Results 251 to 260 of about 59,366 (303)

Texoskeletons: Developing the Fundamental Technologies for Creating Intelligent Soft Robotic Clothing With Integrated 1D Sensors and Actuators

Advanced Functional Materials, EarlyView.
ABSTRACT Traditional wearable exoskeletons rely on rigid structures, which limit comfort, flexibility, and everyday usability. This work introduces the fundamental technologies to create the first soft, lightweight, intelligent textile‐based exoskeletons (Texoskeletons) built using 1D sensors and actuators.
Amy Lukomiak, Rameesh Bulathsinghala, Jack Varga, Shuxin Meng, Kalana Marasinghe, Imaad Refai, Biyon Fernando, Amitkumar Patel, Chamika M. Halloluwa‐Arachchige, Carlos Oliveira, Arash M. Shahidi, Zahra Rahemtulla, Alexander Turner, Ziyun Ding, Bernard X. W. Liew, Andy Kerr, Ezio Preatoni, Theo Hughes‐Riley, Ishara Dharmasena, Pasindu Lugoda   +19 more
wiley   +1 more source

Translational Considerations for Injectable Biomaterials and Bioscaffolds to Repair and Regenerate Brain Tissue

Advanced Healthcare Materials, EarlyView.
The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

Advanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim, Ella‐Louise Handley, Daniel Grant, Lizi M. Hegarty, Elaine Emmerson, Anthony Callanan   +5 more
wiley   +1 more source

Lysosome‐Acidifying Nanoparticles Rescue A30P α‐Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease

Advanced Healthcare Materials, EarlyView.
Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo, Mengda Ren, Gavin Wen Zhao Loi, Eka Norfaishanty Saipuljumri, Jonathan Indajang, Kah Leong Lim, Jialiu Zeng   +6 more
wiley   +1 more source

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The biology of replicative senescence

European Journal of Cancer, 1997
Most cells cannot divide indefinitely due to a process termed cellular or replicative senescence. Replicative senescence appears to be a fundamental feature of somatic cells, with the exception of most tumour cells and possibly certain stem cells. How do cells sense the number of divisions they have completed?
openaire   +4 more sources

Hematopoietic cells and replicative senescence

Experimental Gerontology, 2002
Replicative senescence describes the finite cell replicative capacity in response to chronic proliferative stimulation. A key element in this process is the shortening of the telomeres, which to a major extent is caused by the lack of expression of telomerase.
Rita B, Effros, Amiela, Globerson
openaire   +2 more sources

Replicative senescence: a critical review

Mechanisms of Ageing and Development, 2004
Human cells in culture have a limited proliferative capacity. After a period of vigorous proliferation, the rate of cell division declines and a number of changes occur in the cells including increases in size, in secondary lysosomes and residual bodies, nuclear changes and a number of changes in gene expression which provide biomarkers for senescence.
Cristofalo V. J., LORENZINI, ANTONELLO, Allen R. G., Torres C., Tresini M.   +4 more
openaire   +3 more sources

Telomeres and Replicative Senescence

2003
Telomere length measurement can be used both to monitor the proliferation of long-term cultures of somatic cells as well as to determine the replicative history of in vivo-derived cells. The most frequently used technique for telomere length measurement is Southern hybridization (1, 4).
H F, Valenzuela, R B, Effros
openaire   +2 more sources

Replicative Senescence in Human Uroepithelial Cells

1999
Normal human uroepithelial cells (HUCs) proliferate rapidly in culture during early passage and then spontaneously undergo replicative senescence. We previously reported that the cyclin D1-CDK4/6 inhibitor, p16INK4a, is elevated at senescence in HUCs.
J A, Puthenveettil, M S, Burger, C A, Reznikoff   +2 more
openaire   +2 more sources

Conditional and replicative senescence in Escherichia coli

Current Opinion in Microbiology, 2006
Analysis of the molecular mechanisms underlying the cellular degeneration of bacteria in stationary phase (known as conditional senescence) reveals interesting similarities with the aging process of higher organisms. These similarities include the role of self-inflicted oxidative damage and the importance of protein quality control systems in retarding
Asa, Fredriksson, Thomas, Nyström
openaire   +2 more sources