Results 121 to 130 of about 205,704 (259)

Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS

Advanced Science, EarlyView.
ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi, Di Tang, Johan Malmström, Yasaman Karami, Hamed Khakzad   +4 more
wiley   +1 more source

TCRcloud: a global visualization tool for T-cell and B-cell receptor transcripts. [PDF]

J Transl Med
de Sousa E, Lérias JR, Gorgulho CM, Chaves-Ferreira M, Balan V, Pan W, Byrne-Steele M, Wang Z, Han J, Gama-Carvalho M, Maeurer M.   +10 more
europepmc   +1 more source

A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long‐Read Data

Advanced Science, EarlyView.
SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Shuai Wang, Xuedong Wang, Mengyao Wang, Qian Zhou, Lusheng Wang, Shuai Cheng Li   +5 more
wiley   +1 more source

Decoding adaptive immunity: advanced strategies in T and B cell repertoire analysis. [PDF]

J Transl Med
Yu X, Peng N, Pan W, Xie S, Tang C, Wang X, Liu H, Shi Y, He Y, Wu W, Weber D, Nie L, Liu Y, Chen Z, Deng Y, Byrne-Steele M, Wang Z, Li S.   +17 more
europepmc   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Longitudinal profiling of antigen receptor gene repertoire dynamics in kidney transplant recipients after multiple SARS-CoV-2 vaccinations. [PDF]

Immunohorizons
Mingos A, Pechlivanis N, Karakatsoulis G, Anastasiadou A, Gkoliou G, Vastarouchas N, Siorenta A, Marinaki S, Tsoutsoura P, Papamentzelopoulou M, Pitiriga V, Psichogiou M, Hatzakis A, Stamatopoulos K, Vlachonikola E, Chatzidimitriou A.   +15 more
europepmc   +1 more source

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, EarlyView.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

„Ich geh Kino“ oder „… ins Kino“?

Zeitschrift für Sprachwissenschaft, 2016
Wiese Heike, Pohle Maria
doaj   +1 more source

TCR sequencing in cancer immunology and immunotherapy: what, when, where, why, and how. [PDF]

J Immunother Cancer
Nose Y, Figueiredo I, Tuballes K, Del Valle DM, Gonsalves TR, Guo R, Ioannou G, Cabal R, Gonzalez-Kozlova E, Gnjatic S.   +9 more
europepmc   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source