors in obese Saudi adults with hypertension irrespective of diabetic status and BMI [PDF]

, 2012
Central adiposity is a significant determinant of obesity-related hypertension risk, which may arise due to the pathogenic inflammatory nature of the abdominal fat depot.
A Berrington de Gonzalez, A Harte, A Taube, AG Bertoni, Aimin Xu, Alison L. Harte, Amany O. Mohamed, AV Chobanian, B Chamarthi, BL Goodwin, BM Celoria, BM Cheung, C Asferg, C Asferg, C Savoia, D Gurantz, D Kalra, D Ma, ES Androulakis, F Galletti, F Galletti, G Mancia, H Itani, H Zhang, Hossam M. Draz, J Feber, J Liu, JD Fowler, JE Hall, JM do Carmo, JV Patel, K Ohashi, KF Adams, Khalid M. Alkharfy, L Alhyas, LE Bautista, Lotfi S. Bindahman, M Adamczak, M Carlyle, M Hernandez-Presa, M Pruijm, M Tohidi, M Vlasova, MA Al-Homrany, Majed S. Alokail, MY Baden, N Al-Daghri, Nasser M. Al-Daghri, NM Al-Daghri, NS Kalupahana, Omar S. Al-Attas, Philip G. McTernan, R Fogari, R Summer, RT Sabo, S Sriramula, S Yasue, Sobhy Yakout, T Wago, TA Kotchen, Tahia H. Saleem, X Gao, Y Deng, Y Takeshita   +63 more
core   +5 more sources

Cardio and neuro protection by renin angiotensin aldosterone system-focus inhibition angiotensin converting enzyme: A systematic review [PDF]

BIO Web of Conferences
One of the incidences of cardiovascular disease is stroke, which is a disease that occurs due to impaired brain function caused by damage to cerebral blood circulation.
Capritasari Rafiastiana, Akrom, Setianto Arif Budi   +2 more
doaj   +1 more source

Influence of Captopril Treatment of Plasma Renin Activity � Mathematical Model

Notulae Scientia Biologicae, 2010
A model of the dynamics of plasma renin activity under the influence of various doses of captopril is formulated. The influence of captopril on renin angiotensin system is different from the effects of the other studied drugs nifedipine and nicardipine.
Kaloyan Bonchev YANKOV, Anna Naidenova TOLEKOVA   +1 more
doaj   +3 more sources

The Renin-Angiotensin System Modulates Inflammatory Processes in Atherosclerosis: Evidence from Basic Research and Clinical Studies

Mediators of Inflammation, 2009
Recent evidence shows that the renin-angiotensin system is a crucial player in atherosclerotic processes. The regulation of arterial blood pressure was considered from its first description of the main mechanism involved.
Fabrizio Montecucco, Aldo Pende, François Mach   +2 more
doaj   +1 more source

Pathological Role of Angiotensin II in Severe COVID-19

TH Open, 2020
The activated renin–angiotensin system induces a prothrombotic state resulting from the imbalance between coagulation and fibrinolysis. Angiotensin II is the central effector molecule of the activated renin–angiotensin system and is degraded by the ...
Wolfgang Miesbach
doaj   +1 more source

Non-employment and low educational level as risk factors for inequitable treatment and mortality in heart failure: a population-based cohort study of register data

BMC Public Health, 2021
Background The risk of heart failure is disproportionately high among the socioeconomically disadvantaged. Furthermore, socioeconomically deprived patients are at risk of inequitable access to heart failure treatment and poor outcomes.
Anna Ohlsson, Nils Eckerdal, Bertil Lindahl, Marianne Hanning, Ragnar Westerling   +4 more
doaj   +1 more source

Pharmacological effects of raas blockade in ischemic nephropathy [PDF]

, 2016
Background: The management of ischemic nephropathy due to atherosclerotic renal artery stenosis has become increasingly conservative in the modern era, with current guidelines recommending optimized medical therapy as the initial step.
Barbano, Biagio, Cianci, Rosario, Coppolino, Giuseppe, Di Mario, Francesca, Farrah, Tariq E., Fuiano, Giorgio, Gigante, Antonietta, Rivoli, Laura, Rosato, Edoardo   +8 more
core   +1 more source