Results 161 to 170 of about 113,930 (262)

Kinetic and structural characterisation of domain‐specific angiotensin I‐converting enzyme inhibition by captopril, rentiapril and zofenoprilat

The FEBS Journal, EarlyView.
Angiotensin I‐converting enzyme (ACE) contains two catalytic domains (nACE and cACE) and is a key therapeutic target for hypertension and cardiovascular disease. Current ACE inhibitors (ACEi) nonselectively inhibit both domains, causing adverse effects. Selective inhibition requires an understanding of domain‐specific binding.
Kyle S. Gregory, Vinasha Ramasamy, Edward D. Sturrock, K. Ravi Acharya   +3 more
wiley   +1 more source

Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction‐Associated Steatohepatitis

Hepatology Research, EarlyView.
Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura, Aya Naiki‐Ito, Xiaochen Kuang, Akihiro Murakami, Masayuki Komura, Takanori Suzuki, Hiroyuki Kato, Yuko Nagayasu, Kentaro Matsuura, Kei Fujiwara, Hiromi Kataoka, Satoru Takahashi   +11 more
wiley   +1 more source

Structure-Based Design and In Silico Evaluation of a Lipophilic Cyclooctanoyl- Derivative as a Renin Inhibitor: Lessons from Withdrawn Aliskiren. [PDF]

Int J Mol Sci
Pavlos D, Petsas E, Chatzipieris FP, Mavromoustakos T, Chasapis CT.   +4 more
europepmc   +1 more source

Evaluation of Body Position Association with Diuretic Response and Neurohormonal Activation in Patients with Acutely Decompensated Heart Failure. [PDF]

Biomedicines
Guzik M, Tymków R.
europepmc   +1 more source

Mechanisms of hesperetin in alleviating diabetic nephropathy: Network pharmacology, molecular docking, and experimental validation

Journal of Diabetes Investigation, EarlyView.
Hesperetin increases cell viability and reduces cell apoptosis, ferroptosis, release of inflammatory cytokines, and oxidative stress of human kidney tubular cells via repressing IGF1R expression. ABSTRACT Background Diabetic nephropathy (DN) accounts for approximately 50% of chronic kidney disease cases.
Yiwen Guo, Fengjiao Zhang, Yu Jin, Menglu Zhu, Zhiqiang Kang   +4 more
wiley   +1 more source

Quarterly injectable hormonal contraceptive does not increase the activity of the renin-angiotensin-aldosterone system in women without cardiovascular risk factors. [PDF]

Rev Bras Ginecol Obstet
de Oliveira AM, Dos Santos PA, Souza PES, do Sacramento MS, Souza CF, Ladeia AMT, Petto J.   +6 more
europepmc   +1 more source

Renin [PDF]

, 2020
openaire   +1 more source

Glycemic control and renal function decline in patients with chronic coronary syndrome: A multicenter cohort study

Journal of Diabetes Investigation, EarlyView.
Achieving HbA1c of 6.5–6.9% is associated with a reduced risk of renal complications in patients with diabetes and chronic coronary syndrome. Abstract Aims/Introduction Diabetes mellitus significantly contributes to renal complications, especially in patients with coronary artery disease (CAD).
An‐Yu Cheng, Chin‐Chou Huang, Hsin‐Bang Leu, Wei‐Hsian Yin, Wei‐Kung Tseng, Yen‐Wen Wu, Tsung‐Hsien Lin, Hung‐I Yeh, Kuan‐Cheng Chang, Ji‐Hung Wang, Chau‐Chung Wu, Jaw‐Wen Chen   +11 more
wiley   +1 more source

Clinical significance of renal histological diagnosis in patients with type 2 diabetes and proteinuria atypical for diabetic nephropathy

Journal of Diabetes Investigation, EarlyView.
ABSTRACT Background/Aim Most patients with proteinuria are considered to have typical diabetic nephropathy (DN). However, when proteinuria occurs without diabetic retinopathy, with hematuria, or persists despite strict glycemic and blood pressure control, it is considered atypical for DN and warrants further evaluation for non‐DN via kidney biopsy ...
Shogo Kuwagata, Masami Chin‐Kanasaki, Aki Yamada, Tomonori Sakae, Nahomi Ishimoto, Yoshimi Imamura‐Uehara, Kosuke Yamahara, Mako Yasuda‐Yamahara, Sho Sugahara, Yuki Tanaka‐Sasaki, Natsumi Kuwata, Kimihiro Nishimura, Koichiro Murata, Itsuko Miyazawa, Shogo Ida, Natsuko Ohashi, Shinji Kume   +16 more
wiley   +1 more source