Results 51 to 60 of about 705,796 (337)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Single-B cell analysis correlates high-lactate secretion with stress and increased apoptosis

open access: yesScientific Reports
While cellular metabolism was proposed to be a driving factor of the activation and differentiation of B cells and the function of the resulting antibody-secreting cells (ASCs), the study of correlations between cellular metabolism and functionalities ...
Olivia T. M. Bucheli   +6 more
doaj   +1 more source

Self-recognition drives the preferential accumulation of promiscuous CD4+ T-cells in aged mice

open access: yeseLife, 2015
T-cell recognition of self and foreign peptide antigens presented in major histocompatibility complex molecules (pMHC) is essential for life-long immunity.
Neha R Deshpande   +2 more
doaj   +1 more source

Architectural perspectives in the cathedral of Palermo : image-based modeling for cultural heritage understanding and enhancement [PDF]

open access: yes, 2015
Palermo off ers a repertoire of both artistic and architectural solid perspective of great beauty and in large quantity. This paper addresses the problem of the 3D survey of these works and their related study through the use of image-based modelling
Inzerillo, Laura, Santagati, Cettina
core   +2 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

Beluga whale (Delphinapterus leucas) vocalizations and call classification from the eastern Beaufort Sea population [PDF]

open access: yes, 2015
Funding was provided by the Bureau of Ocean Energy Management under InterAgency Agreement M09PG00016. E.C.G. was supported by a National Research Council (National Academy of Sciences) Postdoctoral Fellowship.Beluga whales, Delphinapterus leucas, have a ...
Berchok, Catherine   +2 more
core   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

open access: yesFEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz   +3 more
wiley   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

open access: yesFEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik   +3 more
wiley   +1 more source

Three phases in the evolution of the standard genetic code: how translation could get started [PDF]

open access: yes, 2007
A primordial genetic code is proposed, having only four codons assigned, GGC meaning glycine, GAC meaning aspartate/glutamate, GCC meaning alanine-like and GUC meaning valine-like.
van der Gulik, Peter
core   +1 more source

The size of the immune repertoire of bacteria

open access: yes, 2019
Some bacteria and archaea possess an immune system, based on the CRISPR-Cas mechanism, that confers adaptive immunity against phage. In such species, individual bacteria maintain a "cassette" of viral DNA elements called spacers as a memory of past ...
Balasubramanian, Vijay   +3 more
core   +1 more source

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