Beyond blood pressure: the renin-angiotensin system as an innovative driver and therapeutic target in pathological scarring. [PDF]
Shi BH +6 more
europepmc +1 more source
Dietary interventions in acute kidney injury: From molecular mechanism to clinical trials
Abstract Ageing impairs renal resilience with an elevated risk of frequent and harmful acute kidney injury (AKI) that causes substantial morbidity and mortality among hospitalized patients. Since different damaging stimuli at the molecular, cellular and functional level contribute to this loss in kidney function, AKI's pathophysiology is heterogeneous ...
Felix C. Koehler +2 more
wiley +1 more source
Kidney Effectiveness and Safety of Adding Spironolactone in Patients With Type 2 Diabetes Receiving Renin-Angiotensin System Inhibitors Therapy. [PDF]
Lin WR +7 more
europepmc +1 more source
Contributions of vascular ageing to late‐onset Alzheimer's disease
Abstract Late‐onset Alzheimer's disease (LOAD) is an age‐related disease that is strongly associated with vascular risk factors and cerebrovascular impairments. As such, changes in the vasculature with advancing age likely contribute to LOAD, but the mechanisms underlying these contributions remain incompletely understood.
Skylyn J. Ferguson +2 more
wiley +1 more source
Gut microbiota dysbiosis affects the local renin-angiotensin system to induce osteoporosis. [PDF]
Zhong K +9 more
europepmc +1 more source
Cerebral blood flow in conscious rats and implications for therapeutic interventions
Abstract Cerebral blood flow (CBF) often becomes compromised in patients suffering from cardiovascular diseases, increasing the risk of neurodegenerative disease and vascular dementia. There is an urgent need for treatments to address cardiovascular risk without compromising brain perfusion, yet the impact of many existing treatments on CBF are not ...
Tonja W. Emans +3 more
wiley +1 more source
Impacts of exercise, renin-angiotensin system modulation or both on skeletal muscle circadian gene expression. [PDF]
Zumbro EL +8 more
europepmc +1 more source
Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou +11 more
wiley +1 more source
Loss of the liver circadian clock affects the expression of intrarenal renin-angiotensin system components. [PDF]
Hassan SA +5 more
europepmc +1 more source

