Results 91 to 100 of about 254,005 (338)

Targeting the renin-angiotensin system to improve cancer treatment: Implications for immunotherapy

Science Translational Medicine, 2017
By reprogramming the tumor microenvironment, renin-angiotensin system inhibitors have the potential to increase effectiveness of immunotherapy. Renin-angiotensin system (RAS) inhibitors (RASi)—widely prescribed for the treatment of cardiovascular ...

semanticscholar   +1 more source

An experimental medicine protocol for exploring the haemodynamic effects of dual agonism at the glucagon‐like peptide‐1 and glucagon receptor in healthy subjects

British Journal of Clinical Pharmacology, EarlyView.
Aims Glucagon‐like peptide‐1 (GLP‐1) and glucagon dual receptor agonists are in clinical development for a range of metabolic conditions, including type 2 diabetes and obesity. The cardiovascular actions at these receptors are well studied, but less is known about their combination.
James Goodman, Victoria E. Parker, Carmel M. McEniery, Giovanni Di Stefano, Annette Hubsch, Evangelia Vamvaka, Jo Helmy, Fotini Kaloyirou, Navazh Jalaludeen, Peter Barker, Lutz Jermutus, Joseph Cheriyan, Philip Ambery, Ian B. Wilkinson   +13 more
wiley   +1 more source

Effect of a SGLT2 inhibitor on the systemic and intrarenal renin–angiotensin system in subtotally nephrectomized rats

Journal of Pharmacological Sciences, 2018
We aimed to examine the effects of a sodium glucose co-transporter 2 (SGLT2) inhibitor on systemic and intrarenal renin–angiotensin system (RAS) in subtotally nephrectomized non-diabetic rats, a model of chronic kidney disease (CKD).
Lei Li, Yoshio Konishi, Takashi Morikawa, Yifan Zhang, Chizuko Kitabayashi, Hideki Kobara, Tsutomu Masaki, Daisuke Nakano, Hirofumi Hitomi, Hiroyuki Kobori, Akira Nishiyama   +10 more
doaj   +1 more source

Changes in renal WT-1 expression preceding hypertension development [PDF]

, 2016
Background: Hypertension is a public health problem with mostly unknown causes, and where strong hereditary genetic alterations have not been fully elucidated. However, the use of experimental models has provided valuable information.
Abud, María Angélica, Calvo, Juan Pablo, Casarotto, Mariana, Cuello Carrión, Fernando Darío, Ferder, León, Fornes, Miguel Walter, García, Isabel Mercedes, Manucha, Walter Ariel Fernando, Mazzei, Luciana Jorgelina   +8 more
core   +2 more sources

Causes and Consequences of the Dysregulated Maternal Renin-Angiotensin System in Preeclampsia

Frontiers in Endocrinology, 2019
A healthy pregnancy outcome depends on the activation of the renin-angiotensin-aldosterone system (RAAS) as a regulated, integrated response to the growing demands of the conceptus.
E. Lumbers, Sarah J. Delforce, A. Arthurs, K. Pringle   +3 more
semanticscholar   +1 more source

Endothelium‐Independent Relaxation of Alkaloid Boldine in Isolated Aortas From Normotensive and Hypertensive Rats: Participation of Ca2+ Channels

Chemistry &Biodiversity, EarlyView.
Involvement of Ca2+ channels in boldine‐induced vascular relaxation. ABSTRACT The regulation of vascular tone plays a fundamental role in blood pressure homeostasis and still represents a significant challenge in clinical practice. Boldine, a naturally occurring alkaloid from Peumus boldus, has emerged as a compound of interest due to its therapeutic ...
Martina Odebrecht Cavichiolo, Rita de Cássia Vilhena da Silva, Valdir Cechinel Filho, Priscila de Souza   +3 more
wiley   +1 more source

THE CORRELATION BETWEEN THE RENIN AT ALDOSTERONE SYSTEM – ARTERIAL HYPERTENSION AND HORMONAL MECHANISMS

Romanian Journal of Oral Rehabilitation
The aim of this study was to evaluate the effect of the renin- angiotensin- aldosterone system on blood pressure from a hormonal perspective. Additionally, the correlation between cardiovascular pathology and the mechanisms of this system was examined.
Liviu Stafie, Cristina Maria Gavrilescu, Cristian Cojocaru, Elena Cojocaru, Cristina Oprisa, Luiza Pohaci Antonesei, Norin Forna, Roxana Mihaela Barbu   +7 more
doaj   +1 more source

Central injection of captopril inhibits the blood pressure response to intracerebroventricular choline

Brazilian Journal of Medical and Biological Research, 2001
In the present study, we investigated the involvement of the brain renin-angiotensin system in the effects of central cholinergic stimulation on blood pressure in conscious, freely moving normotensive rats. In the first step, we determined the effects of
N. Isbil-Buyukcoskun, G. Gulec, K. Ozluk, I.H. Ulus   +3 more
doaj   +1 more source

Blockade of the renin-angiotensin system [PDF]

, 2002
The renin-angiotensin-aldosterone system plays a key role in the regulation of fluid and electrolyte balance. Angiotensin-converting enzyme inhibitors inhibit angiotensin-converting enzyme and have been shown to be effective in many cardiovascular ...
Cheung, BMY
core  

Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter [PDF]

, 2009
BACKGROUND. Fine particulate matter [aerodynamic diameter ≤ 2.5 μm (PM2.5)] has been associated with autonomic dysregulation. OBJECTIVE. We hypothesized that PM2.5 influences postural changes in systolic blood pressure (ΔSBP) and in diastolic blood ...
Andrea Baccarelli, Audrey Poon, Augusto A. Litonjua, Benjamini Y, David Sparrow, Elissa Wilker, Ferris BG, Helen Suh, Joel Schwartz, Murray A. Mittleman, Pantel Vokonas, Poon AH, Poon AH, Robert O. Wright   +13 more
core   +3 more sources