Results 281 to 290 of about 468,820 (359)

[Retracted] Na⁺/K⁺‑ATPase DR region‑specific antibody protects U251 cells against hypoxia reperfusion‑induced injury via the PI3K/AKT and ERK pathways. [PDF]

Mol Med Rep
Gong H, Lü P, Zhang J, Li D, Zheng J, Song J.   +5 more
europepmc   +1 more source

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

The crucial role of SETDB1 in structural and functional transformation of epithelial cells during regeneration after intestinal ischemia reperfusion injury

Makoto Ikenoue, Narantsog Choijookhuu, Koichiro Yano, Fidya, Nobuyasu Takahashi, Takumi Ishizuka, Shinichiro Shirouzu, Yu Yamaguma, Kengo Kai, Kazuhiro Higuchi, Akira Sawaguchi, Atsushi Nanashima, Yoshitaka Hishikawa   +12 more
openalex   +2 more sources

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

The Effects of Angiotensin Receptor Neprilysin Inhibitor on Endoplasmic Reticulum Stress in Doxorubicin‐Mediated Cardiomyopathy‐Associated Heart Failure Model in Rats

Journal of Applied Toxicology, EarlyView.
ABSTRACT One of the most serious complications associated with the use of the chemotherapeutic agent doxorubicin (DOX) is cardiomyopathy. Although cardioprotective drugs such as angiotensin receptor‐neprilysin inhibitors (ARNI) are used to prevent cardiomyopathy in DOX patients, no studies have reported the relationship between ARNI and endoplasmic ...
Mert Unvan, Meryem İlkay Karagül, Hatice Oruç Demirbağ, Ebru Balli   +3 more
wiley   +1 more source

Correction to "A Meta-Analysis of Randomized Controlled Trials (RCTs) Investigating the Efficacy and Safety of Acupuncture in Treating Myocardial Ischemia/Reperfusion (I/R) Injury". [PDF]

Cardiol Res Pract
europepmc   +1 more source

Cerebral Infarction: Epidemiology, Classification, Mechanisms, Diagnosis, and Management. [PDF]

MedComm (2020)
Zhang M, Hou J, Kuang J, Hao L, Yang Z.
europepmc   +1 more source

From DNA Methylation Microarray to Digital PCR: A Stepwise Strategy for Tissue Specific cfDNA Biomarker Development

Journal of Clinical Laboratory Analysis, EarlyView.
Overview of a DNA methylation biomarker development pipeline, from discovery and assay design to screening, performance evaluation, and specificity testing in clinical sample matrices. ABSTRACT Background Tissue‐specific cell‐free DNA (cfDNA) offers promise as a minimally invasive biomarker of organ injury.
David H. Murray, Nicky Boulter, Shanon Ranjit, Natasha M. Rogers, Sarah Kummerfeld, Jason P. Ross, Rodney J. Scott   +6 more
wiley   +1 more source

Normothermic Machine Perfusion vs. Static Cold Storage for DBD Liver Transplantation in High‐MELD Recipients: A Single‐Center Retrospective Study

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
ABSTRACT Background and Purpose While normothermic machine perfusion (NMP) has benefits over static cold storage (SCS), its efficacy in high‐acuity recipients with high Model for End‐Stage Liver Disease (MELD) scores, particularly using a back‐to‐base application model, is not well established.
Yuzuru Sambommatsu, Daisuke Imai, Kush Savsani, Mallika Datta, Junpei Tarashi, Jacob Hallesy, Samuel Wolfe, Isao Yokota, Seung Duk Lee, David A. Bruno   +9 more
wiley   +1 more source