Results 81 to 90 of about 254,005 (338)

Revisiting the monocrotaline‐treated rat as a model of inflammatory lung disease: COVID‐19 and future pandemic threats?

Animal Models and Experimental Medicine, EarlyView.
In this review, the pathological, molecular, and cellular changes observed in the COVID‐19 lung are compared to those in the laboratory rat treated with monocrotaline (MCT). Similarities that reflect common changes associated with inflammation and endothelial cell dysfunction are observed in both states, leading to a lung pathology characterized by ...
Luke P. Kris, Dani‐Louise Dixon, Shailesh Bihari, Jillian M. Carr   +3 more
wiley   +1 more source

Renin-Angiotensin-Aldosterone System, Glucose Metabolism and Incident Type 2 Diabetes Mellitus: MESA. [PDF]

, 2018
Background Mechanistic studies suggest that aldosterone impairs glucose metabolism. We investigated the cross-sectional associations of aldosterone and plasma renin activity with fasting plasma glucose, insulin resistance ( IR ), β-cell function, and ...
Allison, Matthew A, Echouffo Tcheugui, Justin B, Effoe, Valery S, Golden, Sherita H, Hsueh, Willa A, Joseph, Joshua J   +5 more
core   +1 more source

Effect of Cyclooxygenase(COX)-1 and COX-2 inhibition on furosemide-induced renal responses and isoform immunolocalization in the healthy cat kidney [PDF]

, 2015
BACKGROUND: The role of cyclooxygenase(COX)-1 and COX-2 in the saluretic and renin-angiotensin responses to loop diuretics in the cat is unknown. We propose in vivo characterisation of isoform roles in a furosemide model by administering non-steroidal ...
A Hayes, B Mann, B Rose, B Rose, B Rose, CM Hao, DA Heller, DO Stichtenoth, F Catella-Lawson, F Nantel, G Giovanni, H Syme, H. Syme, J Hippisley-Cox, J Peti-Peterdi, J. Elliott, J. N. King, JA Jakobsen, K Schumacher, K. Smith, KA Kirchner, KL Therland, KN Khan, KN Khan, L Pelligand, L Pelligand, L. Pelligand, M Komhoff, M Meskell, M Sabbatini, N. Suemanotham, P. Lees, PA Friedman, RC Harris, RC Harris, RE Jepson, S Yu, V Campean, V Sreenivasan, VB Schmid, W. Seewald, WA Corsini, XR He   +42 more
core   +2 more sources

Renin-Angiotensin System and Cardiovascular Functions

Arteriosclerosis, Thrombosis and Vascular Biology, 2018
The renin-angiotensin system plays critical roles in maintaining normal cardiovascular functions and contributes to a spectrum of cardiovascular diseases.
Chia-Hua Wu, S. Mohammadmoradi, Jeff Z. Chen, Hisashi Sawada, A. Daugherty, Hong S. Lu   +5 more
semanticscholar   +1 more source

Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

British Journal of Clinical Pharmacology, EarlyView.
Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić, Marta Kučan Štiglić, Ana Jelaković, Bojan Jelaković, Dinko Vitezić   +4 more
wiley   +1 more source

High salt intake damages the heart through activation of cardiac (pro) renin receptors even at an early stage of hypertension. [PDF]

PLoS ONE, 2015
It has not yet been fully elucidated whether cardiac tissue levels of prorenin, renin and (P)RR are activated in hypertension with a high salt intake.
Yuka Hayakawa, Takuma Aoyama, Chiharu Yokoyama, Chihiro Okamoto, Hisaaki Komaki, Shingo Minatoguchi, Masamitsu Iwasa, Yoshihisa Yamada, Itta Kawamura, Masanori Kawasaki, Kazuhiko Nishigaki, Atsushi Mikami, Fumiaki Suzuki, Shinya Minatoguchi   +13 more
doaj   +1 more source

Monotherapy with major antihypertensive drug classes and risk of hospital admissions for mood disorders [PDF]

, 2016
Major depressive and bipolar disorders predispose to atherosclerosis, and there is accruing data from animal model, epidemiological, and genomic studies that commonly used antihypertensive drugs may have a role in the pathogenesis or course of mood ...
Boal, Angela H., Dominiczak, Anna F., Mccallum, Linsay, Muir, Scott, Padmanabhan, Sandosh, Smith, Daniel J., Touyz, Rhian M.   +6 more
core   +1 more source

Effectiveness and safety of combining thiazides with loop diuretics vs. loop diuretics monotherapy in patients with acute decompensated heart failure: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study investigated factors associated with and outcomes of combined loop diuretics with hydrochlorothiazide (HCTZ) for acute decompensated heart failure (ADHF). Methods In this retrospective study, adults hospitalized for ADHF and who received intravenous loop diuretics between January 2016 and March 2023 were enrolled.
Chia‐Chen Hsu, Hsien‐Chih Chiu, Ju‐Chieh Wung, Yueh‐Ching Chou, Yuh‐Lih Chang, Chian‐Ying Chou, Chin‐Chou Huang   +6 more
wiley   +1 more source

Dietary Potassium Downregulates Angiotensin-I Converting Enzyme, Renin, and Angiotensin Converting Enzyme 2

Frontiers in Pharmacology, 2020
BackgroundThe importance of dietary potassium in health and disease has been underestimated compared with that placed on dietary sodium. Larger effort has been made on reduction of sodium intake and less on the adequate dietary potassium intake, although
Carlos P. Vio, Carlos P. Vio, Pedro Gallardo, Carlos Cespedes, Carlos Cespedes, Daniela Salas, Jessica Diaz-Elizondo, Natalia Mendez   +7 more
doaj   +1 more source

A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI [PDF]

, 2013
BACKGROUND: Acute kidney injury (AKI) is a frequent condition in hospitalised patients undergoing major surgery or the critically ill and is associated with increased mortality.
Delles, C., Husi, H., Mischak, H., Mullen, W., Ortiz, A., Sanchez-Niño, M., Vlahou, A.   +6 more
core   +3 more sources