Results 31 to 40 of about 205,704 (259)

Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice

eLife, 2015
T-cell recognition of self and foreign peptide antigens presented in major histocompatibility complex molecules (pMHC) is essential for life-long immunity.
Neha R Deshpande, Heather L Parrish, Michael S Kuhns   +2 more
doaj   +1 more source

The influences of microbial colonisation and germ-free status on the chicken TCRβ repertoire

Frontiers in Immunology, 2023
Microbial colonisation is paramount to the normal development of the immune system, particularly at mucosal sites. However, the relationships between the microbiome and the adaptive immune repertoire have mostly been explored in rodents and humans. Here,
Stefan Dascalu, Stefan Dascalu, Stephen G. Preston, Stephen G. Preston, Robert J. Dixon, Patrik G. Flammer, Steven Fiddaman, Amy Boyd, Joshua E. Sealy, Jean-Remy Sadeyen, Bernd Kaspers, Philippe Velge, Munir Iqbal, Michael B. Bonsall, Adrian L. Smith   +14 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Single-B cell analysis correlates high-lactate secretion with stress and increased apoptosis

Scientific Reports
While cellular metabolism was proposed to be a driving factor of the activation and differentiation of B cells and the function of the resulting antibody-secreting cells (ASCs), the study of correlations between cellular metabolism and functionalities ...
Olivia T. M. Bucheli, Daniela Rodrigues, Kevin Portmann, Aline Linder, Marina Thoma, Cornelia Halin, Klaus Eyer   +6 more
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Strategies for Generating Diverse Antibody Repertoires Using Transgenic Animals Expressing Human Antibodies

Frontiers in Immunology, 2018
Therapeutic molecules derived from antibodies have become a dominant class of drugs used to treat human disease. Increasingly, therapeutic antibodies are discovered using transgenic animal systems that have been engineered to express human antibodies ...
Weihsu C. Chen, Christopher M. Murawsky
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Epigenetic Enhancer Marks and Transcription Factor Binding Influence Vκ Gene Rearrangement in Pre-B Cells and Pro-B Cells

Frontiers in Immunology, 2018
To date there has not been a study directly comparing relative Igκ rearrangement frequencies obtained from genomic DNA (gDNA) and cDNA and since each approach has potential biases, this is an important issue to clarify.
Eden Kleiman, Salvatore Loguercio, Ann J. Feeney   +2 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Multifactorial determinants of NK cell repertoire organization: insights into age, sex, KIR genotype, HLA typing, and CMV influence

Frontiers in Immunology
IntroductionPolymorphisms in the KIR and HLA genes contribute to the diversity of the NK cell repertoire. Extrinsic factors also play a role in modifying this repertoire. The best example is cytomegalovirus, which promotes the expansion of memory-like NK
Enora Ferron, Enora Ferron, Enora Ferron, Gaëlle David, Gaëlle David, Gaëlle David, Catherine Willem, Catherine Willem, Catherine Willem, Nolwenn Legrand, Nolwenn Legrand, Nolwenn Legrand, Perla Salameh, Perla Salameh, Perla Salameh, Laetitia Anquetil, Laetitia Anquetil, Alexandre Walencik, Alexandre Walencik, Ketevan Gendzekhadze, Katia Gagne, Katia Gagne, Katia Gagne, Katia Gagne, Christelle Retière, Christelle Retière, Christelle Retière   +26 more
doaj   +1 more source