Results 61 to 70 of about 928,186 (425)

Clinical Determinants and Prognostic Implications of Renin and Aldosterone in Patients with Symptomatic Heart Failure [PDF]

, 2020
Aims Activation of the renin-angiotensin-aldosterone system plays an important role in the pathophysiology of heart failure (HF) and has been associated with poor prognosis.
Anker, Stefan D., Dickstein, Kenneth, Duarte, Kevin, Ferreira, Joao Pedro, Girerd, Nicolas, Kobayashi, Masatake, Lamiral, Zohra, Lang, Chim C., Metra, Macro, Ng, Leong L., Preud'homme, Gregoire, Rossignol, Patrick, Samani, Nilesh J., Stienen, Susan, ter Maaten, Jozine M., van Veldhuisen, Dirk J., Voors, Adriaan A., Zannad, Faiez   +17 more
core   +4 more sources

Use of guideline‐recommended medical therapy in patients with heart failure and chronic kidney disease: from physician's prescriptions to patient's dispensations, medication adherence and persistence

European Journal of Heart Failure, Volume 24, Issue 11, Page 2185-2195, November 2022., 2022
Patients with heart failure and chronic kidney disease are less likely to receive and persist on guideline‐recommended medical therapies. Aim Half of heart failure (HF) patients have chronic kidney disease (CKD) complicating their pharmacological management.
Roemer J. Janse, Edouard L. Fu, Ulf Dahlström, Lina Benson, Bengt Lindholm, Merel van Diepen, Friedo W. Dekker, Lars H. Lund, Juan‐Jesus Carrero, Gianluigi Savarese   +9 more
wiley   +1 more source

An Update on the Tissue Renin Angiotensin System and Its Role in Physiology and Pathology

Journal of Cardiovascular Development and Disease, 2019
In its classical view, the renin angiotensin system (RAS) was defined as an endocrine system involved in blood pressure regulation and body electrolyte balance.
A. Nehme, Fouad A. Zouein, Z. Zayeri, K. Zibara   +3 more
semanticscholar   +1 more source

hESCs‐derived Organoids Achieve Liver Zonation Features through LSEC Modulation

Advanced Science, EarlyView.
This article addresses the absence of zonation features in current organoid models by co‐culturing human embryonic stem cell‐derived hepatocytes with liver sinusoidal endothelial cells exhibiting distinct zonal characteristics. It demonstrates that differential WNT2 signaling from endothelial cells modulates hepatocyte zonation and metabolic functions,
Yuying Zhang, Chenyan Huang, Lei Sun, Lyu Zhou, Yudi Niu, Kaini Liang, Bingjie Wu, Peng Zhao, Zhiqiang Liu, Xiaolin Zhou, Peng Zhang, Jianchen Wu, Jie Na, Yanan Du   +13 more
wiley   +1 more source

Evolution of tricuspid regurgitation after transcatheter edge‐to‐edge mitral valve repair for secondary mitral regurgitation and its impact on mortality

European Journal of Heart Failure, Volume 24, Issue 11, Page 2175-2184, November 2022., 2022
Aim To evaluate short‐term changes in tricuspid regurgitation (TR) after transcatheter edge‐to‐edge mitral valve repair (M‐TEER) in secondary mitral regurgitation (SMR), their predictors and impact on mortality. Methods and results This is a retrospective analysis of SMR patients undergoing successful M‐TEER (post‐procedural mitral regurgitation ≤2 ...
Marianna Adamo, Matteo Pagnesi, Giulia Ghizzoni, Rodrigo Estévez‐Loureiro, Sergio Raposeiras‐Roubin, Daniela Tomasoni, Davide Stolfo, Gianfranco Sinagra, Antonio Popolo Rubbio, Francesco Bedogni, Federico De Marco, Cristina Giannini, Anna Sonia Petronio, Laura Stazzoni, Tomás Benito‐González, Felipe Fernández‐Vázquez, Carmen Garrote‐Coloma, Cosmo Godino, Eustachio Agricola, Andrea Munafò, Isaac Pascual, Pablo Avanzas, Victor Léon, Antonio Montefusco, Paolo Boretto, Stefano Pidello, Vanessa Moñivas‐Palomero, Maria Del Trigo, Elena Biagini, Alessandra Berardini, Francesco Saia, Luis Nombela‐Franco, Gabriela Tirado‐Conte, Alberto De Augustin, Berenice Caneiro‐Queija, Antonio De Luca, Luca Branca, Gregorio Zaccone, Laura Lupi, Erik Lipsic, Adriaan Voors, Marco Metra   +41 more
wiley   +1 more source

