Results 201 to 210 of about 52,295 (246)
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Adrenomedullin and the renin–angiotensin–aldosterone system
Regulatory Peptides, 2003Despite its positive inotropic effects and its propensity to stimulate the renin system, adrenomedullin (AM) is hypotensive as a result of dramatic reductions in peripheral resistance. Furthermore, it does not appear to increase aldosterone secretion in spite of often vigorous activation of circulating renin.
Christopher J, Charles +5 more
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Hypertension and the Renin–Angiotensin–Aldosterone System
2018Hypertension is defined as a systolic blood pressure > 140 mmHg or a diastolic blood pressure > 90 mmHg. Renin is a key enzyme of the renin-angiotensin-aldosterone system (RAAS), cleaving angiotensinogen to angiotensin I and, thereby, having an impact on the synthesis rate of the effector hormone of the RAAS, angiotensin II. The RAAS is a hormone
Kaschina, Elena +2 more
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Renin-Angiotensin-Aldosteron-System und Fibrinolyse
Medizinische Klinik, 2000Experimental, genetic and clinical evidence suggests that the renin-angiotensin-aldosterone system (RAAS) may participate in the pathogenesis of thromboembolic cardiovascular disorders such as coronary heart disease. This interrelationship may involve mechanisms other than changes in arterial blood pressure. In addition to various possible interactions,
K, Lottermoser +3 more
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Renin-angiotensin-aldosterone system
European Journal of Clinical Pharmacology, 1980There is increased activity of the renin, angiotensin, aldosterone (RAA) system in infancy and childhood. An inverse relationship between plasma renin, aldosterone and age has been demonstrated. In childhood hypertension due to renovascular disease or pyelonephritic scarring peripheral plasma renin is increased.
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The Renin-Angiotensin-Aldosterone System
2019The renin—angiotensin—aldosterone system (RAAS) is one of the oldest hormonal systems—regardless of whether ‘old’ is defined as phylogenetically old, or in the sense of being discovered a long time ago. Originally, the RAAS has been described as a circulating endocrine system, with angiotensinogen being released by the liver, and renin secreted from ...
Steckelings, Ulrike Muscha +1 more
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Imaging the renin-angiotensin-aldosterone system in the heart
Current Heart Failure Reports, 2005The influence of the renin-angiotensin system (RAS) is recognized in cardiac and vascular injury. An extrinsic RAS has been known for decades, and an equally important intrinsic RAS has been discovered recently. The latter leads to pathologic tissue alterations in the absence of systemic stimuli and may be the main source of local tissue effects of RAS.
Jamshid, Shirani +4 more
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Myocardial Fibrosis and the Renin-Angiotensin-Aldosterone System
Journal of Cardiovascular Pharmacology, 1992In both men and women left ventricular hypertrophy (LVH) is the major risk factor associated with the appearance of diastolic and/or systolic myocardial failure. It is not the growth of cardiac myocytes, however, that is responsible for an abnormal structural remodeling of the hypertrophied myocardium in pathologic LVH, but instead, nonmyocyte cells ...
K T, Weber, C G, Brilla
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Ventricular Remodeling and the Renin Angiotensin Aldosterone System
Congestive Heart Failure, 2000Ventricular remodeling in patients with left ventricular systolic dysfunction is an indolent process that is associated with a poor prognosis. Clinical and experimental data support the central role played by the renin‐angiotensin‐aldosterone system in the pathophysiology of remodeling.
R D, Patten, M A, Konstam
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Renin-Angiotensin-Aldosterone System in Hypertrophic Cardiomyopathy
Kardiologiia, 2014Keeping in mind an important role of renin-angiotensin aldosterone system (RAS) in developing of cardiac remodeling and fibrosis, genetic polymorphisms coding its components could have influence with clinical variants of the course. Biomarkers could appear predictors of adverse.
M V, Kozhevnikova +4 more
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Perspectives on the renin-angiotensin-aldosterone system in hypertension
Metabolism, 1974Abstract In the syndrome of hyperaldosteronism, the abnormal electrolyte metabolism, secondary to mineralocorticoid excess, seems to play a predominant pathogenetic role in causing elevation of the blood pressure, since the renin-angiotensin system is depressed and unresponsive.
A H, Vagnucci, A P, Shapiro
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