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Frontiers in Immunology, 2023 The adaptive immune system has the extraordinary ability to produce a broad range of immunoglobulins that can bind a wide variety of antigens. During adaptive immune responses, activated B cells duplicate and undergo somatic hypermutation in their B-cell
Aurelien Pelissier +6 more
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Distinct, developmental stage-specific activation mechanisms of trypanosome VSG genes [PDF]
, 1990 The metacyclic form of African trypanosomes is the first to express genes for the Variant Surface Glycoprotein (VSG) and it uses an unusually predictable subset of the VSG gene repertoire.
Barry, J D +3 more
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Frontiers in ImmunologyIntroductionHuman peripheral blood mononuclear cells (hPBMCs) are widely used in fundamental research and clinical applications as studying their responses to in vitro activation is an effective way to uncover functional alterations and disease ...
Aline Linder +3 more
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Quality assessment of gene repertoire annotations with OMArk
Nature BiotechnologyIn the era of biodiversity genomics, it is crucial to ensure that annotations of protein-coding gene repertoires are accurate. State-of-the-art tools to assess genome annotations measure the completeness of a gene repertoire but are blind to other errors,
Yannis Nevers +6 more
semanticscholar +1 more source
Human Vaccines & Immunotherapeutics, 2021 The Hepatitis B (HB) vaccine is efficacious in preventing hepatitis B virus infection. However, the association between antibody response to the HB vaccine and dynamic immune repertoire changes in different cell subsets remains unclear.
Miaoxian Zhao +8 more
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Evolution of T cell receptor beta loci in salmonids
Frontiers in Immunology, 2023 T-cell mediated immunity relies on a vast array of antigen specific T cell receptors (TR). Characterizing the structure of TR loci is essential to study the diversity and composition of T cell responses in vertebrate species.
Pierre Boudinot +6 more
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Analyzing Immunoglobulin Repertoires [PDF]
Frontiers in Immunology, 2018 Somatic assembly of T cell receptor and B cell receptor (BCR) genes produces a vast diversity of lymphocyte antigen recognition capacity. The advent of efficient high-throughput sequencing of lymphocyte antigen receptor genes has recently generated unprecedented opportunities for exploration of adaptive immune responses.
Chaudhary, Neha, Wesemann, Duane
openaire +4 more sources
Emotion, 2020 Emotion regulation (ER) repertoire-the range of different ER strategies an individual utilizes across situations-is assumed to enable more adaptive ER and greater well-being.
G. Grommisch +6 more
semanticscholar +1 more source
Inferring processes underlying B-cell repertoire diversity
, 2015 We quantify the VDJ recombination and somatic hypermutation processes in human B-cells using probabilistic inference methods on high-throughput DNA sequence repertoires of human B-cell receptor heavy chains.
Aleksandra M. Walczak +10 more
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Understanding the human antibody repertoire
mAbs, 2020 The origins of the various elements in the human antibody repertoire have been and still are subject to considerable uncertainty. Uncertainty in respect of whether the various elements have always served a specific defense function or whether they were ...
A. Rees
semanticscholar +1 more source