Results 81 to 90 of about 136,304 (310)
Emerging roles of telomeric chromatin alterations in cancer [PDF]
, 2019 Telomeres, the nucleoprotein structures that cap the ends of eukaryotic chromosomes, play important and multiple roles in tumorigenesis. Functional telomeres need the establishment of a protective chromatin structure based on the interplay between the ...
Biroccio, Annamaria +2 more
core +1 more source
Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling [PDF]
Nature, 2015 The plant hormone jasmonate plays crucial roles in regulating plant responses to herbivorous insects and microbial pathogens and is an important regulator of plant growth and development. Key mediators of jasmonate signalling include MYC transcription factors, which are repressed by jasmonate ZIM-domain (JAZ) transcriptional repressors in the resting ...
Zhang, Feng +13 more
openaire +2 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Genocidas ir Rezistencija, 1997 This article presents the evolution of the Soviet repressive structures: how many divisions there were and how they changed during the Stalinist period.
Aleksandras Kokurinas
doaj +1 more source
Backlash Against Democracy: The Regulation of Civil Society in Africa [PDF]
, 2010 This paper builds on TrustAfrica funded research regarding the legislative environment for non-governmental organizations. The first section of this paper provides a brief overview of the recent history of state-civil society relations in Africa.
Jeanne Elone
core
The limits of transnational solidarity : the Congress of South African Trade Unions and the Swaziland and Zimbabwean crises [PDF]
, 2013 The Congress of South African Trade Unions (COSATU), the main union federation in South Africa, was instrumental in ending apartheid. This paper evaluates COSATU's post-apartheid role in working for democracy elsewhere in Southern Africa through ...
Dibben, Pauline +2 more
core +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
About one more Organ of the Stalinist Period – Troikas and Petiorkas
Genocidas ir Rezistencija, 2002 Informal formations of party and chekist organs – troykas, chetvyortkas, petyorkas – were formed on the instructions of the Lithuanian Bureau of the Central Committee of the Communist Party of Lithuania (LKP(b)); they began their more active operations ...
Juozas Starkauskas
doaj +1 more source
Repression and activation by multiprotein complexes that alter chromatin structure. [PDF]
Genes & Development, 1996 Recent studies have provided strong evidence that macromolecular complexes are used in the cell to remodel chromatin structure during activation and to create an inaccessible structure during repression, Although there is not yet any rigorous demonstration that modification of chromatin structure plays a direct, causal role in either activation or ...
R E, Kingston +2 more
openaire +2 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source