Acute Kidney Injury in a Case Series of Patients with Confirmed COVID-19 (Coronavirus Disease 2019): Role of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Blockade

Case Reports in Nephrology, 2020
The renin-angiotensin system plays a very critical role in hypertension, diabetes, and kidney and heart diseases. The blockade of the renin-angiotensin system results in the prevention of progression of renal and cardiac damage.
Avantika Chenna, Venu Madhav Konala, Subhasish Bose, Sasmit Roy, Bhaskar Reddy Madhira, Vijay Gayam, Srikanth Naramala, Sreedhar Adapa   +7 more
doaj   +1 more source

Phenotypic dissection of the mouse Ren-1(d) knockout by complementation with human renin [PDF]

, 2017
Normal renin synthesis and secretion is important for the maintenance of juxtaglomerular apparatus architecture. Mice lacking a functional Ren-1d gene are devoid of renal juxtaglomerular cell granules and exhibit an altered macula densa morphology.
Abel, Abel, Abel, Armin Kurtz, Berka, Berka, Charlotte Buckley, Christensen, Christopher J. Kenyon, Clark, Dickinson, Dominik Steppan, Goldstone, Greenberg, Hackenthal, Helen Christian, Huerta-Ocampo, Janos Peti-Peterdi, John J. Mullins, Kurtz, Linda J. Mullins, Matthew G.F. Sharp, Mullins, Mullins, Ogawa, Oliver, Panthier, Peti-Peterdi, Peti-Peterdi, Peti-Peterdi, Peti-Peterdi, Peti-Peterdi, Piccini, Robert J. Nelson, Rohrwasser, Sabrina Semprini, Sharp, Sinn, Skött, Steppan, Stewart Fleming, Toffelmire, Yan, Yang   +43 more
core   +3 more sources

Screening and Identification of Novel DNA Aptamer for Targeted Delivery to Injured Podocytes in Glomerular Diseases

Advanced Science, EarlyView.
This study develops RLS‐2, a high‐affinity aptamer that specifically targets injured podocytes, making it a promising candidate for targeted drug delivery. In vitro, RLS‐2 shows stability, specificity, efficient siRNA delivery via AsiCs, and uptake by podocytes.
Chao Zhou, Zhaofeng Luo, Zheng Zhang, Qing Ye, Dongjie Wang, Hanyan Meng, Jiayu Zhang, Shifan Zhu, Lidan Hu, Jianhua Mao   +9 more
wiley   +1 more source

Trajectories in New York Heart Association functional class in heart failure across the ejection fraction spectrum: data from the Swedish Heart Failure Registry

European Journal of Heart Failure, Volume 24, Issue 11, Page 2093-2104, November 2022., 2022
Stable New York Heart Association (NYHA) class over time was much more frequent than an improvement or a worsening. Follow‐up NYHA class assessment, but not change in NYHA class over time, was independently associated with better prognosis. CI, confidence interval; HR, hazard ratio.
Felix Lindberg, Lars H. Lund, Lina Benson, Ulf Dahlström, Patric Karlström, Cecilia Linde, Giuseppe Rosano, Gianluigi Savarese   +7 more
wiley   +1 more source

THE ROLE OF ANGIOTENSINOGEN IN ATHEROSCLEROSIS AND OBESITY [PDF]

, 2014
Angiotensinogen is the only known precursor in the renin-angiotensin system, a hormonal system best known as an essential regulator of blood pressure and fluid homeostasis.
Wu, Congqing
core   +1 more source