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Replicative senescence and senescence-like state induced in cancer-derived cells
Mechanisms of Ageing and Development, 2002Studies on the replicative senescence and premature senescence induced by various stresses in normal somatic cells have provided important clues on the role of telomere shortening and mechanisms involved in aging processes and carcinogenesis. Recent work revealed that cancer cells also are induced to undergo replicative senescence state via telomere ...
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Replicative Senescence: the Human Fibroblast Comes of Age
Science, 1990Human diploid fibroblasts undergo replicative senescence predominantly because of arrest at the G 1 /S boundary of the cell cycle. Senescent arrest resembles a process of terminal differentiation that appears to involve repression of proliferation-promoting genes with reciprocal new expression of antiproliferative ...
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4D Genome Rewiring during Oncogene-Induced and Replicative Senescence
Molecular Cell, 2020Satish Sati, Boyan Bonev, Quentin Szabo
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Cellular senescence in ageing: from mechanisms to therapeutic opportunities
Nature Reviews Molecular Cell Biology, 2020Raffaella Di Micco +2 more
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Forging a signature of in vivo senescence
Nature Reviews Cancer, 2015Norman Sharpless, Charles J Sherr
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