Results 261 to 270 of about 59,366 (303)

Replicative Senescence and Cancer

2006
Replicative senescence appears to be a form of protection against cancer, but the means by which it may have this action are not yet clear. More research is needed to understand the fate of cells with short telomeres in tissues during aging, to understand the effects on neoplasia of telomere shortening in tissues in vivo, to understand whether telomere
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T Cell Replicative Senescence in Human Aging

Current Pharmaceutical Design, 2013
The decline of the immune system appears to be an intractable consequence of aging, leading to increased susceptibility to infections, reduced effectiveness of vaccination and higher incidences of many diseases including osteoporosis and cancer in the elderly.
Jennifer P, Chou, Rita B, Effros
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Telomeres, replicative senescence and human ageing

Maturitas, 2001
Ageing concerns the extracellular environment and cells that are either post-mitotic or capable of division during life. Primary human cells have a finite division capacity in culture before they enter a state of viable cell cycle arrest termed senescence.
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HUVEC replicative senescence

2016
Quantitative and integrated proteome and microRNA analysis of endothelial replicative ...
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A single-stage mechanism controls replicative senescence through Sudden Senescence Syndrome

Biogerontology, 2002
Normal human cells have a finite proliferative potential in vitro. However, some DNA viral proteins, such as SV40 Tg, can alter this and extend the lifespan after which the cells enter crisis, a period when massive cell death occurs. Based on these observations, a two-stage model for cellular senescence has been proposed with a distinct function for ...
Rubelj, Ivica, Huzak, Miljenko, Brdar, Branko, Pereira-Smith, Olivia   +3 more
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Biomarkers of Replicative Senescence Revisited

2016
Biomarkers of replicative senescence can be defined as those ultrastructural and physiological variations as well as molecules whose changes in expression, activity or function correlate with aging, as a result of the gradual exhaustion of replicative potential and a state of permanent cell cycle arrest.
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Stress-induced premature senescence and replicative senescence are different phenotypes, proteomic evidence

Biochemical Pharmacology, 2002
In this paper, we illustrate how a proteomic analysis can be useful to approach complex biological problems, in this case the concept of stress-induced premature senescence (SIPS). According to the stochastic theories of ageing, damage that accumulate with time in the cellular components are responsible for cellular ageing. As a corollary, some sort of
Dierick, J.F., Eliaers, F., Remacle, J., Raes, M., Fey, S.J., Mose Larsen, P., Toussaint, O.   +6 more
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Cellular Aging / Replicative Senescence

1999
Most normal cells do not divide indefinitely. This intrinsic limit to the capacity for cell division is due to a process known as cellular or replicative senescence. Replicative senescence may be a very primitive phenotype, because it has been documented in some very simple single-celled eukaryotes such as Saccharomyces cerevisiae. In higher eukaryotes,
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Replicative senescence and the art of counting

Experimental Gerontology, 2003
The idea that aging is largely the result of (endogenous) stress appears to be at odds with the concept of biological 'clocks', which seem to programme and terminate cellular aging processes. Here, data are reviewed that show that telomeres, the major clock identified in human cells so far, do in fact measure stress and damage accumulation much more ...
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A prospective view on phosphatases and replicative senescence

Experimental Gerontology, 1996
Addition of phosphate to proteins by kinases, or its removal by phosphatases, is probably the control mechanism most often used by cells to maintain homeostasis. This mechanism presents the advantage of being fast, versatile, and easily reversible. It is used by all organisms from bacteria to man.
L, Bernier, E, Wang
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